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Protein Page:
TPM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TPM1 a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1). Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin binding protein; Motor protein
Cellular Component: filamentous actin; sarcomere; cytoskeleton; stress fiber; muscle thin filament tropomyosin; cytosol
Molecular Function: structural constituent of cytoskeleton; structural constituent of muscle; cytoskeletal protein binding; actin binding
Biological Process: positive regulation of cell adhesion; wound healing; regulation of muscle contraction; in utero embryonic development; cytoskeleton organization and biogenesis; sarcomere organization; regulation of heart contraction; muscle filament sliding; muscle contraction; positive regulation of ATPase activity; positive regulation of stress fiber formation; ruffle organization and biogenesis; ventricular cardiac muscle morphogenesis; cell motility; negative regulation of cell migration; positive regulation of heart rate by epinephrine; cardiac muscle contraction
Reference #:  P09493 (UniProtKB)
Alt. Names/Synonyms: alpha tropomyosin; Alpha-tropomyosin; C15orf13; cardiomyopathy, hypertrophic 3; CMD1Y; HTM-alpha; sarcomeric tropomyosin kappa; TMSA; TPM1; tropomyosin 1 (alpha); Tropomyosin alpha-1 chain; Tropomyosin-1
Gene Symbols: TPM1
Molecular weight: 32,709 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TPM1

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, inhibited: S283‑p
cell motility, inhibited: S283‑p
intracellular localization: S61‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K7 _MDAIKKKMQMLkLD
0 1 K12-ac KKKMQMLkLDKENAL
0 1 K15 MQMLkLDKENALDRA
0 1 K15 MQMLkLDKENALDRA
0 3 K29-ac AEQAEADkkAAEDRS
0 6 K29-ub AEQAEADkkAAEDRS
0 15 K30-ub EQAEADkkAAEDRSk
0 6 K37-ub kAAEDRSkQLEDELV
0 5 S45-p QLEDELVsLQkKLKG
0 16 K48-ac DELVsLQkKLKGtED
0 1 K48 DELVsLQKKLKGtED
0 1 K49 ELVsLQkKLKGtEDE
0 1 K49 ELVsLQkKLKGtEDE
0 1 T53-p LQkKLKGtEDELDKy
0 2 K59 GtEDELDKysEALKD
0 19 Y60-p tEDELDKysEALKDA
1 7 S61-p EDELDKysEALKDAQ
0 2 K65 DKysEALKDAQEKLE
0 1 K77 KLELAEKKAtDAEAD
0 3 K77 KLELAEKKAtDAEAD
0 2 T79-p ELAEKKAtDAEADVA
0 1 - gap
0 16 S87-p DAEADVAsLNRRIQL
0 3 T108-p RAQERLAtALQkLEE
0 4 K112-ac RLAtALQkLEEAEkA
0 2 K112 RLAtALQKLEEAEkA
0 9 K118-ac QkLEEAEkAADESER
0 4 K118-ub QkLEEAEkAADESER
0 2 K128 DESERGMKVIESRAQ
0 1 K136 VIESRAQKDEEKMEI
0 1 K136 VIESRAQKDEEKMEI
