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afadin (human)

Overview afadin plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cell adhesion Cellular Component: cell-cell adherens junction; apical part of cell; cytoplasm; nucleolus; plasma membrane; intercellular junction; cell junction; nucleus; cytosol Molecular Function: protein C-terminus binding; cell adhesion molecule binding Biological Process: intercellular junction assembly and maintenance; cell-cell signaling; cell adhesion; signal transduction Reference #:  P55196 (UniProtKB) Alt. Names/Synonyms: AF-6; AF6; AFAD; Afadin; ALL1-fused gene from chromosome 6 protein; FLJ34371; MLLT4; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia, translocated to, 4; Protein AF-6; RP3-431P23.3; translocated to, 4 Gene Symbols: MLLT4 Molecular weight: 206,804 Da Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below afadin 1T2M - A=987-1077 (human) 1XZ9 - A=985-1079 (human) 2AIN - A=987-1077 (human) 2EXG - A=985-1079 (human) 1WLN - A=381-487 (mouse) 1WXA - A=246-348 (mouse) 3AXA - A/B=1003-1095 (mouse)

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	Sites Implicated In
molecular association, regulation: T909‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K90	MRMLSSPKYSLyEVH
0	1		Y91	RMLSSPKYSLyEVHV
0	117		Y94-p	SSPKYSLyEVHVSGE
0	1		T160-p	VIQNFKRtLsKKEKK
0	1		S162-p	QNFKRtLsKKEKKEK
0	17		Y203-p	SRLAAEVyKDMPETS
0	1		T214	PETSFTRTIsNPEVV
0	44		S216-p	TSFTRTIsNPEVVMK
0	3		S246-p	SSDGRPDsGGtLRIy
0	4		T249-p	GRPDsGGtLRIyADS
0	3		Y253-p	sGGtLRIyADSLKPN
0	1		K258	RIyADSLKPNIPyKT
0	23		Y263-p	SLKPNIPyKTILLST
0	1		Y295-p	EKENPKDyCIARVML
0	1		K315	HSDEKGAKEIILDDD
0	1		K336	FREWPSDKGILVFQL
0	1		T363-p	KKHLEGKtPKGKERA
0	2		S373	GKERADGSGyGSTLP
0	5		Y375-p	ERADGSGyGSTLPPE
0	1		K383	GSTLPPEKLPYLVEL
0	4		S391	LPYLVELSPGRRNHF
0	1		Y401	RRNHFAYYNYHTYED
0	3		S424-p	KLYRLQLsVTEVGTE
0	2		S512-p	DHALAKRsVDGGLMV
0	1		T552	ALPTSKSTTRLDsDR
