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Protein Page:
THEMIS (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
THEMIS Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Interacts with PLCG1, ITK and GRB2. Belongs to the themis family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Cellular Component: signalosome; cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: positive T cell selection; negative T cell selection; T cell receptor signaling pathway
Reference #:  Q8N1K5 (UniProtKB)
Alt. Names/Synonyms: bA325O24.3; bA325O24.4; C6orf190; C6orf207; FLJ40584; MGC163388; Protein THEMIS; THEMIS; THMS1; thymocyte selection associated; thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; TSEPA
Gene Symbols: THEMIS
Molecular weight: 73,452 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

THEMIS

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y95-p IVADKTPyLTMEEIT
0 9 K124-ub FYHQKDIkLENLIIK
0 2 S168-p HSFNLPLsQEGEFyE
1 0 Y174-p LsQEGEFyECEDERI
0 5 K185-ub DERIYTLkEIVEWKI
0 10 K208-ub NLTDFSNkWDSTNPF
0 1 Y220-p NPFPKDFyGtLILkP
0 1 T222-p FPKDFyGtLILkPVY
0 2 K226-ub FyGtLILkPVYEIQG
0 1 K312-ac KTIVIHKkYQASRIL
0 1 S321-p QASRILAsEIRSNFP
1 0 Y353-p PREFPTAyDLEIAKS
0 1 K362 LEIAKSEKEPLHVVA
0 1 T370-p EPLHVVAtKAFHSPH
1 0 Y429-p EAALLPLyMEGGFVE
1 0 Y540-p EEITEEQyyMMRRYE
1 0 Y541-p EITEEQyyMMRRYES
0 33 S584-p RTVDLPKsPKRHHVD
0 6 S611-p DSKVLIGsQNDLVDE
  mouse

 
Y96 VMADKTPYLSIEEIT
K125 FYHLKDIKLENLIIK
S169 HSFTLPLSQEGEFYE
Y175 LSQEGEFYECEDEHI
K186 DEHIYTLKEIVEWKI
K209 KLTDFSNKWDSTNPF
Y221 NPFPEDFYGTLILKP
T223 FPEDFYGTLILKPVY
K227 FYGTLILKPVYEIQG
K313 KTIVIHKKYQASRIL
S322 QASRILASEIRSNFP
Y354 PREFPTAYDLQIAKS
K363-ac LQIAKSRkETLHVVA
T371 ETLHVVATKAFHTLH
Y429 EDAQLPLYMEGGFVE
Y542-p EEITEEQyyMMRRYE
Y543-p EITEEQyyMMRRYES
S586 RTINLPKSLKSHHVD
F613 DSRAPVGFQNDVADV
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