Home

THEMIS (human)

Overview THEMIS Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Interacts with PLCG1, ITK and GRB2. Belongs to the themis family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell development/differentiation Cellular Component: signalosome; cytoplasm; nucleus Biological Process: positive T cell selection; negative T cell selection; T cell receptor signaling pathway Reference #:  Q8N1K5 (UniProtKB) Alt. Names/Synonyms: bA325O24.3; bA325O24.4; C6orf190; C6orf207; FLJ40584; MGC163388; Protein THEMIS; THEMIS; THMS1; thymocyte selection associated; thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; TSEPA Gene Symbols: THEMIS Molecular weight: 73,452 Da Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below THEMIS

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T93-p	FKIVADKtPyLTMEE
1	0		Y95-p	IVADKtPyLTMEEIT
0	9		K124-u	FYHQKDIkLENLIIK
1	0		Y174-p	LSQEGEFyECEDERI
0	5		K185-u	DERIYTLkEIVEWKI
0	10		K208-u	NLTDFSNkWDSTNPF
0	1		Y220-p	NPFPKDFyGtLILkP
0	1		T222-p	FPKDFyGtLILkPVY
0	2		K226-u	FyGtLILkPVYEIQG
0	1		K312-a	KTIVIHKkYQASRIL
0	1		S321-p	QASRILAsEIRSNFP
1	0		Y353-p	PREFPTAyDLEIAKS
0	1		K362-a	LEIAKSEkEPLHVVA
0	1		T370-p	EPLHVVAtKAFHSPH
1	0		Y429-p	EAALLPLyMEGGFVE
1	0		Y540-p	EEITEEQyyMMRRYE
1	0		Y541-p	EITEEQyyMMRRYES
0	33		S584-p	RTVDLPKsPKRHHVD
0	4		S611-p	DSKVLIGsQNDLVDE

	mouse
T94	FKVMADKTPYLSIEE
Y96	VMADKTPYLSIEEIT
K125	FYHLKDIKLENLIIK
Y175	LSQEGEFYECEDEHI
K186	DEHIYTLKEIVEWKI
K209	KLTDFSNKWDSTNPF
Y221	NPFPEDFYGTLILKP
T223	FPEDFYGTLILKPVY
K227	FYGTLILKPVYEIQG
K313	KTIVIHKKYQASRIL
S322	QASRILASEIRSNFP
Y354	PREFPTAYDLQIAKS
K363-a	LQIAKSRkETLHVVA
T371	ETLHVVATKAFHTLH
Y429	EDAQLPLYMEGGFVE
Y542-p	EEITEEQyyMMRRYE
Y543-p	EITEEQyyMMRRYES
S586	RTINLPKSLKSHHVD
F613	DSRAPVGFQNDVADV

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.