Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD); also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. Belongs to the AdoMet synthase family. Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; Transferase; Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - selenoamino acid
Cellular Component: cytosol
Molecular Function: methionine adenosyltransferase activity; metal ion binding; ATP binding
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.