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Protein Page:
SMARCC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMARCC1 a core component of the BAF (SWI/SNF) complex. This family of complexes remodels chromatin structures, enabling transcription factors to gain access to DNA. They play important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling is due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain BAF53A and PHF10, are exchanged for homologous alternative BAF53B and BAF45B or BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. Component of 6 multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I), WINAC and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, BAF53A or BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. Component of the BAF (hSWI/SNF) complex, which includes at least actin (ACTB), ARID1A, ARID1B, SMARCA2, SMARCA4, BAF53A, BAF53B, SMARCE1 SMARCC1, SMARCC2, SMARCB1, and one or more of SMARCD1, SMARCD2, or SMARCD3. In muscle cells, the BAF complex also contains DPF3. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the SMARCC family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: XY body; SWI/SNF complex; protein complex; nuclear chromatin; nucleolus; nucleus
Molecular Function: protein binding; nucleosomal DNA binding; transcription coactivator activity; protein N-terminus binding
Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter; nervous system development; organ morphogenesis; transcription, DNA-dependent; nucleosome disassembly; positive regulation of transcription, DNA-dependent; ATP-dependent chromatin remodeling; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q92922 (UniProtKB)
Alt. Names/Synonyms: BAF155; BRG1-associated factor 155; chromatin remodeling complex BAF155 subunit; CRACC1; mammalian chromatin remodeling complex BRG1-associated factor 155; Rsc8; SMARCC1; SMRC1; SRG3; SWI/SNF complex 155 kDa subunit; SWI/SNF complex subunit SMARCC1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI3
Gene Symbols: SMARCC1
Molecular weight: 122,867 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMARCC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 19 Y171-p CLTRPNIyLIPDIDL
0 2 K179-ub LIPDIDLkLANkLKD
0 1 K183-ub IDLkLANkLKDIIKR
0 1 S301 VSFRQRISTKNEEPV
0 26 S310-p KNEEPVRsPERRDRK
0 2 S319-p ERRDRKAsANARKRK
0 57 S328-p NARKRKHsPsPPPPt
0 57 S330-p RKRKHsPsPPPPtPt
0 24 T335-p sPsPPPPtPtESRKK
0 10 T337-p sPPPPtPtESRKKSG
0 2 S339 PPPtPtESRKKSGkk
0 8 K345-ac ESRKKSGkkGQAsLy
0 9 K346-ac SRKKSGkkGQAsLyG
0 4 S350-p SGkkGQAsLyGkRRs
0 14 Y352-p kkGQAsLyGkRRsQk
0 31 K354-ac GQAsLyGkRRsQkEE
0 20 S357-p sLyGkRRsQkEEDEQ
0 2 K359-ac yGkRRsQkEEDEQED
0 1 T375 TKDMEDPTPVPNIEE
0 5 S395-p NVNLKKDsENtPVKG
0 7 T398-p LKKDsENtPVKGGTV
0 1 T404 NtPVKGGTVADLDEQ
0 1 K421-ub ETVTAGGkEDEDPAk
0 1 K428-ub kEDEDPAkGDQSRSV
0 1 S543-p NYQVDPEsRPMAMGP
0 13 T553-p MAMGPPPtPHFNVLA
0 1 S564-p NVLADTPsGLVPLHL
0 8 S573-p LVPLHLRsPQVPAAQ