0	3		S557-p	KSTTRLDsDRVssAs
0	4		S561-p	RLDsDRVssAsstAE
0	6		S562-p	LDsDRVssAsstAER
0	2		S564-p	sDRVssAsstAERGM
0	3		S565-p	DRVssAsstAERGMV
0	5		T566-p	RVssAsstAERGMVK
0	34		Y584-p	RVEQQPDyRRQESRT
0	1		S589	PDyRRQESRTQDASG
0	3		S655	NQYRPDISPTERTHK
0	1		S672-p	AVVNKMVsMMEGVIQ
1	0		T909-p	VVTVAENtADELARS
0	2		Y980-p	SPGTWTIyFEGADyE
0	15		Y986-p	IyFEGADyESHLLRE
0	1		K1013	EIITVTLKKQNGMGL
0	1		K1026	GLSIVAAKGAGQDKL
0	1		K1032	AKGAGQDKLGIYVKS
0	1		K1042	IYVKSVVKGGAADVD
0	4		T1081-p	AAELMTRtSsVVTLE
0	34		S1083-p	ELMTRtSsVVTLEVA
0	47		S1107-p	ATLLNQPsPMMQRIS
0	19		S1126-p	SGKPRPKsEGFELyN
0	6		Y1132-p	KsEGFELyNNStQNG
0	1		S1135	GFELyNNStQNGsPE
0	1		T1136-p	FELyNNStQNGsPEs
0	3		S1140-p	NNStQNGsPEsPQLP
0	3		S1143-p	tQNGsPEsPQLPWAE
0	2		Y1151-p	PQLPWAEySEPKKLP
0	29		S1172-p	KNRADHRssPNVANQ
0	22		S1173-p	NRADHRssPNVANQP
0	70		S1182-p	NVANQPPsPGGKsAy
0	2		S1187-p	PPsPGGKsAyASGTt
0	4		Y1189-p	sPGGKsAyASGTtAK
0	1		T1194-p	sAyASGTtAKITSVs
0	7		S1201-p	tAKITSVstGNLCtE
0	2		T1202-p	AKITSVstGNLCtEE
0	3		T1207-p	VstGNLCtEEQtPPP
0	10		T1211-p	NLCtEEQtPPPRPEA
0	3		Y1219-p	PPPRPEAyPIPTQTy
0	4		Y1226-p	yPIPTQTyTREyFtF
0	67		Y1230-p	TQTyTREyFtFPAsK
0	32		T1232-p	TyTREyFtFPAsKsQ
0	1		S1236-p	EyFtFPAsKsQDRMA
0	1		K1237	yFtFPAsKsQDRMAP
0	1		S1238-p	FtFPAsKsQDRMAPP
0	1		Y1252-p	PQNQWPNyEEKPHMH
0	1		T1260	EEKPHMHTDSNHSSI
0	11		S1275-p	AIQRVTRsQEELRED
0	34		Y1285-p	ELREDKAyQLERHRI
0	1		S1300-p	EAAMDRKsDSDMWIN
0	1		S1328	HLNHSSKSVtPAStL
0	4		T1330-p	NHSSKSVtPAStLTK
0	2		T1334-p	KSVtPAStLTKSGPG
0	1		T1336	VtPAStLTKSGPGRW
0	1		K1337	tPAStLTKSGPGRWK
1	1		T1352-p	TPAAIPAtPVAVSQP
0	2		Y1419-p	REEHQRWyEKEKARL
0	9		S1455-p	SLNPAPFsPLTAQQM
0	3		T1489-p	QPQQQPRtIERRDLQ
0	146		Y1497-p	IERRDLQyItVsKEE
0	3		T1499-p	RRDLQyItVsKEELS
0	5		S1501-p	DLQyItVsKEELSSG
0	6		S1512-p	LSSGDSLsPDPWKRD
0	81		Y1656-p	KRRQEEGyysRLEAE
0	125		Y1657-p	RRQEEGyysRLEAER
0	3		S1658-p	RQEEGyysRLEAERR
0	8		Y1692-p	RPPLPRDyEPPsPsP
