|
MAT1A
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD); also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. Belongs to the AdoMet synthase family. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.5.1.6; Transferase; Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - selenoamino acid |
|
Cellular Component: cytosol
|
|
Molecular Function: methionine adenosyltransferase activity; metal ion binding; ATP binding
|
|
Biological Process: methylation; amino acid metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process; methanogenesis; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process
|
|
Reference #:
Q00266 (UniProtKB)
|
| Alt. Names/Synonyms: AdoMet synthase 1; adoMet synthetase 1; AMS1; MAT; MAT 1; MAT-I/III; MAT1A; MATA1; Methionine adenosyltransferase 1; methionine adenosyltransferase I, alpha; Methionine adenosyltransferase I/III; METK1; S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthetase isoform type-1; SAMS; SAMS1 |
| Gene Symbols: MAT1A |
|
Molecular weight: 43,648 Da
|
|
Basal Isoelectric point: 5.86
Predict pI for various phosphorylation states
|