0 1 K140 RAQKDEEKMEIQEIQ
0 1 K140 RAQKDEEKMEIQEIQ
0 2 K149-ac EIQEIQLkEAKHIAE
0 1 K149 EIQEIQLKEAKHIAE
0 2 K152 EIQLkEAKHIAEDAD
0 1 K152 EIQLkEAKHIAEDAD
0 5 K161-m1 IAEDADRkyEEVARK
0 1 K161 IAEDADRKyEEVARK
0 1 K161 IAEDADRKyEEVARK
0 348 Y162-p AEDADRkyEEVARKL
0 1 K168 kyEEVARKLVIIEsD
0 8 S174-p RKLVIIEsDLERAEE
0 1 S186 AEERAELSEGKCAEL
0 2 K189 RAELSEGKCAELEEE
0 2 K198 AELEEELKtVtNNLK
0 6 T199-p ELEEELKtVtNNLKs
0 3 T201-p EEELKtVtNNLKsLE
0 3 K205 KtVtNNLKsLEAQAE
0 1 K205 KtVtNNLKsLEAQAE
0 7 S206-p tVtNNLKsLEAQAEK
0 3 K213 sLEAQAEKysQKEDR
0 2 K213 sLEAQAEKysQKEDR
0 1 Y214-p LEAQAEKysQKEDRy
0 3 S215-p EAQAEKysQKEDRyE
0 2 K217 QAEKysQKEDRyEEE
0 1 K217 QAEKysQKEDRyEEE
0 1 R220 KysQKEDRyEEEIKV
0 8 Y221-p ysQKEDRyEEEIKVL
0 2 K226 DRyEEEIKVLSDKLK
0 1 K231 EIKVLSDKLKEAETR
0 1 K233 KVLSDKLKEAETRAE
0 4 K233 KVLSDKLKEAETRAE
0 1 K248 FAERSVTKLEKsIDD
0 1 K248 FAERSVTKLEKsIDD
0 2 K251 RSVTKLEKsIDDLED
0 2 K251 RSVTKLEKsIDDLED
0 9 S252-p SVTKLEKsIDDLEDE
0 87 Y261-p DDLEDELyAQKLKyK
0 2 K264 EDELyAQKLKyKAIS
0 1 K264 EDELyAQKLKyKAIS
0 1 K266 ELyAQKLKyKAISEE
0 1 K266 ELyAQKLKyKAISEE
0 6 Y267-p LyAQKLKyKAISEEL
0 3 K268 yAQKLKyKAISEELD
0 1 S271 KLKyKAISEELDHAL
0 10 T282-p DHALNDMtsI_____
9 104 S283-p HALNDMtsI______
  TPM1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K20 SEHLHERKLRETAEA
S31-p TAEADVAsLNRRIQL
T52 RAQERLATALQKLEE
K56 RLATALQKLEEAEKA
K56 RLATALQKLEEAEKA
K62 QKLEEAEKAADESER
K62 QKLEEAEKAADESER
K72 DESERGMKVIESRAQ
K80 VIESRAQKDEEKMEI
K80 VIESRAQKDEEKMEI
K84 RAQKDEEKMEIQEIQ
K84 RAQKDEEKMEIQEIQ
K93 EIQEIQLKEAKHIAE
K93 EIQEIQLKEAKHIAE
K96 EIQLKEAKHIAEDAD
K96 EIQLKEAKHIAEDAD
K105 IAEDADRKYEEVARK
K105 IAEDADRKYEEVARK
K105 IAEDADRKYEEVARK
Y106 AEDADRKYEEVARKL
K112 KYEEVARKLVIIESD
S118 RKLVIIESDLERAEE
S130 AEERAELSEGQVRQL
Q133 RAELSEGQVRQLEEQ
R142 RQLEEQLRIMDSDLE
I143 QLEEQLRIMDSDLEs
D145 EEQLRIMDSDLEsIN
E149 RIMDSDLEsINAAED
E149 RIMDSDLEsINAAED
S150-p IMDSDLEsINAAEDK
K157 sINAAEDKYSQKEDR
K157 sINAAEDKYSQKEDR
Y158 INAAEDKYSQKEDRY
S159 NAAEDKYSQKEDRYE
K161 AEDKYSQKEDRYEEE
K161 AEDKYSQKEDRYEEE
R164 KYSQKEDRYEEEIKV
Y165 YSQKEDRYEEEIKVL
K170 DRYEEEIKVLSDKLK
K175 EIKVLSDKLKEAETR
K177 KVLSDKLKEAETRAE
K177 KVLSDKLKEAETRAE
K192 FAERSVTKLEksIDD
K192 FAERSVTKLEksIDD
K195 RSVTKLEKsIDDLEE
K195-ac RSVTKLEksIDDLEE
S196-p SVTKLEksIDDLEEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TPM1 iso3  
K7 _MDAIKKKMQMLKLD
K12 KKKMQMLKLDKENAL
K15 MQMLKLDKENALDRA
K15 MQMLKLDKENALDRA
K29-ac AEQAEADkKAAEDRS
K29 AEQAEADKKAAEDRS