0	2		S1696-p	PRDyEPPsPsPAPGA
0	1		S1698-p	DyEPPsPsPAPGAPP
0	1		K1716	QRNASYLKTQVLsPD
0	13		S1721-p	YLKTQVLsPDSLFTA
0	1		S1753	GPNSYPGSTGAAVGA
0	1		H1761	TGAAVGAHDACRDAK
0	5		S1774-p	AKEKRSKsQDADsPG
0	8		S1779-p	SKsQDADsPGssGAP
0	3		S1782-p	QDADsPGssGAPENL
0	2		S1783-p	DADsPGssGAPENLT
0	253		S1799-p	KERQRLFsQGQDVSN
0	43		T1815-p	VKASRKLtELENELN
0	1		K1824	LENELNTK_______

	afadin iso2
K90	MRMLSSPKYSLYEVH
Y91	RMLSSPKYSLYEVHV
Y94	SSPKYSLYEVHVSGE
T159	VIQNFKRTLSKKEKK
S161	QNFKRTLSKKEKKEK
Y202	SRLAAEVYKDMPETS
T213	PETSFTRTISNPEVV
S215	TSFTRTISNPEVVMK
S245	SSDGRPDSGGTLRIY
T248	GRPDSGGTLRIYADS
Y252	SGGTLRIYADSLKPN
K257	RIYADSLKPNIPYKT
Y262	SLKPNIPYKTILLST
Y294	EKENPKDYCIARVML
K314	HSDEKGAKEIILDDD
K335	FREWPSDKGILVFQL
T362	KKHLEGKTPKGKERA
S372	GKERADGSGYGSTLP
Y374	ERADGSGYGSTLPPE
K382	GSTLPPEKLPYLVEL
S390	LPYLVELSPDGSDSR
-	gap
S408	KLYRLQLSVTEVGTE
S496	DHALAKRSVDGGLMV
T536	ALPTSKSTTRLDSDR
S541	KSTTRLDSDRVSSAS
S545	RLDSDRVSSASSTAE
S546	LDSDRVSSASSTAER
S548	SDRVSSASSTAERGM
S549	DRVSSASSTAERGMV
T550	RVSSASSTAERGMVK
Y568	RVEQQPDYRRQESRT
S573	PDYRRQESRTQDASG
S639	NQYRPDISPTERTHK
S656	AVVNKMVSMMEGVIQ
T893	VVTVAENTADELARS
Y964	SPGTWTIYFEGADYE
Y970	IYFEGADYESHLLRE
K997	EIITVTLKKQNGMGL
K1010	GLSIVAAKGAGQDKL
K1016	AKGAGQDKLGIYVKS
K1026	IYVKSVVKGGAADVD
T1065	AAELMTRTSSVVTLE
S1067	ELMTRTSSVVTLEVA
S1091	ATLLNQPSPMMQRIS
S1110	SGKPRPKSEGFELYN
Y1116	KSEGFELYNNSTQNG
S1119	GFELYNNSTQNGSPE
T1120	FELYNNSTQNGSPES
S1124	NNSTQNGSPESPQLP
S1127	TQNGSPESPQLPWAE
Y1135	PQLPWAEYSEPKKLP
S1156	KNRADHRSSPNVANQ
S1157	NRADHRSSPNVANQP
S1166	NVANQPPSPGGKSAY
S1171	PPSPGGKSAYASGTT
Y1173	SPGGKSAYASGTTAK
T1178	SAYASGTTAKITSVS
S1185	TAKITSVSTGNLCTE
T1186	AKITSVSTGNLCTEE
T1191	VSTGNLCTEEQTPPP
T1195	NLCTEEQTPPPRPEA
Y1203	PPPRPEAYPIPTQTY
Y1210	YPIPTQTYTREYFTF
Y1214	TQTYTREYFTFPASK
T1216	TYTREYFTFPASKSQ
S1220	EYFTFPASKSQDRMA
K1221	YFTFPASKSQDRMAP
S1222	FTFPASKSQDRMAPP
Y1236	PQNQWPNYEEKPHMH
T1244	EEKPHMHTDSNHSSI
S1259	AIQRVTRSQEELRED
