Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Guanine nucleotide exchange factor, Rac/Rho
Biological Process: lamellipodium biogenesis; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; apoptosis; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; JNK cascade; positive regulation of GTPase activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.