K30 EQAEADkKAAEDRSK
K37 KAAEDRSKQLEDELV
S45 QLEDELVSLQKKLKG
K48 DELVSLQKKLKGTED
K48 DELVSLQKKLKGTED
K49 ELVSLQKKLKGTEDE
K49 ELVSLQKKLKGTEDE
T53 LQKKLKGTEDELDKY
K59 GTEDELDKYSEALKD
Y60 TEDELDKYSEALKDA
S61 EDELDKYSEALKDAQ
K65 DKYSEALKDAQEKLE
K77 KLELAEKKATDAEAD
K77 KLELAEKKATDAEAD
T79 ELAEKKATDAEADVA
- gap
S87 DAEADVASLNRRIQL
T108 RAQERLATALQKLEE
K112 RLATALQKLEEAEKA
K112 RLATALQKLEEAEKA
K118 QKLEEAEKAADESER
K118 QKLEEAEKAADESER
K128 DESERGMKVIESRAQ
K136 VIESRAQKDEEKMEI
K136 VIESRAQKDEEKMEI
K140 RAQKDEEKMEIQEIQ
K140 RAQKDEEKMEIQEIQ
K149 EIQEIQLKEAKHIAE
K149 EIQEIQLKEAKHIAE
K152 EIQLKEAKHIAEDAD
K152 EIQLKEAKHIAEDAD
K161 IAEDADRKyEEVARK
K161 IAEDADRKyEEVARK
K161 IAEDADRKyEEVARK
Y162-p AEDADRKyEEVARKL
K168 KyEEVARKLVIIESD
S174 RKLVIIESDLERAEE
S186 AEERAELSEGQVRQL
Q189 RAELSEGQVRQLEEQ
R198 RQLEEQLRIMDQTLK
I199 QLEEQLRIMDQTLKA
D201 EEQLRIMDQTLKALM
K205 RIMDQTLKALMAAED
K205 RIMDQTLKALMAAED
A206 IMDQTLKALMAAEDk
K213-ac ALMAAEDkYSQKEDR
K213 ALMAAEDKYSQKEDR
Y214 LMAAEDkYSQKEDRY
S215 MAAEDkYSQKEDRYE
K217 AEDkYSQKEDRYEEE
K217 AEDkYSQKEDRYEEE
R220 kYSQKEDRYEEEIKV
Y221 YSQKEDRYEEEIKVL
K226 DRYEEEIKVLSDKLK
K231 EIKVLSDKLKEAETR
K233 KVLSDKLKEAETRAE
K233 KVLSDKLKEAETRAE
K248 FAERSVTKLEksIDD
K248 FAERSVTKLEksIDD
K251 RSVTKLEKsIDDLEE
K251-ac RSVTKLEksIDDLEE
S252-p SVTKLEksIDDLEEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TPM1 iso6  
K7 _MDAIKKKMQMLKLD
K12 KKKMQMLKLDKENAL
K15 MQMLKLDKENALDRA
K15 MQMLKLDKENALDRA
K29 AEQAEADKKAAEDRS
K29 AEQAEADKKAAEDRS
K30 EQAEADKKAAEDRSK
K37 KAAEDRSKQLEEDIA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S87 KAEADVASLNRRIQL
T108 RAQERLATALQKLEE
K112 RLATALQKLEEAEKA
K112 RLATALQKLEEAEKA
K118 QKLEEAEKAADESER
K118 QKLEEAEKAADESER
K128 DESERGMKVIESRAQ
K136 VIESRAQKDEEKMEI
K136 VIESRAQKDEEKMEI
K140 RAQKDEEKMEIQEIQ
K140 RAQKDEEKMEIQEIQ
K149 EIQEIQLKEAKHIAE
K149 EIQEIQLKEAKHIAE
K152 EIQLKEAKHIAEDAD
K152 EIQLKEAKHIAEDAD
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
Y162 AEDADRKYEEVARKL
K168 KYEEVARKLVIIESD
S174 RKLVIIESDLERAEE
S186 AEERAELSEGKCAEL
K189 RAELSEGKCAELEEE
K198 AELEEELKTVTNNLK
T199 ELEEELKTVTNNLKS
T201 EEELKTVTNNLKSLE
K205 KTVTNNLKSLEAQAE
K205 KTVTNNLKSLEAQAE
S206 TVTNNLKSLEAQAEK
K213 SLEAQAEKYSQKEDR
K213 SLEAQAEKYSQKEDR
Y214 LEAQAEKYSQKEDRY
S215 EAQAEKYSQKEDRYE
K217 QAEKYSQKEDRYEEE
K217 QAEKYSQKEDRYEEE
R220 KYSQKEDRYEEEIKV
Y221 YSQKEDRYEEEIKVL
K226 DRYEEEIKVLSDKLK
K231 EIKVLSDKLKEAETR
K233 KVLSDKLKEAETRAE
K233 KVLSDKLKEAETRAE
K248 FAERSVTKLEKSIDD