Y1269	ELREDKAYQLERHRI
S1284	EAAMDRKSDSDMWIN
S1312	HLNHSSKSVTPASTL
T1314	NHSSKSVTPASTLTK
T1318	KSVTPASTLTKSGPG
T1320	VTPASTLTKSGPGRW
K1321	TPASTLTKSGPGRWK
T1336	TPAAIPATPVAVSQP
Y1403	REEHQRWYEKEKARL
S1439	SLNPAPFSPLTAQQM
T1473	QPQQQPRTIERRDLQ
Y1481	IERRDLQYITVSKEE
T1483	RRDLQYITVSKEELS
S1485	DLQYITVSKEELSSG
S1496	LSSGDSLSPDPWKRD
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	afadin iso3
K90	MRMLSSPKYSLyEVH
Y91	RMLSSPKYSLyEVHV
Y94-p	SSPKYSLyEVHVSGE
T159	VIQNFKRTLSKKEKK
S161	QNFKRTLSKKEKKEK
Y202	SRLAAEVYKDMPETS
T213	PETSFTRTISNPEVV
S215	TSFTRTISNPEVVMK
S245	SSDGRPDSGGTLRIY
T248	GRPDSGGTLRIYADS
Y252	SGGTLRIYADSLKPN
K257	RIYADSLKPNIPyKT
Y262-p	SLKPNIPyKTILLST
Y294	EKENPKDYCIARVML
K314	HSDEKGAKEIILDDD
K335	FREWPSDKGILVFQL
T362	KKHLEGKTPKGKERA
S372-p	GKERADGsGyGSTLP
Y374-p	ERADGsGyGSTLPPE
K382	GSTLPPEKLPYLVEL
S390	LPYLVELSPDGSDSR
-	gap
S408	KLYRLQLSVTEVGTE
S496	DHALAKRSVDGGLMV
T536	ALPTSKSTTRLDSDR
S541	KSTTRLDSDRVSSAS
S545	RLDSDRVSSASSTAE
S546	LDSDRVSSASSTAER
S548	SDRVSSASSTAERGM
S549	DRVSSASSTAERGMV
T550	RVSSASSTAERGMVK
Y568	RVEQQPDYRRQESRT
S573	PDYRRQESRTQDASG
S639	NQYRPDISPTERTHK
S656	AVVNKMVSMMEGVIQ
T893	VVTVAENTADELARS
Y964	SPGTWTIYFEGADyE
Y970-p	IYFEGADyESHLLRE
K997	EIITVTLKKQNGMGL
K1010	GLSIVAAKGAGQDKL
K1016	AKGAGQDKLGIYVKS
K1026	IYVKSVVKGGAADDG
T1064	AAELMTRTSSVVTLE
S1066	ELMTRTSSVVTLEVA
S1090-p	ATLLNQPsPMMQRIS
S1109-p	SGKPRPKsEGFELYN
Y1115	KsEGFELYNNSTQNG
S1118	GFELYNNSTQNGSPE
T1119	FELYNNSTQNGSPES
S1123	NNSTQNGSPESPQLP
S1126	TQNGSPESPQLPWAE
Y1134	PQLPWAEYSEPKKLP
S1155	KNRADHRSSPNVANQ
S1156	NRADHRSSPNVANQP
S1165	NVANQPPSPGGKSAY
S1170	PPSPGGKSAYASGTT
Y1172	SPGGKSAYASGTTAK
T1177	SAYASGTTAKITSVS
S1184	TAKITSVSTGNLCTE
T1185	AKITSVSTGNLCTEE
T1190	VSTGNLCTEEQTPPP
T1194	NLCTEEQTPPPRPEA
Y1202	PPPRPEAYPIPTQTY
Y1209	YPIPTQTYTREyFTF
Y1213-p	TQTYTREyFTFPASK
T1215	TYTREyFTFPASKSQ
S1219	EyFTFPASKSQDRMA
K1220	yFTFPASKSQDRMAP
S1221	FTFPASKSQDRMAPP
Y1235	PQNQWPNYEEKPHMH
T1243	EEKPHMHTDSNHSSI
