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Protein Page:
LIMD1 (human)

Overview
LIMD1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. Belongs to the zyxin/ajuba family. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Motility/polarity/chemotaxis
Cellular Component: adherens junction; focal adhesion; cytoplasm; nucleus
Molecular Function: protein binding; zinc ion binding; transcription corepressor activity
Biological Process: cell migration; transcription, DNA-dependent; multicellular organismal development; cytoskeleton organization and biogenesis; signal transduction; miRNA-mediated gene silencing; osteoblast development; regulation of cell shape; regulation of transcription, DNA-dependent; response to hypoxia; negative regulation of osteoblast differentiation; cytoplasmic mRNA processing body assembly; negative regulation of transcription, DNA-dependent; phosphorylation
Reference #:  Q9UGP4 (UniProtKB)
Alt. Names/Synonyms: LIM domain-containing protein 1; LIM domains containing 1; LIMD1
Gene Symbols: LIMD1
Molecular weight: 72,190 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LIMD1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S12-p DDLGLEAsKFIEDLN
0 47 Y21-p FIEDLNMyEAsKDGL
0 9 S24-p DLNMyEAsKDGLFRV
0 1 T69-p QQLLQEEtLPRGSRG
0 4 Y137-p QEQRSRPyLHGTRHG
0 2 S145-p LHGTRHGsQDCGsRE
0 2 S150-p HGsQDCGsRESLATS
0 5 S172-p PGPCEDPsCLtHGDy
0 1 T175-p CEDPsCLtHGDyyDN
0 39 Y179-p sCLtHGDyyDNLsLA
0 13 Y180-p CLtHGDyyDNLsLAs
0 9 S184-p GDyyDNLsLAsPKWG
0 13 S187-p yDNLsLAsPKWGDKP
0 3 S197-p WGDKPGVsPsIGLSV
0 1 S199-p DKPGVsPsIGLSVGs
0 1 S206-p sIGLSVGsGWPssPG
0 3 S210-p SVGsGWPssPGsDPP
0 2 S211-p VGsGWPssPGsDPPL
0 6 S214-p GWPssPGsDPPLPKP
0 8 S233-p PLNHRQLsLSSSRsS
0 1 S239-p LsLSSSRsSEGsLGG
0 4 S243-p SSRsSEGsLGGQNsG
0 1 S249-p GsLGGQNsGIGGRSS
0 1 T260-p GRSSEKPtGLWSTAS
0 1 S268-p GLWSTASsQRVsPGL
0 10 S272-p TASsQRVsPGLPsPN
0 12 S277-p RVsPGLPsPNLENGA
0 5 T294-p VGPVQPRtPsVSAPL
0 2 S296-p PVQPRtPsVSAPLAL
0 3 S304-p VSAPLALsCPRQGGL
0 9 S314-p RQGGLPRsNsGLGGE
0 23 S316-p GGLPRsNsGLGGEVS
0 1 G317 GLPRsNsGLGGEVSG
0 1 S346 DGPKSYLSSSAPSSS
0 1 T379 PGCTDLGTGPKLsPT
0 2 G380 GCTDLGTGPKLsPTs
0 5 S384-p LGTGPKLsPTsLVHP
0 2 S387-p GPKLsPTsLVHPVMS
0 1 P405 ELSCKEGPLGWSSDG
0 2 S413-p LGWSSDGsLGSVLLD
0 9 S421-p LGSVLLDsPssPRVR
0 3 S423-p SVLLDsPssPRVRLP
0 9 S424-p VLLDsPssPRVRLPC
0 14 Y527-p FCEEDFLySGFQQSA
0 4 S667 KRLEKRPSSTALHQH
  mouse

