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TLK1 iso1 (human)

Overview TLK1 iso1 a protein kinase of the TLK family. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation, possibly by CHK1. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; TLK family Cellular Component: nucleus Molecular Function: protein serine/threonine kinase activity; ATP binding Biological Process: intracellular protein transport; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; protein amino acid phosphorylation; response to DNA damage stimulus Reference #:  Q9UKI8 (UniProtKB) Alt. Names/Synonyms: KIAA0137; PKU-beta; serine threonine protein kinase; Serine/threonine-protein kinase tousled-like 1; SNARE protein kinase SNAK; TLK1; Tousled-like kinase 1 Gene Symbols: TLK1 Molecular weight: 86,700 Da Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states

Select Structure to View Below TLK1 iso1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	3		S20	PPSWSQLSTsPTPGS
0	1		T21	PSWSQLSTsPTPGSA
0	5		S22-p	SWSQLSTsPTPGSAA
0	1		T24	SQLSTsPTPGSAAAA
0	1		S33-p	GSAAAARsLLNHtPP
0	2		T38-p	ARsLLNHtPPSGRPR
0	1		T68	ELLEARFTGVASGsT
0	1		S74-p	FTGVASGsTGStGSC
0	1		T78-p	ASGsTGStGSCSVGA
0	1		S80	GsTGStGSCSVGAKA
0	1		S82	TGStGSCSVGAKASt
0	1		T89-p	SVGAKAStNNEssNH
0	3		S93-p	KAStNNEssNHsFGs
0	1		S94-p	AStNNEssNHsFGsL
0	2		S97-p	NNEssNHsFGsLGsL
0	1		S100-p	ssNHsFGsLGsLsDK
0	4		S103-p	HsFGsLGsLsDKESE
0	3		S105-p	FGsLGsLsDKESETP
0	1		S133	KAENQNESSQGFPNL
0	3		S159	GRTAGGKSIGGRGHK
0	1		S179	EYQGGNGSsPVRGIP
0	17		S180-p	YQGGNGSsPVRGIPP
0	1		S191-p	GIPPAIRsPQNSHsH
0	1		S197-p	RsPQNSHsHSTPSSS
0	1		S202	SHsHSTPSSSVRPNs
0	6		S209-p	SSSVRPNsPSPtALA
0	1		T213-p	RPNsPSPtALAFGDH
0	1		K255-a	NKIQDLEkKEGRIDD
0	1		K290	KYKERLNKCISMSKK
0	1		T334-p	VRHGASFtEQWTDGF
0	1		S584-p	MSEKEARsIVMQIVN
0	1		K721	TEVQFPVKPVVSSEA
0	2		Y738-p	FIRRCLAyRKEDRFD
0	4		S762-p	LLPHMRRsNsSGNLH
2	0		S764-p	PHMRRsNsSGNLHMA

	TLK1 iso1
S20	PPSWSQLSTSPTPGS
T21	PSWSQLSTSPTPGSA
S22	SWSQLSTSPTPGSAA
T24	SQLSTSPTPGSAAAA
S33	GSAAAARSLLNHTPP
T38	ARSLLNHTPPSGRPR
T68	ELLEARFTGVASGST
S74	FTGVASGSTGSTGSC
T78	ASGSTGSTGSCSVGA
S80	GSTGSTGSCSVGAKA
S82	TGSTGSCSVGAKAST
T89	SVGAKASTNNESSNH
S93	KASTNNESSNHSFGS
S94	ASTNNESSNHSFGSL
S97	NNESSNHSFGSLGSL
S100	SSNHSFGSLGSLSDK
S103	HSFGSLGSLSDKESE
S105	FGSLGSLSDKESETP
S133-p	KAENQNEsSQGKsIG
S138-p	NEsSQGKsIGGRGHK
S158	EYQGGNGSSPVRGIP
S159	YQGGNGSSPVRGIPP
S170	GIPPAIRSPQNSHSH
S176	RSPQNSHSHSTPSSS
S181	SHSHSTPSSSVRPNS
S188	SSSVRPNSPSPTALA
T192	RPNSPSPTALAFGDH
K234	NKIQDLEKKEGRIDD
K269	KYKERLNKCISMSKK
T313	VRHGASFTEQWTDGF
S563	MSEKEARSIVMQIVN
K700	TEVQFPVKPVVSSEA
Y717	FIRRCLAYRKEDRFD
S741	LLPHMRRSNSSGNLH
S743	PHMRRSNSSGNLHMA

	mouse
S20-p	PPSWSRLstsPtPGS
T21-p	PSWSRLstsPtPGSA
S22-p	SWSRLstsPtPGSAA
T24-p	SRLstsPtPGSAAAA
S33	GSAAAARSLLNHtPP
T38-p	ARSLLNHtPPSGRPR
T68-p	ELLEARFtGVATGsT
S74-p	FtGVATGsTGStGsC
T78-p	ATGsTGStGsCsVGA
S80-p	GsTGStGsCsVGAKA
S82-p	TGStGsCsVGAKAST
T89	sVGAKASTNNESSNH
S93	KASTNNESSNHSFGS
S94	ASTNNESSNHSFGSL
S97	NNESSNHSFGSLGSL
S100	SSNHSFGSLGSLSDK
S103	HSFGSLGSLSDKESE
S105	FGSLGSLSDKESETP
S133	KAESQNESSQGKSIG
S138	NESSQGKSIGGRGHK
S158-p	EYQGGNGssPVRGIP
S159-p	YQGGNGssPVRGIPP
S170	GIPPAIRSPQNSHSH
S176	RSPQNSHSHSTPsSS
S181-p	SHSHSTPsSSVRPNS
S188	sSSVRPNSPSPTALA
T192	RPNSPSPTALAFGDH
K234	TKNQDLEKKEGRIDD
K269-a	KYKERLNkCISMSKK
T313	VRHGASFTEQWTDGF
S563	MSEKEARSIVMQIVN
K700-u	TEVQFPVkPVVSSEA
Y717	FIRRCLAYRKEDRFD
S741-p	LLPHMRRsNsSGNLH
S743-p	PHMRRsNsSGNLHMS

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