S1258	AIQRVTRSQEELRED
Y1268-p	ELREDKAyQLERHRI
S1283	EAAMDRKSDSDMWIN
S1311	HLNHSSKSVTPASTL
T1313	NHSSKSVTPASTLTK
T1317	KSVTPASTLTKSGPG
T1319	VTPASTLTKSGPGRW
K1320	TPASTLTKSGPGRWK
T1335	TPAAIPATPVAVSQP
Y1402	REEHQRWYEKEKARL
S1438	SLNPAPFSPLTAQQM
T1472	QPQQQPRTIERRDLQ
Y1480-p	IERRDLQyITVSKEE
T1482	RRDLQyITVSKEELS
S1484	DLQyITVSKEELSSG
S1495	LSSGDSLSPDPWKRD
Y1639-p	KRRQEEGyYSRLEAE
Y1640	RRQEEGyYSRLEAER
S1641	RQEEGyYSRLEAERR
-	gap
-	gap
-	gap
-	gap
-	gap
S1672-p	GPNSYPGsTGAAVGA
H1680	TGAAVGAHDACRDAK
S1693	AKEKRSKSQDADsPG
S1698-p	SKSQDADsPGssGAP
S1701-p	QDADsPGssGAPENL
S1702-p	DADsPGssGAPENLT
S1718-p	KERQRLFsQGQDVSN
T1734-p	VKASRKLtELENELN
K1743	LENELNTK_______

	mouse ► Hide Isoforms
K90-u	MRMLSSPkySLyEVH
Y91-p	RMLSSPkySLyEVHV
Y94-p	SSPkySLyEVHVSGE
T160	VIQNFKRTLSKKEKK
S162	QNFKRTLSKKEKKEK
Y203-p	SRLAAEVyKDMPETS
T214-p	PETSFTRtIsNPEVV
S216-p	TSFTRtIsNPEVVMK
S246-p	SSDGRPDsGGtLRIy
T249-p	GRPDsGGtLRIyADS
Y253-p	sGGtLRIyADSLkPN
K258-u	RIyADSLkPNIPYKT
Y263	SLkPNIPYKTILLST
Y295	EKENPKDYCIARVML
K315-u	HSDERGAkEIILDDD
K336-u	FREWPSDkGILVFQL
S363-p	KKHVEGKsLKGKDRA
S373	GKDRADGSGYGSALP
Y375	DRADGSGYGSALPPE
K383	GSALPPEKLPYLVEL
S391-p	LPYLVELsPGRRNHF
Y401-p	RRNHFAYySYHTYED
S424-p	KLYRLQLsVTEVGTE
S512-p	DHVLSKRsVDGGLMV
T552-p	ALPASRStTRLDsDR
S557-p	RStTRLDsDRVssAs
S561-p	RLDsDRVssAsstAE
S562-p	LDsDRVssAsstAER
S564-p	sDRVssAsstAERGM
S565-p	DRVssAsstAERGMV
T566-p	RVssAsstAERGMVK
Y584-p	RLDQEQEyRRRENRT
N589	QEyRRRENRTQDATG
S655-p	SQHRPDIsPTERTHK
S672	AVVNKMVSMMEGVIQ
T909	VVAVAENTADELARS
Y980	SPGTWTIYFEGADYE
Y986	IYFEGADYESHLMRE
K1013-u	EIITVTLkKQNGMGL
K1026-a	GLSIVAAkGAGQDkL
K1032-a	AkGAGQDkLGIYVKS
K1042-u	IYVKSVVkGGAADVD
T1081-p	AAELMTRtSsVVTLE
S1083-p	ELMTRtSsVVTLEVA
S1107-p	ATLLNQPsPMMQRIS
S1126-p	SGKPRPKsEGFELyN
Y1132-p	KsEGFELyNNsAQNG
S1135-p	GFELyNNsAQNGsPE
A1136	FELyNNsAQNGsPEs
S1140-p	NNsAQNGsPEsPQMP
S1143-p	AQNGsPEsPQMPWTE
Y1151	PQMPWTEYSEPKKLP
S1172-p	KNRADHRssPNVANQ
S1173-p	NRADHRssPNVANQP