0 4 K588-ub QMLNFPEkNKEkPVD
0 3 K592-ub FPEkNKEkPVDLQNF
0 1 K608-ac LRTDIYSkKTLAKSK
0 15 K716-ub RVASAAAkAALEEFs
0 1 S723-p kAALEEFsRVREEVP
0 1 S748 VQEAARASGKVDPTY
0 3 A776 EPEKLEGAEEEKMEA
0 7 T801-p ENKVENEtDEGDKAQ
0 1 S816-p DGENEKNsEKEQDsE
0 10 S822-p NsEKEQDsEVsEDTk
0 9 S825-p KEQDsEVsEDTkSEE
0 1 K829-ub sEVsEDTkSEEKETE
0 2 S876-p AAAAALAsAAtkAkH
0 1 T879-p AALAsAAtkAkHLAA
0 16 K880-ub ALAsAAtkAkHLAAV
0 22 K882-ub AsAAtkAkHLAAVEE
0 4 K905-ub LLVETQMkkLEIkLR
0 2 K906-ub LVETQMkkLEIkLRH
0 10 K910-ub QMkkLEIkLRHFEEL
0 1 K925-ub ETIMDREkEALEQQR
0 1 K948-ac NFHMEQLkYAELRAR
0 1 K948-ub NFHMEQLkYAELRAR
0 1 R1064 PGNILGPRVPLTAPN
  mouse

 
Y170-p CLTRPNIyLIPDIDL
K178-ub LIPDIDLkLANKLKD
K182 IDLkLANKLKDIIKR
S300-p VSFRQRIsTKNEEPV
S309-p KNEEPVRsPERRDRK
S318 ERRDRKASANSRKRK
S327-p NSRKRKPsPsPPPPt
S329-p RKRKPsPsPPPPtAt
T334-p sPsPPPPtAtEsRKK
T336-p sPPPPtAtEsRKKSG
S338-p PPPtAtEsRKKSGKK
K344 EsRKKSGKKGQASLY
K345 sRKKSGKKGQASLYG
S349 SGKKGQASLYGkRRs
Y351 KKGQASLYGkRRsQK
K353-ac GQASLYGkRRsQKEE
S356-p SLYGkRRsQKEEDEQ
K358 YGkRRsQKEEDEQED
T374-p TKDMEDPtPVPNIEE
S394 NVNPKKDSENtPVKG
T397-p PKKDSENtPVKGGtV
T403-p NtPVKGGtVADLDEQ
K420 EAVTTGGKEDEDPSK
K427 KEDEDPSKGDPSRSV
S542 NYQVDPESRPMAMGP
T552 MAMGPPPTPHFNVLA
S563 NVLADTPSGLVPLHL
S572-p LVPLHLRsPQVPAAQ
K587-ub QMLNFPEkNKEkPID
K591-ub FPEkNKEkPIDLQNF
K607 LRTDIYSKKTLAKSK
K715-ub RVASAAAkAALEEFS
S722 kAALEEFSRVREEVP
S747-p VQEAARAsGKVDPTY
S775-p EPEKLEGsEEEKMET
S800-p ENKVENEsDEGDKIQ
T815 DRENEKNTEKEQDsD
S821-p NTEKEQDsDVsEDVK
S824-p KEQDsDVsEDVKPEE
K828 sDVsEDVKPEEKENE
S875 AAAAALASAATKAkH
T878 AALASAATKAkHLAA
K879 ALASAATKAkHLAAV
K881-ub ASAATKAkHLAAVEE
K904 LLVETQMKKLEIKLR
K905 LVETQMKKLEIKLRH
K909 QMKKLEIKLRHFEEL
K924 ETIMDREKEALEQQR
K947 NFHMEQLKYAELRAR
K947 NFHMEQLKYAELRAR
R1064-m2 PGNILGPrVPLTAPN
  rat

 
Y170 CLTRPNIYLIPDIDL
K178 LIPDIDLKLANKLKD
K182 IDLKLANKLKDIIKR
S300 VSFRQRISTKNEEPV
S309-p KNEEPVRsPERRERK
S318 ERRERKASANARKRK
S327-p NARKRKHsPsPPPPT
S329-p RKRKHsPsPPPPTAT
T334 sPsPPPPTATEsRKK
T336 sPPPPTATEsRKKSG
S338-p PPPTATEsRKKSGKK
K344 EsRKKSGKKGQASLY
K345 sRKKSGKKGQASLYG
S349 SGKKGQASLYGKRRN
Y351 KKGQASLYGKRRNQK
K353 GQASLYGKRRNQKDE
N356 SLYGKRRNQKDEDEQ
K358 YGKRRNQKDEDEQED
T374 TKDMEDPTPVPNIEE
S394-p NVNPKKDsENtPVKG
T397-p PKKDsENtPVKGGTV
T403 NtPVKGGTVADLDEQ
K420 EAVTTGGKEDEDPSK
K427 KEDEDPSKGDPSRSA
S542 NYQVDPESRPMAMGP
T552 MAMGPPPTPHFNVLA
S563 NVLADTPSGLVPLHL
S572 LVPLHLRSPQVPAAQ
K587 QMLNFPEKNKEKPID
K591 FPEKNKEKPIDLQNF
K607 LRTDIYSKKTLAKSK
K715 RVASAAAKAALEEFS
S722 KAALEEFSRVREEVP
S747 VQEAARASGKVDPTY
S775 EPEKLEGSEEEKMET
S800-p ENKGENEsDEGDKIQ
S815 DGENEKNSEKERDSD
S821 NSEKERDSDTSEDVK
S824 KERDSDTSEDVKPEE
K828 SDTSEDVKPEEKENE
S875 AAAAALASAATKAKH
T878 AALASAATKAKHLAA
K879 ALASAATKAKHLAAV
K881 ASAATKAKHLAAVEE
K904 LLVETQMKKLEIKLR
K905 LVETQMKKLEIKLRH
K909 QMKKLEIKLRHFEEL
K924 ETIMDREKEALEQQR
K947 NFHMEQLKYAELRAR
K947 NFHMEQLKYAELRAR
R1063 PGNILGPRVPLTAPN
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