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RCAS1 (human)

Overview RCAS1 May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases. Homodimer. By estrogen. Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Membrane protein, integral Cellular Component: Golgi membrane; Golgi apparatus; focal adhesion; plasma membrane; integral to membrane Molecular Function: apoptotic protease activator activity Biological Process: apoptosis; regulation of cell growth Reference #:  O00559 (UniProtKB) Alt. Names/Synonyms: cancer associated surface antigen; Cancer-associated surface antigen RCAS1; EB9; EBAG9; estrogen receptor binding site associated, antigen, 9; Estrogen receptor-binding fragment-associated gene 9 protein; PDAF; RCAS1; Receptor-binding cancer antigen expressed on SiSo cells Gene Symbols: EBAG9 Molecular weight: 24,377 Da Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RCAS1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	133		S36-p	SGRGRKLsGDQItLP
0	7		T41-p	KLsGDQItLPTTVDy
0	44		Y48-p	tLPTTVDyssVPKQT
0	20		S49-p	LPTTVDyssVPKQTD
0	7		S50-p	PTTVDyssVPKQTDV
0	100		Y94-p	LEQLEPDyFKDMtPt
0	3		T99-p	PDyFKDMtPtIRKTQ
0	10		T101-p	yFKDMtPtIRKTQKI
0	1		K202-a	KEAQRLMkKEQNKIG

	mouse
S36-p	SGRGRKLsGDQItLP
T41-p	KLsGDQItLPTTVDY
Y48	tLPTTVDYSSVPKQT
S49	LPTTVDYSSVPKQTD
S50	PTTVDYSSVPKQTDV
Y94	LEQLEPDYFKDMTPT
T99	PDYFKDMTPTIRKTQ
T101	YFKDMTPTIRKTQKI
K202	KEAQRLMKKEQNKIG

	rat
S36-p	SGRGRKLsGDQITLP
T41	KLsGDQITLPTTVDY
Y48	TLPTTVDYSSVPKQT
S49	LPTTVDYSSVPKQTD
S50	PTTVDYSSVPKQTDV
Y94	LEQLEPDYFKDMTPT
T99	PDYFKDMTPTIRKTQ
T101	YFKDMTPTIRKTQKI
K202	KEAQRLLKKEQNKMG

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