K248 FAERSVTKLEKSIDD
K251 RSVTKLEKSIDDLED
K251 RSVTKLEKSIDDLED
S252 SVTKLEKSIDDLEDE
Y261 DDLEDELYAQKLKYK
K264 EDELYAQKLKYKAIS
K264 EDELYAQKLKYKAIS
K266 ELYAQKLKYKAISEE
K266 ELYAQKLKYKAISEE
Y267 LYAQKLKYKAISEEL
K268 YAQKLKYKAISEELD
S271 KLKYKAISEELDHAL
T282 DHALNDMTSI_____
S283 HALNDMTSI______
  mouse

► Hide Isoforms
 
K7-ub _MDAIKKkMQMLKLD
K12 KKkMQMLKLDkENAL
K15-ub MQMLKLDkENALDRA
K15-ac MQMLKLDkENALDRA
K29 AEQAEADKkAAEDRS
K29-ub AEQAEADkkAAEDRS
K30-ub EQAEADkkAAEDRSk
K37-ub kAAEDRSkQLEDELV
S45-p QLEDELVsLQkkLKG
K48-ac DELVsLQkkLKGTED
K48-ub DELVsLQkkLKGTED
K49-ac ELVsLQkkLKGTEDE
K49-ub ELVsLQkkLKGTEDE
T53 LQkkLKGTEDELDky
K59-ac GTEDELDkysEALkD
Y60-p TEDELDkysEALkDA
S61-p EDELDkysEALkDAQ
K65-ub DkysEALkDAQEKLE
K77-ac KLELAEKkATDAEAD
K77-ub KLELAEKkATDAEAD
T79 ELAEKkATDAEADVA
- gap
S87-p DAEADVAsLNRRIQL
T108-p RAQERLAtALQkLEE
K112-ac RLAtALQkLEEAEkA
K112-ub RLAtALQkLEEAEkA
K118-ac QkLEEAEkAADESER
K118-ub QkLEEAEkAADESER
K128-ub DESERGMkVIESRAQ
K136-ub VIESRAQkDEEkMEI
K136-ac VIESRAQkDEEkMEI
K140-ub RAQkDEEkMEIQEIQ
K140-ac RAQkDEEkMEIQEIQ
K149-ac EIQEIQLkEAkHIAE
K149-ub EIQEIQLkEAkHIAE
K152-ub EIQLkEAkHIAEDAD
K152-ac EIQLkEAkHIAEDAD
K161 IAEDADRKyEEVARk
K161-ac IAEDADRkyEEVARk
K161-ub IAEDADRkyEEVARk
Y162-p AEDADRkyEEVARkL
K168-ub kyEEVARkLVIIEsD
S174-p RkLVIIEsDLERAEE
S186-p AEERAELsEGkCAEL
K189-ub RAELsEGkCAELEEE
K198-ub AELEEELktVTNNLk
T199-p ELEEELktVTNNLks
T201 EEELktVTNNLksLE
K205-ub ktVTNNLksLEAQAE
K205-ac ktVTNNLksLEAQAE
S206-p tVTNNLksLEAQAEk
K213-ac sLEAQAEkYsQkEDk
K213-ub sLEAQAEkYsQkEDk
Y214 LEAQAEkYsQkEDky
S215-p EAQAEkYsQkEDkyE
K217-ub QAEkYsQkEDkyEEE
K217-ac QAEkYsQkEDkyEEE
K220-ac kYsQkEDkyEEEIkV
Y221-p YsQkEDkyEEEIkVL
K226-ub DkyEEEIkVLSDkLk
K231-ac EIkVLSDkLkEAETR
K233-ac kVLSDkLkEAETRAE
K233-ub kVLSDkLkEAETRAE
K248-ub FAERSVTkLEksIDD
K248-ac FAERSVTkLEksIDD
K251-ub RSVTkLEksIDDLED
K251-ac RSVTkLEksIDDLED
S252-p SVTkLEksIDDLEDE
Y261-p DDLEDELyAQkLkYk
K264-ac EDELyAQkLkYkAIs
K264-ub EDELyAQkLkYkAIs
K266-ub ELyAQkLkYkAIsEE
K266-ac ELyAQkLkYkAIsEE
Y267 LyAQkLkYkAIsEEL
K268-ub yAQkLkYkAIsEELD
S271-p kLkYkAIsEELDHAL
T282-p DHALNDMtsI_____
S283-p HALNDMtsI______
  TPM1 iso2  
K7 _MDAIKKKMQMLKLD
K12 KKKMQMLKLDKENAL
K15 MQMLKLDKENALDRA
K15 MQMLKLDKENALDRA
K29 AEQAEADKKAAEDRS
K29 AEQAEADKKAAEDRS
K30 EQAEADKKAAEDRSK
K37 KAAEDRSKQLEDELV
S45 QLEDELVSLQKKLKG
K48 DELVSLQKKLKGTED
K48 DELVSLQKKLKGTED
K49 ELVSLQKKLKGTEDE
K49 ELVSLQKKLKGTEDE
T53 LQKKLKGTEDELDKY
K59 GTEDELDKYSEALKD
Y60 TEDELDKYSEALKDA