S1182-p	NVANQPPsPGGKGPy
G1187	PPsPGGKGPyTSGTA
Y1189-p	sPGGKGPyTSGTAAK
A1194	GPyTSGTAAKITSVs
S1201-p	AAKITSVstGNLCtE
T1202-p	AKITSVstGNLCtEE
T1207-p	VstGNLCtEEQsPPP
S1211-p	NLCtEEQsPPPRPEA
Y1219-p	PPPRPEAyPIPTQTY
Y1226	yPIPTQTYTREyFtF
Y1230-p	TQTYTREyFtFPAsk
T1232-p	TYTREyFtFPAsksQ
S1236-p	EyFtFPAsksQDRMA
K1237-u	yFtFPAsksQDRMAP
S1238-p	FtFPAsksQDRMAPP
Y1252	PQSQWPNYEEKPHVH
T1260-p	EEKPHVHtESNHSSI
S1275-p	AIQRVTRsQEELREE
Y1285-p	ELREEKVyQLERHRV
C1300	EAGMDRKCDSDMWIN
S1328-p	HLNHSSKsVtPAStL
T1330-p	NHSSKsVtPAStLtk
T1334-p	KsVtPAStLtkSGPG
T1336-p	VtPAStLtkSGPGRW
K1337-u	tPAStLtkSGPGRWK
T1352	TPAAVLPTPVAVSQP
Y1418	REEHQRWYEKEKARL
S1454	TLNPASFSPLATQAK
T1487	QPQQQPRTIERKDLQ
Y1495-p	IERKDLQyItIsKEE
T1497-p	RKDLQyItIsKEELS
S1499-p	DLQyItIsKEELSSG
S1510-p	LSSGDSLsPDPWKRD
Y1654-p	KRRQEEGyYSRLEAE
Y1655	RRQEEGyYSRLEAER
S1656	RQEEGyYSRLEAERR
Y1690	RPPLPRDYEPPSLSS
S1694	PRDYEPPSLSSAPCA
S1696	DYEPPSLSSAPCAPP
K1714-u	QRNASYLkTQVLsPD
S1719-p	YLkTQVLsPDSLFTA
S1749	GPNSYSGSAGTAVGA
Y1757-p	AGTAVGAyDAPREAR
S1770-p	AREKLTRsQDADLPG
L1775	TRsQDADLPGSSGAP
S1778	QDADLPGSSGAPENL
S1779	DADLPGSSGAPENLT
S1795-p	KERQRLFsQGQDVSD
T1811-p	VKASRKLtELENELN
K1820-a	LENELNTk_______

	afadin iso2
K90	MRMLSSPKYSLYEVH
Y91	RMLSSPKYSLYEVHV
Y94	SSPKYSLYEVHVSGE
T160	VIQNFKRTLSKKEKK
S162	QNFKRTLSKKEKKEK
Y203	SRLAAEVYKDMPETS
T214	PETSFTRTISNPEVV
S216	TSFTRTISNPEVVMK
S246	SSDGRPDSGGTLRIY
T249	GRPDSGGTLRIYADS
Y253	SGGTLRIYADSLKPN
K258	RIYADSLKPNIPYKT
Y263	SLKPNIPYKTILLST
Y295	EKENPKDYCIARVML
K315	HSDERGAKEIILDDD
K336	FREWPSDKGILVFQL
S363	KKHVEGKSLKGKDRA
S373	GKDRADGSGYGSALP
Y375	DRADGSGYGSALPPE
K383-u	GSALPPEkLPYLVEL
S391	LPYLVELSPDGSDSR
-	gap
S409	KLYRLQLSVTEVGTE
S497	DHVLSKRSVDGGLMV
T537	ALPASRSTTRLDSDR
S542	RSTTRLDSDRVSSAS
S546	RLDSDRVSSASSTAE
S547	LDSDRVSSASSTAER
S549	SDRVSSASSTAERGM
S550	DRVSSASSTAERGMV
T551	RVSSASSTAERGMVK
Y569	RLDQEQEYRRRENRT
N574	QEYRRRENRTQDATG
S640	SQHRPDISPTERTHK
S657	AVVNKMVSMMEGVIQ
T894	VVAVAENTADELARS
