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Protein Page:
CKM (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CKM Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Kinase, other; EC 2.7.3.2
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: cytosol
Molecular Function: creatine kinase activity; ATP binding
Biological Process: phosphocreatine biosynthetic process; phosphorylation; creatine metabolic process
Reference #:  P06732 (UniProtKB)
Alt. Names/Synonyms: CKM; CKMM; Creatine kinase M chain; Creatine kinase M-type; creatine kinase, muscle; creatine kinase-M; KCRM; M-CK
Gene Symbols: CKM
Molecular weight: 43,101 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Select Structure to View Below

CKM

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K9 PFGNTHNKFKLNyKP
0 1 K9 PFGNTHNKFKLNyKP
0 1 K11 GNTHNKFKLNyKPEE
0 1 K11 GNTHNKFKLNyKPEE
0 1 K11 GNTHNKFKLNyKPEE
0 9 Y14-p HNKFKLNyKPEEEyP
0 1 K15 NKFKLNyKPEEEyPD
0 4 K15 NKFKLNyKPEEEyPD
0 56 Y20-p NyKPEEEyPDLsKHN
0 3 S24-p EEEyPDLsKHNNHMA
0 1 K25 EEyPDLsKHNNHMAK
0 1 K25 EEyPDLsKHNNHMAK
0 1 K32 KHNNHMAKVLtLELy
0 1 K32 KHNNHMAKVLtLELy
0 3 T35-p NHMAKVLtLELykkL
0 3 Y39-p KVLtLELykkLRDKE
0 48 K40-ac VLtLELykkLRDKET
0 2 K41-ac LtLELykkLRDKETP
0 3 K41 LtLELykKLRDKETP
0 1 K101 SDRHGGYKPTDKHKT
0 1 K101 SDRHGGYKPTDKHKT
0 2 K105 GGYKPTDKHKTDLNH
0 2 K107 YKPTDKHKTDLNHEN
0 2 K116 DLNHENLKGGDDLDP
0 2 K116 DLNHENLKGGDDLDP
0 153 Y125-p GDDLDPNyVLssRVR
1 2 S128-p LDPNyVLssRVRTGR
0 1 S129-p DPNyVLssRVRTGRs
0 2 S136-p sRVRTGRsIKGytLP
0 1 K138 VRTGRsIKGytLPPH
0 102 Y140-p TGRsIKGytLPPHCS
0 62 T141-p GRsIKGytLPPHCSR
0 1 K156 GERRAVEKLSVEALN
0 2 K156 GERRAVEKLSVEALN
0 3 S164-p LSVEALNsLtGEFkG
0 3 T166-p VEALNsLtGEFkGKy
0 46 K170-ac NsLtGEFkGKyyPLK
0 1 K170 NsLtGEFKGKyyPLK
0 1 K172 LtGEFkGKyyPLKsM
0 17 Y173-p tGEFkGKyyPLKsMt
0 122 Y174-p GEFkGKyyPLKsMtE
0 1 S178-p GKyyPLKsMtEKEQQ
0 1 T180-p yyPLKsMtEKEQQQL