S61 EDELDKYSEALKDAQ
K65 DKYSEALKDAQEKLE
K77 KLELAEKKATDAEAD
K77 KLELAEKKATDAEAD
T79 ELAEKKATDAEADVA
- gap
S87 DAEADVASLNRRIQL
T108 RAQERLATALQKLEE
K112 RLATALQKLEEAEKA
K112 RLATALQKLEEAEKA
K118 QKLEEAEKAADESER
K118 QKLEEAEKAADESER
K128 DESERGMKVIESRAQ
K136 VIESRAQKDEEKMEI
K136 VIESRAQKDEEKMEI
K140 RAQKDEEKMEIQEIQ
K140 RAQKDEEKMEIQEIQ
K149 EIQEIQLKEAKHIAE
K149 EIQEIQLKEAKHIAE
K152 EIQLKEAKHIAEDAD
K152 EIQLKEAKHIAEDAD
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
Y162 AEDADRKYEEVARKL
K168 KYEEVARKLVIIESD
S174 RKLVIIESDLERAEE
S186 AEERAELSEGKCAEL
K189 RAELSEGKCAELEEE
K198 AELEEELKTVTNNLK
T199 ELEEELKTVTNNLKS
T201 EEELKTVTNNLKSLE
K205 KTVTNNLKSLEAQAE
K205 KTVTNNLKSLEAQAE
S206 TVTNNLKSLEAQAEK
K213 SLEAQAEKYSQKEDK
K213 SLEAQAEKYSQKEDK
Y214 LEAQAEKYSQKEDKY
S215 EAQAEKYSQKEDKYE
K217 QAEKYSQKEDKYEEE
K217 QAEKYSQKEDKYEEE
K220 KYSQKEDKYEEEIKV
Y221 YSQKEDKYEEEIKVL
K226 DKYEEEIKVLSDKLK
K231 EIKVLSDKLKEAETR
K233 KVLSDKLKEAETRAE
K233 KVLSDKLKEAETRAE
K248 FAERSVTKLEKsIDD
K248 FAERSVTKLEKsIDD
K251 RSVTKLEKsIDDLEE
K251 RSVTKLEKsIDDLEE
S252-p SVTKLEKsIDDLEEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TPM1 iso3  
K7 _MDAIKKKMQMLKLD
K12 KKKMQMLKLDKENAL
K15 MQMLKLDKENALDRA
K15 MQMLKLDKENALDRA
K29 AEQAEADKKAAEDRS
K29 AEQAEADKKAAEDRS
K30 EQAEADKKAAEDRSk
K37-ub KAAEDRSkQLEEDIA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S87 KAEADVASLNRRIQL
T108 RAQERLATALQKLEE
K112 RLATALQKLEEAEKA
K112 RLATALQKLEEAEKA
K118 QKLEEAEKAADESER
K118 QKLEEAEKAADESER
K128 DESERGMKVIESRAQ
K136 VIESRAQKDEEKMEI
K136 VIESRAQKDEEKMEI
K140 RAQKDEEKMEIQEIQ
K140 RAQKDEEKMEIQEIQ
K149 EIQEIQLKEAKHIAE
K149 EIQEIQLKEAKHIAE
K152 EIQLKEAKHIAEDAD
K152 EIQLKEAKHIAEDAD
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
Y162 AEDADRKYEEVARKL
K168 KYEEVARKLVIIESD
S174 RKLVIIESDLERAEE
S186 AEERAELSEGKCAEL
K189 RAELSEGKCAELEEE
K198 AELEEELKTVTNNLK
T199 ELEEELKTVTNNLKS
T201 EEELKTVTNNLKSLE
K205 KTVTNNLKSLEAQAE
K205 KTVTNNLKSLEAQAE
S206 TVTNNLKSLEAQAEK
K213 SLEAQAEKYSQKEDK
K213 SLEAQAEKYSQKEDK
Y214 LEAQAEKYSQKEDKY
S215 EAQAEKYSQKEDKYE
K217 QAEKYSQKEDKYEEE
K217 QAEKYSQKEDKYEEE
K220 KYSQKEDKYEEEIKV
Y221 YSQKEDKYEEEIKVL
K226 DKYEEEIKVLSDKLK
K231 EIKVLSDKLKEAETR
K233 KVLSDKLKEAETRAE
K233 KVLSDKLKEAETRAE
K248 FAERSVTKLEKSIDD
K248 FAERSVTKLEKSIDD
K251 RSVTKLEKSIDDLEE
K251 RSVTKLEKSIDDLEE
S252 SVTKLEKSIDDLEEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TPM1 iso4  
K7 _MDAIKKKMQMLKLD
K12 KKKMQMLKLDKENAL
K15 MQMLKLDKENALDRA
K15 MQMLKLDKENALDRA