 
S12 DDLGLEASKFIEDLN
Y21 FIEDLNMYEASKDGL
S24 DLNMYEASKDGLFRV
A70 QQLLQEEALPRAGRS
S131 QEQRIRPSAHGARPG
S139 AHGARPGSQNCGSRE
S144 PGSQNCGSREGPVSS
S167 SPSCEDPSCLTHGDY
T170 CEDPSCLTHGDYYDN
Y174 SCLTHGDYYDNFSLA
Y175 CLTHGDYYDNFSLAS
S179 GDYYDNFSLASPQWG
S182 YDNFSLASPQWGDKP
C192 WGDKPEGCPSVSLGV
S194 DKPEGCPSVSLGVGS
S201 SVSLGVGSGWPGCPG
G205 GVGSGWPGCPGNDST
C206 VGSGWPGCPGNDSTL
N209 GWPGCPGNDSTLPKS
S228 HPYQPQLSTVCSGRS
S235 STVCSGRSFESGISG
S238 CSGRSFESGISGQDG
G245 SGISGQDGGIGGHSS
T256 GHSSEKPTGLWSTAS
S264 GLWSTASSQRVNLGF
N268 TASSQRVNLGFSSMG
S273 RVNLGFSSMGLENGT
G286 GTSAQPKGTTVSAPM
T288 SAQPKGTTVSAPMVP
S296 VSAPMVPSSASQGAC
R306 SQGACPKRDsGLGYE
S308-p GACPKRDsGLGYEAS
G309 ACPKRDsGLGYEASG
S338-p DGPKSYLsVSAPLSS
T371-p FGCVESGtsPKPsPT
S372-p GCVESGtsPKPsPTs
S376-p SGtsPKPsPTsNVHP
S379-p sPKPsPTsNVHPVMS
S397-p ELSCKESsPSWSTDS
S405 PSWSTDSSLEPVLPG
S413-p LEPVLPGsPtPSRVR
T415-p PVLPGsPtPSRVRLP
P416 VLPGsPtPSRVRLPC
Y519-p FCEEDFLySGFQQSA
S659-p KRLEKGPsPAPLHQH
  rat

 
S12 DDLGLEASKFIEDLN
Y21 FIEDLNMYEASKDGL
S24 DLNMYEASKDGLFRV
A70 QQLLQEEALPRAGRS
S131 QEQRTRPSAHGARPG
S139 AHGARPGSQNCGSRE
S144 PGSQNCGSREGPVSS
S166 LGPCEDPSCLTHGDY
T169 CEDPSCLTHGDYYDN
Y173 SCLTHGDYYDNFSLA
Y174 CLTHGDYYDNFSLAS
S178 GDYYDNFSLASPQWG
S181 YDNFSLASPQWGDKP
S191 WGDKPEESPSMSLSV
S193 DKPEESPSMSLSVGS
S200 SMSLSVGSGWPGCPG
G204 SVGSGWPGCPGNDSL
C205 VGSGWPGCPGNDSLS
N208 GWPGCPGNDSLSHRS
S227 HPYHPQLSMCSGRSF
S233 LSMCSGRSFESGQDS
S236 CSGRSFESGQDSGIG
S240 SFESGQDSGIGGHSS
T251 GHSSEKPTGLWSTAS
S259 GLWSTASSQRVNLGF
N263 TASSQRVNLGFSSTG
S268 RVNLGFSSTGLENGT
G281 GTPAQPKGTTVSAPM
T283 PAQPKGTTVSAPMVP
S291 VSAPMVPSSTSQGAC
R301 SQGACLRRDssLGYE
S303-p GACLRRDssLGYEAP
S304-p ACLRRDssLGYEAPG
S333 DGPKSYLSVSAPLSS
T366 LGCVESGTSPKPSPT
S367 GCVESGTSPKPSPTS
S371 SGTSPKPSPTSNVHP
S374 SPKPSPTSNVHPVMS
P392 ELSCKESPPSWSTDS
S400 PSWSTDSSLGPVLPE
S408 LGPVLPESPTPSRVR
T410 PVLPESPTPSRVRLP
P411 VLPESPTPSRVRLPC
Y514 FCEEDFLYSGFQQSA
S654 KRLEKGPSPASLHQH
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