0 1 K196 DDHFLFDKPVsPLLL
0 1 K196 DDHFLFDKPVsPLLL
0 2 S199-p FLFDKPVsPLLLASG
0 1 K223 GIWHNDNKSFLVWVN
0 3 K242 LRVISMEKGGNMkEV
0 1 K247-ac MEKGGNMkEVFRRFC
0 1 K247 MEKGGNMKEVFRRFC
0 1 K259 RFCVGLQKIEEIFkK
0 2 K259 RFCVGLQKIEEIFkK
0 47 K265-ac QKIEEIFkKAGHPFM
0 2 K265 QKIEEIFKKAGHPFM
0 2 K266 KIEEIFkKAGHPFMW
0 10 Y279-p MWNQHLGyVLTCPSN
1 1 T282 QHLGyVLTCPSNLGT
1 0 S285 GyVLTCPSNLGTGLR
1 0 T289 TCPSNLGTGLRGGVH
0 1 K298 LRGGVHVKLAHLSKH
0 1 K298 LRGGVHVKLAHLSKH
0 1 K304 VKLAHLSKHPKFEEI
0 2 K304 VKLAHLSKHPKFEEI
0 1 K307 AHLSKHPKFEEILtR
0 2 K307 AHLSKHPKFEEILtR
0 1 T313-p PKFEEILtRLRLQKR
0 2 T322-p LRLQKRGtGGVDtAA
0 1 T327-p RGtGGVDtAAVGsVF
0 1 S332-p VDtAAVGsVFDVSNA
0 4 K365-ac KLMVEMEkKLEKGQs
0 2 K369 EMEkKLEKGQsIDDM
0 2 S372-p kKLEKGQsIDDMIPA
0 1 K381 DDMIPAQK_______
  mouse

 
K9-ac PFGNTHNkFkLNYkP
K9-ub PFGNTHNkFkLNYkP
K11-ac GNTHNkFkLNYkPQE
K11-m1 GNTHNkFkLNYkPQE
K11-ub GNTHNkFkLNYkPQE
Y14 HNkFkLNYkPQEEYP
K15-ac NkFkLNYkPQEEYPD
K15-ub NkFkLNYkPQEEYPD
Y20 NYkPQEEYPDLSkHN
S24 QEEYPDLSkHNNHMA
K25-ac EEYPDLSkHNNHMAk
K25-ub EEYPDLSkHNNHMAk
K32-ac kHNNHMAkVLtPDLY
K32-ub kHNNHMAkVLtPDLY
T35-p NHMAkVLtPDLYNkL
Y39 kVLtPDLYNkLRDKE
N40 VLtPDLYNkLRDKET
K41-ac LtPDLYNkLRDKETP
K41-ub LtPDLYNkLRDKETP
K101-ac QDRHGGYkPTDkHkT
K101-ub QDRHGGYkPTDkHkT
K105-ub GGYkPTDkHkTDLNH
K107-ub YkPTDkHkTDLNHEN
K116-ac DLNHENLkGGDDLDP
K116-ub DLNHENLkGGDDLDP
Y125-p GDDLDPNyVLSSRVR
S128 LDPNyVLSSRVRTGR
S129 DPNyVLSSRVRTGRS
S136 SRVRTGRSIkGytLP
K138-ub VRTGRSIkGytLPPH
Y140-p TGRSIkGytLPPHCS
T141-p GRSIkGytLPPHCSR
K156-ac GERRAVEkLSVEALN
K156-ub GERRAVEkLSVEALN
S164-p LSVEALNsLtGEFkG
T166-p VEALNsLtGEFkGkY
K170-ac NsLtGEFkGkYyPLK
K170-ub NsLtGEFkGkYyPLK
K172-ac LtGEFkGkYyPLKSM
Y173 tGEFkGkYyPLKSMT
Y174-p GEFkGkYyPLKSMTE
S178 GkYyPLKSMTEQEQQ
T180 YyPLKSMTEQEQQQL
K196-ac DDHFLFDkPVsPLLL
K196-ub DDHFLFDkPVsPLLL
S199-p FLFDkPVsPLLLASG
K223-ub GIWHNDNkSFLVWVN
K242-ac LRVISMEkGGNMkEV