K29 AEQAEADKKAAEDRS
K29 AEQAEADKKAAEDRS
K30 EQAEADKKAAEDRSK
K37 KAAEDRSKQLEDELV
S45 QLEDELVSLQKKLKG
K48 DELVSLQKKLKGTED
K48 DELVSLQKKLKGTED
K49 ELVSLQKKLKGTEDE
K49 ELVSLQKKLKGTEDE
T53 LQKKLKGTEDELDKY
K59 GTEDELDKYSEALKD
Y60 TEDELDKYSEALKDA
S61 EDELDKYSEALKDAQ
K65 DKYSEALKDAQEKLE
K77 KLELAEKKATDAEAD
K77 KLELAEKKATDAEAD
T79 ELAEKKATDAEADVA
- gap
S87 DAEADVASLNRRIQL
T108 RAQERLATALQKLEE
K112 RLATALQKLEEAEKA
K112 RLATALQKLEEAEKA
K118 QKLEEAEKAADESER
K118 QKLEEAEKAADESER
K128 DESERGMKVIESRAQ
K136 VIESRAQKDEEKMEI
K136 VIESRAQKDEEKMEI
K140 RAQKDEEKMEIQEIQ
K140 RAQKDEEKMEIQEIQ
K149 EIQEIQLKEAKHIAE
K149 EIQEIQLKEAKHIAE
K152 EIQLKEAKHIAEDAD
K152 EIQLKEAKHIAEDAD
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
Y162 AEDADRKYEEVARKL
K168 KYEEVARKLVIIESD
S174 RKLVIIESDLERAEE
S186 AEERAELSEGQVRQL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K213-ac ALMAAEDkYSQKEDK
K213 ALMAAEDKYSQKEDK
Y214 LMAAEDkYSQKEDKY
S215 MAAEDkYSQKEDKYE
K217 AEDkYSQKEDKYEEE
K217 AEDkYSQKEDKYEEE
K220 kYSQKEDKYEEEIKV
Y221 YSQKEDKYEEEIKVL
K226 DKYEEEIKVLSDKLK
K231 EIKVLSDKLKEAETR
K233 KVLSDKLKEAETRAE
K233 KVLSDKLKEAETRAE
K248 FAERSVTKLEKSIDD
K248 FAERSVTKLEKSIDD
K251 RSVTKLEKSIDDLEE
K251 RSVTKLEKSIDDLEE
S252 SVTKLEKSIDDLEEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TPM1 iso10  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K40-ub RELDQERkLRETAEA
S51 TAEADVASLNRRIQL
T72 RAQERLATALQKLEE
K76 RLATALQKLEEAEKA
K76 RLATALQKLEEAEKA
K82 QKLEEAEKAADESER
K82 QKLEEAEKAADESER
K92 DESERGMKVIESRAQ
K100 VIESRAQKDEEKMEI
K100 VIESRAQKDEEKMEI
K104 RAQKDEEKMEIQEIQ
K104 RAQKDEEKMEIQEIQ
K113 EIQEIQLKEAKHIAE
K113 EIQEIQLKEAKHIAE
K116 EIQLKEAKHIAEDAD
K116 EIQLKEAKHIAEDAD
K125 IAEDADRKYEEVARK
K125 IAEDADRKYEEVARK
K125 IAEDADRKYEEVARK
Y126 AEDADRKYEEVARKL
K132 KYEEVARKLVIIESD
S138 RKLVIIESDLERAEE
S150 AEERAELSEGKCAEL
K153 RAELSEGKCAELEEE
K162 AELEEELKTVTNNLK
T163 ELEEELKTVTNNLKS
T165 EEELKTVTNNLKSLE
K169 KTVTNNLKSLEAQAE
K169 KTVTNNLKSLEAQAE
S170 TVTNNLKSLEAQAEK
K177 SLEAQAEKYSQKEDK
K177 SLEAQAEKYSQKEDK
Y178 LEAQAEKYSQKEDKY
S179 EAQAEKYSQKEDKYE
K181 QAEKYSQKEDKYEEE
K181 QAEKYSQKEDKYEEE
K184 KYSQKEDKYEEEIKV
Y185 YSQKEDKYEEEIKVL
K190 DKYEEEIKVLSDKLK
K195 EIKVLSDKLKEAETR
K197 KVLSDKLKEAETRAE
K197 KVLSDKLKEAETRAE
K212 FAERSVTKLEKsIDD
K212 FAERSVTKLEKsIDD
K215 RSVTKLEKsIDDLED
K215 RSVTKLEKsIDDLED
S216-p SVTKLEKsIDDLEDQ
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
K7 _MDAIKKKMQMLkLD
K12-ac KKKMQMLkLDKENAL
K15 MQMLkLDKENALDRA
