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REPS1 (human)

Overview REPS1 a vesicle-associated protein that influences endocytosis through its ability to interact with Rab11FIP2 and RALBP1. An EGFR substrate that interacts with CRK and GRB2. May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Vesicle protein Cellular Component: plasma membrane; coated pit Molecular Function: protein binding; calcium ion binding; SH3 domain binding Biological Process: receptor-mediated endocytosis Reference #:  Q96D71 (UniProtKB) Alt. Names/Synonyms: RALBP1; RALBP1 associated Eps domain containing 1; RalBP1-associated Eps domain-containing protein 1; RalBP1-interacting protein 1; REPS1 Gene Symbols: REPS1 Molecular weight: 86,662 Da Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below REPS1 1FI6 - A=227-318 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		S115-p	QESRHAAsyssDsEN
0	26		Y116-p	ESRHAAsyssDsENQ
0	2		S117-p	SRHAAsyssDsENQG
0	13		S118-p	RHAAsyssDsENQGs
0	4		S120-p	AAsyssDsENQGsys
0	7		S125-p	sDsENQGsysGVIPP
0	60		Y126-p	DsENQGsysGVIPPP
0	1		S127-p	sENQGsysGVIPPPP
0	48		S143-p	RGQVKKGsVsHDtVQ
0	7		S145-p	QVKKGsVsHDtVQPR
0	1		T148-p	KGsVsHDtVQPRTSA
0	19		S162-p	ADAQEPAsPVVsPQQ
0	7		S166-p	EPAsPVVsPQQsPPt
0	23		S170-p	PVVsPQQsPPtsPHt
0	14		T173-p	sPQQsPPtsPHtWRK
0	8		S174-p	PQQsPPtsPHtWRKH
0	1		T177-p	sPPtsPHtWRKHSRH
0	20		S186-p	RKHSRHPsGGNSERP
0	1		T258	QDQTTVRTVAsAttA
0	1		S261-p	TTVRTVAsAttAIEI
0	1		T263-p	VRTVAsAttAIEIRR
0	1		T264-p	RTVAsAttAIEIRRQ
0	420		S272-p	AIEIRRQsssyDDPW
0	265		S273-p	IEIRRQsssyDDPWK
0	46		S274-p	EIRRQsssyDDPWKI
0	39		Y275-p	IRRQsssyDDPWKIT
0	2		S307-p	LNGFIPGsAAKEFFT
0	1		S390	QPGEVGYSGsPAEAP
0	2		S392-p	GEVGYSGsPAEAPPs
0	1		S399-p	sPAEAPPsKSPSMPS
0	2		S401	AEAPPsKSPSMPSLN
0	1		S406	sKSPSMPSLNQTWPE
0	1		S428	WETFSERSssSQTLT
0	1		S429-p	ETFSERSssSQTLTQ
0	1		S430-p	TFSERSssSQTLTQF
0	2		T459-p	HPVPIRMtPskIHMQ
0	1		S461-p	VPIRMtPskIHMQEM
0	1		K462	PIRMtPsKIHMQEME
0	1		K462-u	PIRMtPskIHMQEME
0	1		T473-p	QEMELKRtGSDHTNP
0	4		T481-p	GSDHTNPtsPLLVKP
0	9		S482-p	SDHTNPtsPLLVKPs
0	1		S489-p	sPLLVKPsDLLEENK
0	1		D511-ca	ASGNTVAdGYSsSdS
0	1		S515-p	TVAdGYSsSdSFTSD
0	1		D517-ca	AdGYSsSdSFTSDPE
0	14		S535-p	SNVTRQRsHsGtsPD
0	21		S537-p	VTRQRsHsGtsPDNt
0	11		T539-p	RQRsHsGtsPDNtAP
0	15		S540-p	QRsHsGtsPDNtAPP
0	6		T544-p	sGtsPDNtAPPPPPP
0	2		S556-p	PPPRPQPsHsRsssL
0	6		S558-p	PRPQPsHsRsssLDM
0	1		S560-p	PQPsHsRsssLDMNR
0	2		S561-p	QPsHsRsssLDMNRT
0	32		S562-p	PsHsRsssLDMNRTF
0	2		S667-p	KASDPASsLRVAKTD
0	2		T694-p	ANVSKGTtPLAPPPK
0	505		S709-p	PVRRRLKsEDELRPE
0	1		T721	RPEVDEHTQKTGVLA
0	12		S736-p	AVLASQPsIPRsVGK
0	1		S740-p	SQPsIPRsVGKDKKA
0	1		S751-p	DKKAIQAsIRRNKEt
0	1		T758-p	sIRRNKEtNTVLARL
0	10		S767-p	TVLARLNsELQQQLK