K247 MEkGGNMKEVFRRFC
K247-ub MEkGGNMkEVFRRFC
K259-ac RFCVGLQkIEEIFkk
K259-ub RFCVGLQkIEEIFkk
K265-ac QkIEEIFkkAGHPFM
K265-ub QkIEEIFkkAGHPFM
K266-ub kIEEIFkkAGHPFMW
Y279 MWNEHLGYVLtCPSN
T282-p EHLGYVLtCPSNLGT
S285 GYVLtCPSNLGTGLR
T289 tCPSNLGTGLRGGVH
K298-ac LRGGVHVkLANLSkH
K298-ub LRGGVHVkLANLSkH
K304-ac VkLANLSkHPkFEEI
K304-ub VkLANLSkHPkFEEI
K307-ac ANLSkHPkFEEILTR
K307-ub ANLSkHPkFEEILTR
T313 PkFEEILTRLRLQKR
T322-p LRLQKRGtGGVDtAA
T327-p RGtGGVDtAAVGAVF
A332 VDtAAVGAVFDISNA
K365-ac KLMVEMEkKLEkGQs
K369-ub EMEkKLEkGQsIDDM
S372-p kKLEkGQsIDDMIPA
K381-ub DDMIPAQk_______
  rat

 
K9 PFGNTHNKFkLNYKP
K9 PFGNTHNKFkLNYKP
K11-ac GNTHNKFkLNYKPQE
K11 GNTHNKFKLNYKPQE
K11 GNTHNKFKLNYKPQE
Y14 HNKFkLNYKPQEEYP
K15 NKFkLNYKPQEEYPD
K15 NKFkLNYKPQEEYPD
Y20 NYKPQEEYPDLSKHN
S24 QEEYPDLSKHNNHMA
K25 EEYPDLSKHNNHMAk
K25 EEYPDLSKHNNHMAk
K32-ac KHNNHMAkVLtPDLy
K32 KHNNHMAKVLtPDLy
T35-p NHMAkVLtPDLyNkL
Y39-p kVLtPDLyNkLRDKE
N40 VLtPDLyNkLRDKET
K41-ac LtPDLyNkLRDKETP
K41 LtPDLyNKLRDKETP
K101 QDRHGGYKPTDKHKT
K101 QDRHGGYKPTDKHKT
K105 GGYKPTDKHKTDLNH
K107 YKPTDKHKTDLNHEN
K116-ac DLNHENLkGGDDLDP
K116 DLNHENLKGGDDLDP
Y125-p GDDLDPNyVLssRVR
S128-p LDPNyVLssRVRTGR
S129-p DPNyVLssRVRTGRS
S136 sRVRTGRSIKGytLP
K138 VRTGRSIKGytLPPH
Y140-p TGRSIKGytLPPHCS
T141-p GRSIKGytLPPHCSR
K156-ac GERRAVEkLSVEALN
K156 GERRAVEKLSVEALN
S164 LSVEALNSLtGEFKG
T166-p VEALNSLtGEFKGkY
K170 NSLtGEFKGkYyPLK
K170 NSLtGEFKGkYyPLK
K172-ac LtGEFKGkYyPLKsM
Y173 tGEFKGkYyPLKsMt
Y174-p GEFKGkYyPLKsMtE
S178-p GkYyPLKsMtEQEQQ
T180-p YyPLKsMtEQEQQQL
K196-ac DDHFLFDkPVsPLLL
K196 DDHFLFDKPVsPLLL
S199-p FLFDkPVsPLLLASG
K223 GIWHNDNKSFLVWVN
K242-ac LRVISMEkGGNMkEV
K247-ac MEkGGNMkEVFRRFC
K247 MEkGGNMKEVFRRFC
K259 RFCVGLQKIEEIFkK
K259 RFCVGLQKIEEIFkK
K265-ac QKIEEIFkKAGHPFM
K265 QKIEEIFKKAGHPFM
K266 KIEEIFkKAGHPFMW
Y279-p MWNEHLGyVLTCPSN
T282 EHLGyVLTCPSNLGT
S285 GyVLTCPSNLGTGLR
T289 TCPSNLGTGLRGGVH
K298-ac LRGGVHVkLANLSkH