K15 MQMLkLDKENALDRA
K29 AEQAEADKKAAEDRS
K29 AEQAEADKKAAEDRS
K30 EQAEADKKAAEDRSK
K37 KAAEDRSKQLEDELV
S45-p QLEDELVsLQKKLKG
K48 DELVsLQKKLKGTED
K48 DELVsLQKKLKGTED
K49 ELVsLQKKLKGTEDE
K49 ELVsLQKKLKGTEDE
T53 LQKKLKGTEDELDKy
K59 GTEDELDKysEALKD
Y60-p TEDELDKysEALKDA
S61-p EDELDKysEALKDAQ
K65 DKysEALKDAQEKLE
K77-ac KLELAEKkAtDAEAD
K77 KLELAEKKAtDAEAD
T79-p ELAEKkAtDAEADVA
- gap
S87-p DAEADVAsLNRRIQL
T108-p RAQERLAtALQkLEE
K112-ac RLAtALQkLEEAEkA
K112 RLAtALQKLEEAEkA
K118-ac QkLEEAEkAADESER
K118 QkLEEAEKAADESER
K128 DESERGMKVIESRAQ
K136 VIESRAQKDEEKMEI
K136 VIESRAQKDEEKMEI
K140 RAQKDEEKMEIQEIQ
K140 RAQKDEEKMEIQEIQ
K149 EIQEIQLKEAKHIAE
K149 EIQEIQLKEAKHIAE
K152 EIQLKEAKHIAEDAD
K152 EIQLKEAKHIAEDAD
K161 IAEDADRKyEEVARK
K161-ac IAEDADRkyEEVARK
K161 IAEDADRKyEEVARK
Y162-p AEDADRkyEEVARKL
K168 kyEEVARKLVIIEsD
S174-p RKLVIIEsDLERAEE
S186 AEERAELSEGKCAEL
K189 RAELSEGKCAELEEE
K198 AELEEELKtVtNNLK
T199-p ELEEELKtVtNNLKs
T201-p EEELKtVtNNLKsLE
K205 KtVtNNLKsLEAQAE
K205 KtVtNNLKsLEAQAE
S206-p tVtNNLKsLEAQAEk
K213-ac sLEAQAEkYsQkEDk
K213 sLEAQAEKYsQkEDk
Y214 LEAQAEkYsQkEDkY
S215-p EAQAEkYsQkEDkYE
K217 QAEkYsQKEDkYEEE
K217-ac QAEkYsQkEDkYEEE
K220-ac kYsQkEDkYEEEIKV
Y221 YsQkEDkYEEEIKVL
K226 DkYEEEIKVLSDKLk
K231 EIKVLSDKLkEAETR
K233-ac KVLSDKLkEAETRAE
K233 KVLSDKLKEAETRAE
K248 FAERSVTKLEKsIDD
K248 FAERSVTKLEKsIDD
K251 RSVTKLEKsIDDLED
K251 RSVTKLEKsIDDLED
S252-p SVTKLEKsIDDLEDE
Y261-p DDLEDELyAQkLKyK
K264-ac EDELyAQkLKyKAIS
K264 EDELyAQKLKyKAIS
K266 ELyAQkLKyKAISEE
K266 ELyAQkLKyKAISEE
Y267-p LyAQkLKyKAISEEL
K268 yAQkLKyKAISEELD
S271 kLKyKAISEELDHAL
T282 DHALNDMTsI_____
S283-p HALNDMTsI______
  rabbit

 
K7 _MDAIKKKMQMLKLD
K12 KKKMQMLKLDKENAL
K15 MQMLKLDKENALDRA
K15 MQMLKLDKENALDRA
K29 AEQAEADKKAAEDRS
K29 AEQAEADKKAAEDRS
K30 EQAEADKKAAEDRSK
K37 KAAEDRSKQLEDELV
S45 QLEDELVSLQKKLKG
K48 DELVSLQKKLKGTED
K48 DELVSLQKKLKGTED
K49 ELVSLQKKLKGTEDE
K49 ELVSLQKKLKGTEDE
T53 LQKKLKGTEDELDKY
K59 GTEDELDKYSEALKD
Y60 TEDELDKYSEALKDA
S61 EDELDKYSEALKDAQ
K65 DKYSEALKDAQEKLE
K77 KLELAEKKATDAEAD
K77 KLELAEKKATDAEAD
T79 ELAEKKATDAEADVA
- gap
S87 DAEADVASLNRRIQL
T108 RAQERLATALQKLEE
K112 RLATALQKLEEAEKA
K112 RLATALQKLEEAEKA
K118 QKLEEAEKAADESER
K118 QKLEEAEKAADESER
K128 DESERGMKVIESRAQ
K136 VIESRAQKDEEKMEI
K136 VIESRAQKDEEKMEI
K140 RAQKDEEKMEIQEIQ
K140 RAQKDEEKMEIQEIQ
K149 EIQEIQLKEAKHIAE
K149 EIQEIQLKEAKHIAE
K152 EIQLKEAKHIAEDAD
K152 EIQLKEAKHIAEDAD
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
Y162 AEDADRKYEEVARKL
K168 KYEEVARKLVIIESD