	mouse ► Hide Isoforms
S115	QESRLAASYSsDSEN
Y116	ESRLAASYSsDSENQ
S117	SRLAASYSsDSENQG
S118-p	RLAASYSsDSENQGS
S120	AASYSsDSENQGSYS
S125	sDSENQGSYSGVIPP
Y126	DSENQGSYSGVIPPP
S127	SENQGSYSGVIPPPP
P143	RGQVKKGPGsHDAVQ
S145-p	QVKKGPGsHDAVQPR
A148	KGPGsHDAVQPRPSA
S162-p	AEQQEPVsPVVsPQQ
S166-p	EPVsPVVsPQQsPPT
S170-p	PVVsPQQsPPTSPHT
T173	sPQQsPPTSPHTWRK
S174	PQQsPPTSPHTWRKH
T177	sPPTSPHTWRKHSRH
S186-p	RKHSRHPsGGNSERP
T258-g	QDQTTVRtVASAATA
S261	TTVRtVASAATANEI
A263	VRtVASAATANEIRR
T264	RtVASAATANEIRRQ
S272-p	ANEIRRQsssyEDPW
S273-p	NEIRRQsssyEDPWK
S274-p	EIRRQsssyEDPWKI
Y275-p	IRRQsssyEDPWKIT
S307	LNGFIPGSAAKEFFT
S390-p	QPGEVGYsGsPAEAP
S392-p	GEVGYsGsPAEAPPS
S399	sPAEAPPSKSPSMPS
S401	AEAPPSKSPSMPSLN
S406	SKSPSMPSLNQTWPE
S428-p	WETFSERssSSQTLT
S429-p	ETFSERssSSQTLTQ
S430	TFSERssSSQTLTQF
T459	HPVPIRMTPSkIHMQ
S461	VPIRMTPSkIHMQEM
K462-a	PIRMTPSkIHMQEME
K462	PIRMTPSKIHMQEME
T473-p	QEMELKRtSSDHTNP
T481-p	SSDHTNPtsPLLVKP
S482-p	SDHTNPtsPLLVKPS
S489	sPLLVKPSDLSEENK
D510	FPSGNTVDGYSSSDS
S514	NTVDGYSSSDSFPSD
D516	VDGYSSSDSFPSDPE
S534-p	SSVTRQRsHsGtsPD
S536-p	VTRQRsHsGtsPDNt
T538-p	RQRsHsGtsPDNtAP
S539-p	QRsHsGtsPDNtAPP
T543-p	sGtsPDNtAPPPPPP
S555-p	PPPRPQPsHsRSSsL
S557-p	PRPQPsHsRSSsLDM
S559	PQPsHsRSSsLDMNR
S560	QPsHsRSSsLDMNRT
S561-p	PsHsRSSsLDMNRTF
S666	KASDPSSSLRAAQAD
T693	ANVSKGTTPLAPPPK
S708-p	PVRRRLKsEDELRPD
T720-p	RPDVDEHtQKTGVLA
S735-p	AVLTSQPsIPRSVGK
S739	SQPsIPRSVGKDKKA
S750	DKKAIQASIRRNKET
T757	SIRRNKETNTVLARL
S766-p	TVLARLNsELQQQLK

