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Protein Page:
PCYT1A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PCYT1A Controls phosphatidylcholine synthesis. Homodimer. By phosphorylation. Belongs to the cytidylyltransferase family. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.7.15; Transferase; Lipid Metabolism - glycerophospholipid
Cellular Component: endoplasmic reticulum membrane; glycogen granule; cytosol
Molecular Function: choline-phosphate cytidylyltransferase activity; lipid binding
Biological Process: CDP-choline pathway; response to abiotic stimulus; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine biosynthetic process
Reference #:  P49585 (UniProtKB)
Alt. Names/Synonyms: CCT A; CCT-alpha; CCTA; Choline-phosphate cytidylyltransferase A; CT; CT A; CTA; CTP:phosphocholine cytidylyltransferase A; CTPCT; PCY1A; PCYT1; PCYT1A; phosphate cytidylyltransferase 1, choline, alpha; Phosphorylcholine transferase A
Gene Symbols: PCYT1A
Molecular weight: 41,731 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PCYT1A
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K8-a MDAQCSAkVNARKRR
0 1 A11 QCSAkVNARKRRKEA
0 1 K33-u EEDGVPSkVQRCAVG
1 1 K57-u EIEVDFSkPYVRVTM
0 1 Y141-p DAVQHCRyVDEVVRN
0 1 K186-u DDVYKHIkEAGMFAP
0 7 S233-p TAKELNVsFINEKKY
0 1 Y240 sFINEKKYHLQERVD
0 9 K270-u FVQKVEEkSIDLIQK
0 1 K281 LIQKWEEKSREFIGS
2 36 S315-p GRMLQAIsPKQsPss
1 22 S319-p QAIsPKQsPsssPtR
1 1 S321-p IsPKQsPsssPtRER
1 2 S322-p sPKQsPsssPtRERs
1 10 S323-p PKQsPsssPtRERsP
0 5 T325-p QsPsssPtRERsPsP
1 6 S329-p ssPtRERsPsPsFRW
1 23 S331-p PtRERsPsPsFRWPF
1 4 S333-p RERsPsPsFRWPFsG
0 4 S339-p PsFRWPFsGKtsPPC
0 1 K341 FRWPFsGKtsPPCsP
0 22 T342-p RWPFsGKtsPPCsPA
1 26 S343-p WPFsGKtsPPCsPAN
1 3 P345 FsGKtsPPCsPANLs
1 3 C346 sGKtsPPCsPANLsR
1 34 S347-p GKtsPPCsPANLsRH
1 3 N350 sPPCsPANLsRHKAA
1 5 S352-p PCsPANLsRHKAAAy
0 11 A358 LsRHKAAAyDIsEDE
0 29 Y359-p sRHKAAAyDIsEDEE
1 65 S362-p KAAAyDIsEDEED__
  mouse

 
K8 MDAQSSAKVNsRKRR
S11-p QSSAKVNsRKRRKEA
K33 EEDGIPSKVQRCAVG
K57 EIEVDFSKPYVRVTM
Y141 DAVQHCRYVDEVVRN
K186 DDVYKHIKDAGMFAP
S233-p TAKELNVsFINEKKy
Y240-p sFINEKKyHLQERVD
K270 FVQKVEEKSIDLIQK
K281-u LIQKWEEkSREFIGS
S315-p GRMLQAIsPKQsPss
S319-p QAIsPKQsPsssPtH
S321-p IsPKQsPsssPtHER
S322-p sPKQsPsssPtHERs
S323-p PKQsPsssPtHERsP
T325-p QsPsssPtHERsPsP
S329-p ssPtHERsPsPsFRW
S331-p PtHERsPsPsFRWPF
S333-p HERsPsPsFRWPFsG
S339-p PsFRWPFsGktsPss
K341-u FRWPFsGktsPsssP
T342-p RWPFsGktsPsssPA
S343-p WPFsGktsPsssPAs
S345-p FsGktsPsssPAsLs
S346-p sGktsPsssPAsLsR
S347-p GktsPsssPAsLsRC
S350-p sPsssPAsLsRCRAV
S352-p sssPAsLsRCRAVtC
T358-p LsRCRAVtCDIsEDE
C359 sRCRAVtCDIsEDEE
S362-p RAVtCDIsEDEED__
  rat

 
K8 MDAQSSAKVNSRKRR
S11 QSSAKVNSRKRRKEV
K33 EEDGIPSKVQRCAVG
K57 EIEVDFSKPYVRVTM
Y141 DAVQHCRYVDEVVRN
K186 DDVYKHIKEAGMFAP
S233 TAKELNVSFINEKKY
Y240 SFINEKKYHLQERVD
K270 FVQKVEEKSIDLIQK
K281 LIQKWEEKSREFIGS
S315-p GRMLQAIsPKQsPss
S319-p QAIsPKQsPsssPTH
S321-p IsPKQsPsssPTHER
S322-p sPKQsPsssPTHERs
S323-p PKQsPsssPTHERsP
T325 QsPsssPTHERsPsP
S329-p ssPTHERsPsPsFRW
S331-p PTHERsPsPsFRWPF
S333-p HERsPsPsFRWPFSG
S339 PsFRWPFSGKtsPss
K341 FRWPFSGKtsPsssP
T342-p RWPFSGKtsPsssPA
S343-p WPFSGKtsPsssPAs
S345-p FSGKtsPsssPAsLs
S346-p SGKtsPsssPAsLsR
S347-p GKtsPsssPAsLsRC
S350-p sPsssPAsLsRCKAV
S352-p sssPAsLsRCKAVTC
T358 LsRCKAVTCDIsEDE
C359 sRCKAVTCDIsEDEE
S362-p KAVTCDIsEDEED__
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