Y965	SPGTWTIYFEGADYE
Y971	IYFEGADYESHLMRE
K998	EIITVTLKKQNGMGL
K1011	GLSIVAAKGAGQDKL
K1017	AKGAGQDKLGIYVKS
K1027	IYVKSVVKGGAADVD
T1066	AAELMTRTSSVVTLE
S1068	ELMTRTSSVVTLEVA
S1092	ATLLNQPSPMMQRIS
S1111	SGKPRPKSEGFELYN
Y1117	KSEGFELYNNSAQNG
S1120	GFELYNNSAQNGSPE
A1121	FELYNNSAQNGSPES
S1125	NNSAQNGSPESPQMP
S1128	AQNGSPESPQMPWTE
Y1136	PQMPWTEYSEPKKLP
S1157	KNRADHRSSPNVANQ
S1158	NRADHRSSPNVANQP
S1167	NVANQPPSPGGKGPY
G1172	PPSPGGKGPYTSGTA
Y1174	SPGGKGPYTSGTAAK
A1179	GPYTSGTAAKITSVS
S1186	AAKITSVSTGNLCTE
T1187	AKITSVSTGNLCTEE
T1192	VSTGNLCTEEQSPPP
S1196	NLCTEEQSPPPRPEA
Y1204	PPPRPEAYPIPTQTY
Y1211	YPIPTQTYTREYFTF
Y1215	TQTYTREYFTFPASK
T1217	TYTREYFTFPASKSQ
S1221	EYFTFPASKSQDRMA
K1222	YFTFPASKSQDRMAP
S1223	FTFPASKSQDRMAPP
Y1237	PQSQWPNYEEKPHVH
T1245	EEKPHVHTESNHSSI
S1260	AIQRVTRSQEELREE
Y1270	ELREEKVYQLERHRV
C1285	EAGMDRKCDSDMWIN
S1313	HLNHSSKSVTPASTL
T1315	NHSSKSVTPASTLTK
T1319	KSVTPASTLTKSGPG
T1321	VTPASTLTKSGPGRW
K1322	TPASTLTKSGPGRWK
T1337	TPAAVLPTPVAVSQP
Y1403	REEHQRWYEKEKARL
S1439	TLNPASFSPLATQAK
T1472	QPQQQPRTIERKDLQ
Y1480	IERKDLQYITISKEE
T1482	RKDLQYITISKEELS
S1484	DLQYITISKEELSSG
S1495	LSSGDSLSPDPWKRD
Y1639	KRRQEEGYYSRLEAE
Y1640	RRQEEGYYSRLEAER
S1641	RQEEGYYSRLEAERR
Y1675	RPPLPRDYEPPSLSS
S1679	PRDYEPPSLSSAPCA
S1681	DYEPPSLSSAPCAPP
K1699	QRNASYLKTQVLSPD
S1704	YLKTQVLSPDSLFTA
S1734	GPNSYSGSAGTAVGA
Y1742	AGTAVGAYDAPREAR
S1755	AREKLTRSQDADLPG
L1760	TRSQDADLPGSSGAP
S1763	QDADLPGSSGAPENL
S1764	DADLPGSSGAPENLT
S1780	KERQRLFSQGQDVSD
T1796	VKASRKLTELENELN
K1805	LENELNTK_______

	rat
K90	MRMLSSPKYSLYEVH
Y91	RMLSSPKYSLYEVHV
Y94	SSPKYSLYEVHVSGE
T160	VIQNFKRTLSKKEKK
S162	QNFKRTLSKKEKKEK
Y203	SRLAAEVYKDMPETS
T214	PETSFTRTISNPEVV
S216	TSFTRTISNPEVVMK
S246	SSDGRPDSGGTLRIY
T249	GRPDSGGTLRIYADS
Y253	SGGTLRIYADSLKPN
K258	RIYADSLKPNIPYKT
Y263	SLKPNIPYKTILLST
Y295	EKENPKDYCIARVML
K315	HSDERGAKEIILDDD
K336	FREWPSDKGILVFQL
P363	KKHVEGKPLKGKDRA
S373	GKDRADGSGYGSALP
Y375	DRADGSGYGSALPPE