	REPS1 iso3
S63	QESRLAASYSSDSEN
Y64	ESRLAASYSSDSENQ
S65	SRLAASYSSDSENQG
S66	RLAASYSSDSENQGS
S68	AASYSSDSENQGSYS
S73	SDSENQGSYSGVIPP
Y74	DSENQGSYSGVIPPP
S75	SENQGSYSGVIPPPP
P91	RGQVKKGPGSHDAVQ
S93	QVKKGPGSHDAVQPR
A96	KGPGSHDAVQPRPSA
S110	AEQQEPVSPVVSPQQ
S114	EPVSPVVSPQQSPPT
S118	PVVSPQQSPPTSPHT
T121	SPQQSPPTSPHTWRK
S122	PQQSPPTSPHTWRKH
T125	SPPTSPHTWRKHSRH
S134	RKHSRHPSGGNSERP
T206	QDQTTVRTVASAATA
S209	TTVRTVASAATANEI
A211	VRTVASAATANEIRR
T212	RTVASAATANEIRRQ
S220	ANEIRRQSSSYEDPW
S221	NEIRRQSSSYEDPWK
S222	EIRRQSSSYEDPWKI
Y223	IRRQSSSYEDPWKIT
S255	LNGFIPGSAAKEFFT
S338	QPGEVGYSGSPAEAP
S340	GEVGYSGSPAEAPPS
S347	SPAEAPPSKsPSMPs
S349-p	AEAPPSKsPSMPsLN
S354-p	SKsPSMPsLNQTWPE
-	gap
-	gap
-	gap
T380	HPVPIRMTPSKIHMQ
S382	VPIRMTPSKIHMQEM
K383	PIRMTPSKIHMQEME
K383	PIRMTPSKIHMQEME
T394	QEMELKRTSSDHTNP
T402	SSDHTNPTSPLLVKP
S403	SDHTNPTSPLLVKPS
S410	SPLLVKPSDLSEENK
D431	FPSGNTVDGYSSSDS
S435	NTVDGYSSSDSFPSD
D437	VDGYSSSDSFPSDPE
S455	SSVTRQRSHSGTSPD
S457	VTRQRSHSGTSPDNT
T459	RQRSHSGTSPDNTAP
S460	QRSHSGTSPDNTAPP
T464	SGTSPDNTAPPPPPP
S476	PPPRPQPSHSRSSSL
S478	PRPQPSHSRSSSLDM
S480	PQPSHSRSSSLDMNR
S481	QPSHSRSSSLDMNRT
S482	PSHSRSSSLDMNRTF
S587	KASDPSSSLRAAQAD
T614	ANVSKGTTPLAPPPK
S629	PVRRRLKSEDELRPD
T641	RPDVDEHTQKTGVLA
S656	AVLTSQPSIPRSVGK
S660	SQPSIPRSVGKDKKA
S671	DKKAIQASIRRNKET
T678	SIRRNKETNTVLARL
S687	TVLARLNSELQQQLK

	rat
S115	QESRHAASYSSDAEN
Y116	ESRHAASYSSDAENQ
S117	SRHAASYSSDAENQS
S118	RHAASYSSDAENQSA
A120	AASYSSDAENQSAYA
A125	SDAENQSAYAGVIPP
Y126	DAENQSAYAGVIPPP
A127	AENQSAYAGVIPPPP
P143	RGQVKKAPGSHDAAQ
S145	QVKKAPGSHDAAQPR
A148	KAPGSHDAAQPRPSA
S162	ADQQEPASPVVSPQQ
S166	EPASPVVSPQQSPPT
S170	PVVSPQQSPPTSPHT
T173	SPQQSPPTSPHTWRK
S174	PQQSPPTSPHTWRKH
T177	SPPTSPHTWRKHNRH
S186	RKHNRHPSGGNSERP
T258	QDQTTVRTVASATTA
S261	TTVRTVASATTANEI
T263	VRTVASATTANEIRR
T264	RTVASATTANEIRRQ
S272-p	ANEIRRQssSyDDPW
S273-p	NEIRRQssSyDDPWK
S274	EIRRQssSyDDPWKI
Y275-p	IRRQssSyDDPWKIT
S307	LNGFIPGSAAKEFFT
P390	QPGEVGYPGSPAEAP
S392	GEVGYPGSPAEAPPS
S399	SPAEAPPSKSPSMPS
S401	AEAPPSKSPSMPSLN
S406	SKSPSMPSLNQTWPE
S428	WETFSERSSSSQTLT
S429	ETFSERSSSSQTLTQ
S430	TFSERSSSSQTLTQF
T459	HPVPIRMTPSKIHMQ
S461	VPIRMTPSKIHMQEM
K462	PIRMTPSKIHMQEME
K462	PIRMTPSKIHMQEME
S473	QEMELKRSSGDHTNP
T481	SGDHTNPTSPLLVKP
S482	GDHTNPTSPLLVKPS
S489	SPLLVKPSDLSEENK
D511	PSGNTVADGYSSSDS
S515	TVADGYSSSDSFPSD
D517	ADGYSSSDSFPSDPE
S535	SNGARQRSHSGASPD
S537	GARQRSHSGASPDNT
A539	RQRSHSGASPDNTAP
S540	QRSHSGASPDNTAPP
T544	SGASPDNTAPPPPPP
S556	PPPRPQPSHSRSSSL
S558	PRPQPSHSRSSSLDM
S560	PQPSHSRSSSLDMNR
S561	QPSHSRSSSLDMNRT
S562	PSHSRSSSLDMNRTF
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

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