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Protein Page:
MAG (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MAG Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid. Binds to RTN4R. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion
Cellular Component: paranode region of axon; plasma membrane; integral to membrane
Biological Process: substantia nigra development; nerve growth factor receptor signaling pathway; negative regulation of axonogenesis; blood coagulation; cell adhesion; regulation of axonogenesis; leukocyte migration
Reference #:  P20916 (UniProtKB)
Alt. Names/Synonyms: GMA; MAG; myelin associated glycoprotein; Myelin-associated glycoprotein; S-MAG; sialic acid binding Ig-like lectin 4A; sialic acid-binding immunoglobulin-like lectin 4A; Siglec-4a; SIGLEC4A
Gene Symbols: MAG
Molecular weight: 69,069 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 10 K540 ITQTRRKKNVtESPs
0 2 T543-p TRRKKNVtESPsFSA
0 5 S547-p KNVtESPsFSAGDNP
0 3 S549 VtESPsFSAGDNPPV
0 2 S565 FSSDFRISGAPEKYE
0 10 K570 RISGAPEKYESERRL
0 1 R575 PEKYESERRLGSERR
0 4 P590 LLGLRGEPPELDLSY
0 1 K604 YSHSDLGKRPTKDSY
0 1 T607 SDLGKRPTKDSYTLT
0 1 K608 DLGKRPTKDSYTLTE
0 1 Y611 KRPTKDSYTLTEELA
1 0 Y620 LTEELAEYAEIRVK_
  mouse

► Hide Isoforms
 
K540-u ITQTRRKkNVTESSs
T543 TRRKkNVTESSsFsG
S547-p kNVTESSsFsGGDNP
S549-p VTESSsFsGGDNPHV
S565-p YSPEFRIsGAPDkYE
K570-u RIsGAPDkYESEKRL
K575 PDkYESEKRLGSERR
S590-p LLGLRGEsPELDLSY
K604-u YSHSDLGkRPtkDSy
T607-p SDLGkRPtkDSyTLT
K608-u DLGkRPtkDSyTLTE
Y611-p kRPtkDSyTLTEELA
Y620 LTEELAEYAEIRVK_
  MAG iso2  
K540 ITQTRRKKNVTESSS
T543 TRRKKNVTESSSFSG
S547 KNVTESSSFSGGDNP
S549 VTESSSFSGGDNPHV
S565-p YSPEFRIsGAPDkYE
K570-u RIsGAPDkYESREVS
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  MAG iso3  
K498 ITQTRRKKNVTESSS
T501 TRRKKNVTESSSFSG
S505 KNVTESSSFSGGDNP
S507 VTESSSFSGGDNPHV
S523 YSPEFRISGAPDKYE
K528 RISGAPDKYESEkQR
K533-u PDKYESEkQRLGSER
S549 LLGLRGESPELDLSY
K563 YSHSDLGKRPTK___
T566 SDLGKRPTK______
K567 DLGKRPTK_______
- gap
- gap
  rat

 
K540 ITQTRRKKNVTESPS
T543 TRRKKNVTESPSFSA
S547 KNVTESPSFSAGDNP
S549 VTESPSFSAGDNPHV
S565 YSPEFRISGAPDKYE
K570 RISGAPDKYESEKRL
K575 PDKYESEKRLGSERR
P590 LLGLRGEPPELDLSY
K604 YSHSDLGKRPTKDSY
T607 SDLGKRPTKDSYTLT
K608 DLGKRPTKDSYTLTE
Y611 KRPTKDSYTLTEELA
Y620-p LTEELAEyAEIRVK_
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