S174 RKLVIIESDLERAEE
S186 AEERAELSEGKCAEL
K189 RAELSEGKCAELEEE
K198 AELEEELKTVTNNLK
T199 ELEEELKTVTNNLKS
T201 EEELKTVTNNLKSLE
K205 KTVTNNLKSLEAQAE
K205 KTVTNNLKSLEAQAE
S206 TVTNNLKSLEAQAEK
K213 SLEAQAEKYSQKEDK
K213 SLEAQAEKYSQKEDK
Y214 LEAQAEKYSQKEDKY
S215 EAQAEKYSQKEDKYE
K217 QAEKYSQKEDKYEEE
K217 QAEKYSQKEDKYEEE
K220 KYSQKEDKYEEEIKV
Y221 YSQKEDKYEEEIKVL
K226 DKYEEEIKVLSDKLK
K231 EIKVLSDKLKEAETR
K233 KVLSDKLKEAETRAE
K233 KVLSDKLKEAETRAE
K248 FAERSVTKLEKSIDD
K248 FAERSVTKLEKSIDD
K251 RSVTKLEKSIDDLED
K251 RSVTKLEKSIDDLED
S252 SVTKLEKSIDDLEDE
Y261 DDLEDELYAQKLKYK
K264 EDELYAQKLKYKAIS
K264 EDELYAQKLKYKAIS
K266 ELYAQKLKYKAISEE
K266 ELYAQKLKYKAISEE
Y267 LYAQKLKYKAISEEL
K268 YAQKLKYKAISEELD
S271 KLKYKAISEELDHAL
T282 DHALNDMTsI_____
S283-p HALNDMTsI______
  pig

 
K7 _MDAIKKKMQMLKLD
K12 KKKMQMLKLDKENAL
K15 MQMLKLDKENALDRA
K15 MQMLKLDKENALDRA
K29 AEQAEADKKAAEDRS
K29 AEQAEADKKAAEDRS
K30 EQAEADKKAAEDRSK
K37 KAAEDRSKRLEDELV
S45 RLEDELVSLQKKLKA
K48 DELVSLQKKLKATED
K48 DELVSLQKKLKATED
K49 ELVSLQKKLKATEDE
K49 ELVSLQKKLKATEDE
T53 LQKKLKATEDELDKY
K59 ATEDELDKYSEAPKD
Y60 TEDELDKYSEAPKDA
S61 EDELDKYSEAPKDAQ
K65 DKYSEAPKDAQEKLE
K77 KLELAEKKATDAEAD
K77 KLELAEKKATDAEAD
T79 ELAEKKATDAEADVA
- gap
S87 DAEADVASLNRRIQL
T108 RAQERLATALQKLEE
K112 RLATALQKLEEAEKA
K112 RLATALQKLEEAEKA
K118 QKLEEAEKAADESER
K118 QKLEEAEKAADESER
K128 DESERGMKVIESRAQ
K136 VIESRAQKDEEKMEI
K136 VIESRAQKDEEKMEI
K140 RAQKDEEKMEIQEIQ
K140 RAQKDEEKMEIQEIQ
K149 EIQEIQLKEAKHIAE
K149 EIQEIQLKEAKHIAE
K152 EIQLKEAKHIAEDAD
K152 EIQLKEAKHIAEDAD
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
K161 IAEDADRKYEEVARK
Y162 AEDADRKYEEVARKL
K168 KYEEVARKLVIIESD
S174 RKLVIIESDLERAEE
S186 AEERAELSEGKCAEL
K189 RAELSEGKCAELEEE
K198 AELEEELKTVTNNLK
T199 ELEEELKTVTNNLKS
T201 EEELKTVTNNLKSLE
K205 KTVTNNLKSLEAQAE
K205 KTVTNNLKSLEAQAE
S206 TVTNNLKSLEAQAEK
K213 SLEAQAEKYSQKEDK
K213 SLEAQAEKYSQKEDK
Y214 LEAQAEKYSQKEDKY
S215 EAQAEKYSQKEDKYE
K217 QAEKYSQKEDKYEEE
K217 QAEKYSQKEDKYEEE
K220 KYSQKEDKYEEEIKV
Y221 YSQKEDKYEEEIKVL
K226 DKYEEEIKVLSDKLK
K231 EIKVLSDKLKEAETR
K233 KVLSDKLKEAETRAE
K233 KVLSDKLKEAETRAE
K248 FAERSVTKLEKSIDD
K248 FAERSVTKLEKSIDD
K251 RSVTKLEKSIDDLED
K251 RSVTKLEKSIDDLED
S252 SVTKLEKSIDDLEDE
Y261 DDLEDELYAQKLKYK
K264 EDELYAQKLKYKAIS
K264 EDELYAQKLKYKAIS
K266 ELYAQKLKYKAISEE
K266 ELYAQKLKYKAISEE
Y267 LYAQKLKYKAISEEL
K268 YAQKLKYKAISEELD
S271 KLKYKAISEELDHAL
T282 DHALNDMTsI_____
S283-p HALNDMTsI______
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