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Protein Page:
TLK1 iso1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TLK1 iso1 a protein kinase of the TLK family. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation, possibly by CHK1. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; TLK family
Cellular Component: nucleus
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: intracellular protein transport; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; protein amino acid phosphorylation; response to DNA damage stimulus
Reference #:  Q9UKI8 (UniProtKB)
Alt. Names/Synonyms: KIAA0137; PKU-beta; serine threonine protein kinase; Serine/threonine-protein kinase tousled-like 1; SNARE protein kinase SNAK; TLK1; Tousled-like kinase 1
Gene Symbols: TLK1
Molecular weight: 86,700 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below

TLK1 iso1

Protein Structure Not Found.


Scansite  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S20 PPSWSQLSTsPTPGS
0 1 T21 PSWSQLSTsPTPGSA
0 5 S22-p SWSQLSTsPTPGSAA
0 1 T24 SQLSTsPTPGSAAAA
0 1 S33-p GSAAAARsLLNHtPP
0 3 T38-p ARsLLNHtPPSGRPR
0 1 S54-p GAMDELHsLDPRRQE
0 1 T68 ELLEARFTGVASGsT
0 1 S74-p FTGVASGsTGstGsC
0 1 S77-p VASGsTGstGsCSVG
0 1 T78-p ASGsTGstGsCSVGA
0 1 S80-p GsTGstGsCSVGAKA
0 1 S82 TGstGsCSVGAKAST
0 3 S93-p KASTNNEsSNHsFGS
0 2 S97-p NNEsSNHsFGSLGsL
0 4 S103-p HsFGSLGsLsDKESE
0 3 S105-p FGSLGsLsDKESETP
0 3 S159 GRTAGGKSIGGRGHK
0 1 S179-p EYQGGNGssPVRGIP
0 18 S180-p YQGGNGssPVRGIPP
0 6 S209-p SSSVRPNsPSPTALA
0 1 K721 TEVQFPVKPVVSSEA
0 2 Y738-p FIRRCLAyRKEDRFD
0 5 S762-p LLPHMRRsNsSGNLH
2 0 S764-p PHMRRsNsSGNLHMA
4121 : Phospho-TLK1 (Ser695) Antibody
  TLK1 iso1  
S20 PPSWSQLSTSPTPGS
T21 PSWSQLSTSPTPGSA
S22 SWSQLSTSPTPGSAA
T24 SQLSTSPTPGSAAAA
S33 GSAAAARSLLNHTPP
T38 ARSLLNHTPPSGRPR
S54 GAMDELHSLDPRRQE
T68 ELLEARFTGVASGST
S74 FTGVASGSTGSTGSC
S77 VASGSTGSTGSCSVG
T78 ASGSTGSTGSCSVGA
S80 GSTGSTGSCSVGAKA
S82 TGSTGSCSVGAKAST
S93 KASTNNESSNHSFGS
S97 NNESSNHSFGSLGSL
S103 HSFGSLGSLSDKESE
S105 FGSLGSLSDKESETP
S138-p NESSQGKsIGGRGHK
S158 EYQGGNGSSPVRGIP
S159 YQGGNGSSPVRGIPP
S188 SSSVRPNSPSPTALA
K700 TEVQFPVKPVVSSEA
Y717 FIRRCLAYRKEDRFD
S741 LLPHMRRSNSSGNLH
S743 PHMRRSNSSGNLHMA
  mouse

 
S20-p PPSWSRLstsPtPGS
T21-p PSWSRLstsPtPGSA
S22-p SWSRLstsPtPGSAA
T24-p SRLstsPtPGSAAAA
S33 GSAAAARSLLNHtPP
T38-p ARSLLNHtPPSGRPR
S54 GAMDELHSLDPRRQE
T68-p ELLEARFtGVATGsT
S74-p FtGVATGsTGstGsC
S77-p VATGsTGstGsCsVG
T78-p ATGsTGstGsCsVGA
S80-p GsTGstGsCsVGAKA
S82-p TGstGsCsVGAKAST
S93 KASTNNESSNHSFGS
S97 NNESSNHSFGSLGSL
S103 HSFGSLGSLSDKESE
S105 FGSLGSLSDKESETP
S138 NESSQGKSIGGRGHK
S158-p EYQGGNGssPVRGIP
S159-p YQGGNGssPVRGIPP
S188 SSSVRPNSPSPTALA
K700-u TEVQFPVkPVVSSEA
Y717 FIRRCLAYRKEDRFD
S741-p LLPHMRRsNsSGNLH
S743-p PHMRRsNsSGNLHMS
4121 : Phospho-TLK1 (Ser695) Antibody
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