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Smad2 (human)

Overview Smad2 ubiquitously expressed transcription factor phosphorylated and activated by TGF-beta receptor-type kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus Molecular Function: protein binding; DNA binding; transcription activator binding; ubiquitin protein ligase binding; double-stranded DNA binding; chromatin binding; SMAD binding; transcription factor activity; transcription factor binding; transforming growth factor beta receptor binding; phosphatase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Biological Process: developmental growth; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; paraxial mesoderm morphogenesis; gastrulation; primary microRNA processing; palate development; negative regulation of transcription from RNA polymerase II promoter; post-embryonic development; anterior/posterior pattern formation; negative regulation of cell proliferation; regulation of transforming growth factor beta receptor signaling pathway; ureteric bud development; transforming growth factor beta receptor signaling pathway; pancreas development; embryonic foregut morphogenesis; response to glucose stimulus; positive regulation of BMP signaling pathway; pericardium development; transcription initiation from RNA polymerase II promoter; cell fate commitment; transcription, DNA-dependent; regulation of binding; in utero embryonic development; common-partner SMAD protein phosphorylation; embryonic cranial skeleton morphogenesis; SMAD protein complex assembly; organ growth; zygotic determination of dorsal/ventral axis; mesoderm formation; insulin secretion; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; lung development; endoderm development Reference #:  Q15796 (UniProtKB) Alt. Names/Synonyms: hMAD-2; hSMAD2; JV18; JV18-1; MAD homolog 2; Mad protein homolog; MAD, mothers against decapentaplegic homolog 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; SMAD2 Gene Symbols: SMAD2 Molecular weight: 52,306 Da Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Smad2 1DEV - A/C=261-456 (human) 1KHX - A=241-466 (human) 1U7V - A/C=270-466 (human) 2LB3 - B=217-224 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1DEV 1KHX 1U7V 2LB3  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: S245‑p, S250‑p, S255‑p transcription, altered: T8‑p, T220‑p, S245‑p, S250‑p, S255‑p, S464‑p, S465‑p, S467‑p activation: T8‑p, T220‑p, S245‑p, S250‑p, S255‑p, S464‑p, S465‑p, S467‑p intracellular localization: S110‑p, T220‑p, S240‑p, S245‑p, S250‑p, S255‑p, S260‑p, S464‑p, S465‑p, S467‑p molecular association, regulation: T8‑p, S110‑p, T220‑p, S240‑p, S245‑p, S250‑p, S255‑p, S260‑p, S465‑p, S467‑p protein conformation: S245‑p, S250‑p, S255‑p protein stabilization: T8‑p, T220‑p, S245‑p, S250‑p, S255‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2-p	______MsSILPFtP
3	9		T8-p	MsSILPFtPPVVKRL
2	4		K19-a	VKRLLGWkkSAGGSG
1	0		K20-a	KRLLGWkkSAGGSGG
1	0		K39-a	EQNGQEEkWCEKAVK
0	14		Y102-p	QWDTTGLySFSEQTR
1	0		S110-p	SFSEQTRsLDGRLQV
0	1		K157-u	EYAFNLKkDEVCVNP
0	1		Y165-p	DEVCVNPyHYQRVEt
0	2		T172-p	yHYQRVEtPVLPPVL
1	0		T197-p	LPPLDDYtHSIPENT
6	0		T220-p	QSNYIPEtPPPGYIS
2	0		S240-p	SDQQLNQsMDTGsPA
5	0		S245-p	NQsMDTGsPAELsPT
3	0		S250-p	TGsPAELsPTTLsPV
4	0		S255-p	ELsPTTLsPVNHsLD
1	0		S260-p	TLsPVNHsLDLQPVT
0	1		T324-p	SNVNRNAtVEMTRRH
1	0		S417-p	RMCTIRMsFVKGWGA
1	0		S433	YRRQTVTSTPCWIEL
0	4		S458-p	KVLTQMGsPsVRCss
0	2		S460-p	LTQMGsPsVRCssMs
5	1		S464-p	GsPsVRCssMs____
27	5		S465-p	sPsVRCssMs_____
27	5		S467-p	sVRCssMs_______

	mouse
S2	______MSSILPFtP
T8-p	MSSILPFtPPVVKRL
K19	VKRLLGWKKSAGGSG
K20	KRLLGWKKSAGGSGG
K39	EQNGQEEKWCEKAVK
Y102-p	QWDTTGLySFSEQTR
S110	SFSEQTRSLDGRLQV
K157	EYAFNLKKDEVCVNP
Y165	DEVCVNPYHYQRVEt
T172-p	YHYQRVEtPVLPPVL
T197	LPPLDDYTHSIPENT
T220	QSNYIPETPPPGYIS
S240	SDQQLNQSMDTGSPA
S245	NQSMDTGSPAELSPT
S250	TGSPAELSPTTLSPV
S255	ELSPTTLSPVNHSLD
S260	TLSPVNHSLDLQPVT
T324	SNVNRNATVEMTRRH
S417	RMCTIRMSFVKGWGA
S433-p	YRRQTVTsTPCWIEL
S458	KVLTQMGSPSVRCSs
S460	LTQMGSPSVRCSsMs
S464	GSPSVRCSsMs____
S465-p	SPSVRCSsMs_____
S467-p	SVRCSsMs_______

	rat
S2	______MSSILPFTP
T8	MSSILPFTPPVVKRL
K19	VKRLLGWKKSAGGSG
K20	KRLLGWKKSAGGSGG
K39	EQNGQEEKWCEKAVK
Y102	QWDTTGLYSFSEQTR
S110	SFSEQTRSLDGRLQV
K157	EYAFSLKKDEVCVNP
Y165	DEVCVNPYHYQRVET
T172	YHYQRVETPVLPPVL
T197	LPPLDDYTHSIPENT
T220	QSNYIPETPPPGYIS
S240	SDQQLNQSMDTGSPA
S245	NQSMDTGSPAELSPT
S250	TGSPAELSPTTLSPV
S255	ELSPTTLSPVNHSLD
S260	TLSPVNHSLDLQPVT
T324	SNVNRNATVEMTRRH
S417	RMCTIRMSFVKGWGA
S433	YRRQTVTSTPCWIEL
S458	KVLTQMGSPSVRCSs
S460	LTQMGSPSVRCSsMs
S464	GSPSVRCSsMs____
S465-p	SPSVRCSsMs_____
S467-p	SVRCSsMs_______

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