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Protein Page:
Rap1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rap1B GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner. Belongs to the small GTPase superfamily. Ras family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein; G protein, monomeric, Ras
Cellular Component: membrane; plasma membrane; lipid particle; intercellular junction; intracellular; cytosol
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein complex binding
Biological Process: platelet activation; cell proliferation; GTP catabolic process; energy reserve metabolic process; blood coagulation; regulation of insulin secretion; Rap protein signal transduction
Reference #:  P61224 (UniProtKB)
Alt. Names/Synonyms: DKFZp586H0723; GTP-binding protein smg p21B; K-REV; RAL1B; RAP1B; RAP1B, member of RAS oncogene family; Ras family small GTP binding protein RAP1B; Ras-related protein Rap-1b; RAS-related protein RAP1B
Gene Symbols: RAP1B
Molecular weight: 20,825 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rap1B

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S179‑p
protein conformation: S179‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K5-ub ___MREYkLVVLGSG
0 58 K31-ub VQGIFVEkYDPTIED
0 4 S39-p YDPTIEDsYRKQVEV
0 1 T106 QILRVKDTDDVPMIL
0 1 K117 PMILVGNKCDLEDER
0 1 K149 AFLESSAKSKINVNE
0 76 Y159-p INVNEIFyDLVRQIN
5 1 S179-p PGKARKKsscQLL__
2 0 S180-p GKARKKsscQLL___
1 0 C181-me KARKKsscQLL____
  mouse

 
K5-ub ___MREYkLVVLGSG
K31-ub VQGIFVEkYDPTIED
S39-p YDPTIEDsYRKQVEV
T106-p QILRVKDtDDVPMIL
K117-ub PMILVGNkCDLEDER
K149-ub AFLESSAkSKINVNE
Y159-p INVNEIFyDLVRQIN
S179-p PGKARKKsSCQLL__
S180 GKARKKsSCQLL___
C181 KARKKsSCQLL____
  rat

 
K5 ___MREYKLVVLGSG
K31-ub VQGIFVEkYDPTIED
S39 YDPTIEDSYRKQVEV
T106 QILRVKDTDDVPMIL
K117 PMILVGNKCDLEDER
K149 AFLESSAKSKINVNE
Y159-p INVNEIFyDLVRQIN
S179 PGKARKKSSCQLL__
S180 GKARKKSSCQLL___
C181 KARKKSSCQLL____
  cow

 
K5 ___MREYKLVVLGSG
K31 VQGIFVEKYDPTIED
S39 YDPTIEDSYRKQVEV
T106 QILRVKDTDDVPMIL
K117 PMILVGNKCDLEDER
K149 AFLESSAKSKINVNE
Y159 INVNEIFYDLVRQIN
S179-p PGKARKKssCQLL__
S180-p GKARKKssCQLL___
C181 KARKKssCQLL____
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