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Rap1B (human)

Overview Rap1B GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner. Belongs to the small GTPase superfamily. Ras family. Note: This description may include information from UniProtKB. Protein type: G protein; G protein, monomeric (Ras) Cellular Component: membrane; plasma membrane; lipid particle; intracellular; intercellular junction; cytosol Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding Biological Process: platelet activation; cell proliferation; small GTPase mediated signal transduction; energy reserve metabolic process; blood coagulation; regulation of insulin secretion Reference #:  P61224 (UniProtKB) Alt. Names/Synonyms: DKFZp586H0723; GTP-binding protein smg p21B; K-REV; RAL1B; RAP1B; RAP1B, member of RAS oncogene family; Ras family small GTP binding protein RAP1B; Ras-related protein Rap-1b; RAS-related protein RAP1B; small GTP binding protein Gene Symbols: RAP1B Molecular weight: 20,825 Da Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Rap1B 3BRW - D=1-167 (human) 3CF6 - R=1-167 (human) 4DXA - A=1-167 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3BRW 3CF6 4DXA  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
activation: S179‑p protein conformation: S179‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		K5-u	___MREYkLVVLGSG
0	58		K31-u	VQGIFVEkYDPTIED
0	2		S39-p	YDPTIEDsYRKQVEV
0	1		T106	QILRVKDTDDVPMIL
0	1		K117	PMILVGNKCDLEDER
0	1		K149	AFLESSAKSKINVNE
0	68		Y159-p	INVNEIFyDLVRQIN
4	1		S179-p	PGKARKKsscQLL__
1	0		S180-p	GKARKKsscQLL___
1	0		C181-m	KARKKsscQLL____

	mouse
K5-u	___MREYkLVVLGSG
K31-u	VQGIFVEkYDPTIED
S39-p	YDPTIEDsYRKQVEV
T106-p	QILRVKDtDDVPMIL
K117-u	PMILVGNkCDLEDER
K149-u	AFLESSAkSKINVNE
Y159-p	INVNEIFyDLVRQIN
S179-p	PGKARKKsSCQLL__
S180	GKARKKsSCQLL___
C181	KARKKsSCQLL____

	rat
K5	___MREYKLVVLGSG
K31-u	VQGIFVEkYDPTIED
S39	YDPTIEDSYRKQVEV
T106	QILRVKDTDDVPMIL
K117	PMILVGNKCDLEDER
K149	AFLESSAKSKINVNE
Y159-p	INVNEIFyDLVRQIN
S179	PGKARKKSSCQLL__
S180	GKARKKSSCQLL___
C181	KARKKSSCQLL____

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