K383	GSALPPEKLPYLVEL
S391	LPYLVELSPGRRNHF
Y401	RRNHFAYYSYHTYED
S424	KLYRLQLSVTEVGTE
S512	DHVLSKRSVDGGLMV
T552	ALPASRSTTRLDsDR
S557-p	RSTTRLDsDRVSSAS
S561	RLDsDRVSSASSTAE
S562	LDsDRVSSASSTAER
S564	sDRVSSASSTAERGM
S565	DRVSSASSTAERGMV
T566	RVSSASSTAERGMVK
Y584	RLDQEQDYRRREsRT
S589-p	QDYRRREsRTQDAAG
S655	SQHRPDISPTERTHK
S672	AVVNKMVSMMEGVIQ
T916	VVAVAENTADELARS
Y987	SPGTWTIYFEGADYE
Y993	IYFEGADYESHLMRE
K1020	EVITVTLKKQNGMGL
K1033	GLSIVAAKGAGQDKL
K1039	AKGAGQDKLGIYVKS
K1049	IYVKSVVKGGAADVD
T1088	AAELMTRTSsVVTLE
S1090-p	ELMTRTSsVVTLEVA
S1114	ATLLNQPSPMMQRIS
S1133	SGKPRPKSEGFELYN
Y1139	KSEGFELYNNSAQNG
S1142	GFELYNNSAQNGSPE
A1143	FELYNNSAQNGSPES
S1147	NNSAQNGSPESPQMP
S1150	AQNGSPESPQMPWTE
Y1158	PQMPWTEYSEPKKLP
S1179-p	KNRADHRssPNVANQ
S1180-p	NRADHRssPNVANQP
S1189-p	NVANQPPsPGGKSPY
S1194	PPsPGGKSPYTSGTA
Y1196	sPGGKSPYTSGTAAK
A1201	SPYTSGTAAKITSVS
S1208	AAKITSVSTGNLCTE
T1209	AKITSVSTGNLCTEE
T1214	VSTGNLCTEEQTPPP
T1218	NLCTEEQTPPPRPEA
Y1226	PPPRPEAYPIPTQTY
Y1233	YPIPTQTYTREYFTF
Y1237	TQTYTREYFTFPASK
T1239	TYTREYFTFPASKSQ
S1243	EYFTFPASKSQDRMA
K1244	YFTFPASKSQDRMAP
S1245	FTFPASKSQDRMAPV
Y1259	VQNQWPNYEEKPHMH
T1267	EEKPHMHTESDHASI
S1282-p	AIQRVTRsQEELREE
Y1292-p	ELREEKVyQLERHRV
C1307	ESGMDRKCDSDMWIN
S1335	HLNHSSKSVTPASTL
T1337	NHSSKSVTPASTLTK
T1341	KSVTPASTLTKSGPG
T1343	VTPASTLTKSGPGRW
K1344	TPASTLTKSGPGRWK
T1359	TPAAVLPTPVAVSQP
Y1425	REEHQRWYEKEKARL
S1461	SLNPASFSPLATQAK
T1494	QPQQQPRTIERRDLQ
Y1502	IERRDLQYITISKEE
T1504	RRDLQYITISKEELS
S1506	DLQYITISKEELSSG
S1517	LSSGDSLSPDPWKRD
Y1661	KRRQEEGYYSRLEAE
Y1662	RRQEEGYYSRLEAER
S1663	RQEEGYYSRLEAERR
Y1697	RPPLPQDYEPPSQSS
S1701	PQDYEPPSQSSAPSA
S1703	DYEPPSQSSAPSAPP
K1721	QRNASYLKTQVLSPD
S1726	YLKTQVLSPDSLFTA
S1758	GPNSYSGSAGTTAGT
Y1766	AGTTAGTYDAPRDTR
S1779	TREKLSRSQDADLPG
L1784	SRSQDADLPGSSGAP
S1787	QDADLPGSSGAPENL
S1788	DADLPGSSGAPENLT
S1804-p	RERQRLFsQGQDVSD
T1820	VKASRKLTELENELN
K1829	LENELNTK_______

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