K298 LRGGVHVKLANLSkH
K304-ac VkLANLSkHPkFEEI
K304 VkLANLSKHPkFEEI
K307-ac ANLSkHPkFEEILtR
K307 ANLSkHPKFEEILtR
T313-p PkFEEILtRLRLQKR
T322-p LRLQKRGtGGVDTAA
T327 RGtGGVDTAAVGAVF
A332 VDTAAVGAVFDISNA
K365 KLMVEMEKKLEKGQs
K369 EMEKKLEKGQsIDDM
S372-p KKLEKGQsIDDMIPA
K381 DDMIPAQK_______
  chicken

 
K9 PFSSTHNKHKLKFSA
K9 PFSSTHNKHKLKFSA
K11 SSTHNKHKLKFSAEE
K11 SSTHNKHKLKFSAEE
K11 SSTHNKHKLKFSAEE
F14 HNKHKLKFSAEEEFP
S15 NKHKLKFSAEEEFPD
S15 NKHKLKFSAEEEFPD
F20 KFSAEEEFPDLSKHN
S24 EEEFPDLSKHNNHMA
K25 EEFPDLSKHNNHMAK
K25 EEFPDLSKHNNHMAK
K32 KHNNHMAKVLTPELY
K32 KHNNHMAKVLTPELY
T35 NHMAKVLTPELYKRL
Y39 KVLTPELYKRLRDKE
K40 VLTPELYKRLRDKET
R41 LTPELYKRLRDKETP
R41 LTPELYKRLRDKETP
K101 QDRHGGYKPTDKHRT
K101 QDRHGGYKPTDKHRT
K105 GGYKPTDKHRTDLNH
R107 YKPTDKHRTDLNHEN
K116 DLNHENLKGGDDLDP
K116 DLNHENLKGGDDLDP
Y125 GDDLDPKYVLSSRVR
S128 LDPKYVLSSRVRTGR
S129 DPKYVLSSRVRTGRS
S136 SRVRTGRSIKGYSLP
K138 VRTGRSIKGYSLPPH
Y140 TGRSIKGYSLPPHCS
S141 GRSIKGYSLPPHCSR
K156 GERRAVEKLSVEALN
K156 GERRAVEKLSVEALN
S164 LSVEALNSLEGEFKG
E166 VEALNSLEGEFKGRY
K170 NSLEGEFKGRYYPLK
K170 NSLEGEFKGRYYPLK
R172 LEGEFKGRYYPLKAM
Y173 EGEFKGRYYPLKAMT
Y174 GEFKGRYYPLKAMTE
A178 GRYYPLKAMTEQEQQ
T180 YYPLKAMTEQEQQQL
K196 DDHFLFDKPVSPLLL
K196 DDHFLFDKPVSPLLL
S199 FLFDKPVSPLLLASG
K223 GIWHNDNKTFLVWVN
K242 LRVISMEKGGNMKEV
K247 MEKGGNMKEVFRRFC
K247 MEKGGNMKEVFRRFC
K259 RFCVGLKKIEEIFKK
K259 RFCVGLKKIEEIFKK
K265 KKIEEIFKKAGHPFM
K265 KKIEEIFKKAGHPFM
K266 KIEEIFKKAGHPFMW
Y279 MWTEHLGYILtCPsN
T282-p EHLGYILtCPsNLGt
S285-p GYILtCPsNLGtGLR
T289-p tCPsNLGtGLRGGVH
K298 LRGGVHVKLPKLSQH
K298 LRGGVHVKLPKLSQH
Q304 VKLPKLSQHPKFEEI
Q304 VKLPKLSQHPKFEEI
K307 PKLSQHPKFEEILHR
K307 PKLSQHPKFEEILHR
H313 PKFEEILHRLRLQKR
T322 LRLQKRGTGGVDTAA
T327 RGTGGVDTAAVGAVF
A332 VDTAAVGAVFDISNA
K365 KLMVEMEKKLEQNQP
Q369 EMEKKLEQNQPIDDM
P372 KKLEQNQPIDDMIPA
K381 DDMIPAQK_______
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