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Protein Page:
BAG3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BAG3 Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. Defects in BAG3 are the cause of myopathy myofibrillar type 6 (MFM6). A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. Defects in BAG3 are the cause of cardiomyopathy dilated type 1HH (CMD1HH). CMD1HH is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Cellular Component: neuron projection; cytosol; Z disc
Molecular Function: protein binding; chaperone binding; protein complex binding
Biological Process: protein stabilization; protein folding; induction of apoptosis via death domain receptors; spinal cord development; brain development; negative regulation of apoptosis
Reference #:  O95817 (UniProtKB)
Alt. Names/Synonyms: BAG family molecular chaperone regulator 3; BAG-3; BAG-family molecular chaperone regulator-3; BAG3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; BCL2-associated athanogene 3; BCL2-binding athanogene 3; BIS; CAIR-1; Docking protein CAIR-1; MGC104307
Gene Symbols: BAG3
Molecular weight: 61,595 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
Select Structure to View Below

BAG3

Protein Structure Not Found.


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Sites Implicated In
cell motility, induced: S187‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 11 Y86-p AREGHPVyPQLRPGy
0 43 Y93-p yPQLRPGyIPIPVLH
0 9 Y114-p QVHPFHVyPQPGMQr
0 3 P115 VHPFHVyPQPGMQrF
0 1 R121-m2 yPQPGMQrFRTEAAA
0 1 R121-m1 yPQPGMQrFRTEAAA
0 6 S134-p AAAAPQRsQsPLRGM
0 10 S136-p AAPQRsQsPLRGMPE
0 2 R139 QRsQsPLRGMPETTQ
0 8 S171-p ASHGPERsQsPAAsD
0 12 S173-p HGPERsQsPAAsDCs
0 2 S177-p RsQsPAAsDCsSSSS
0 1 S180-p sPAAsDCsSSSSSAs
1 0 S187-p sSSSSSAsLPSSGRs
0 4 S194-p sLPSSGRssLGsHQL
0 4 S195-p LPSSGRssLGsHQLP
0 1 S198-p SGRssLGsHQLPRGy
0 14 Y205-p sHQLPRGyIsIPVIH
0 2 S207-p QLPRGyIsIPVIHEQ
0 3 Y233-p HQAQKTHyPAQQGEy
0 187 Y240-p yPAQQGEyQtHQPVy
0 27 T242-p AQQGEyQtHQPVyHK
0 257 Y247-p yQtHQPVyHKIQGDD
0 1 K249 tHQPVyHKIQGDDWE
0 1 R261-m1 DWEPRPLrAAsPFRs
0 25 S264-p PRPLrAAsPFRssVQ
0 17 S268-p rAAsPFRssVQGAss
0 3 S269-p AAsPFRssVQGAssR
0 1 Q271 sPFRssVQGAssREG
0 4 S274-p RssVQGAssREGsPA
0 16 S275-p ssVQGAssREGsPAR
0 22 S279-p GAssREGsPARsstP
0 6 S283-p REGsPARsstPLHsP
0 22 S284-p EGsPARsstPLHsPs
0 54 T285-p GsPARsstPLHsPsP
0 53 S289-p RsstPLHsPsPIRVH
0 29 S291-p stPLHsPsPIRVHTV
0 1 S348 VIRKEVDSKPVSQKP
0 1 S352 EVDSKPVSQKPPPPS
0 3 P355 SKPVSQKPPPPSEKV
0 3 P375 PAPVPCPPPsPGPsA
0 30 S377-p PVPCPPPsPGPsAVP
0 2 S381-p PPPsPGPsAVPssPK
0 13 S385-p PGPsAVPssPKSVAt
0 12 S386-p GPsAVPssPKSVAtE
0 2 T392-p ssPKSVAtEERAAPs
0 3 S399-p tEERAAPsTAPAEAt
0 8 T406-p sTAPAEAtPPKPGEA
0 1 K445 AVDNFEGKKTDKkyL
0 3 K450-u EGKKTDKkyLMIEEy
0 2 Y451-p GKKTDKkyLMIEEyL
0 52 Y457-p kyLMIEEyLTKELLA
0 10 Y508-p VPGQVQVyELQPSNL
  mouse

 
Y88 IREGHPIYPQLRPGY
Y95 YPQLRPGYIPIPVLH
Y116-p QPHLFHAysQPGVQr
S117-p PHLFHAysQPGVQrF
R123-m2 ysQPGVQrFRTEAAA
R123 ysQPGVQRFRTEAAA
S136-p AAATPQRsQsPLrGG
S138-p ATPQRsQsPLrGGMT
R141-m1 QRsQsPLrGGMTEAA
S177-p TAHGPERsQsPAAsD
S179-p HGPERsQsPAAsDCs
S183-p RsQsPAAsDCsSSSS
S186-p sPAAsDCsSSSSSAS
S193 sSSSSSASLPSSGRs
S200-p SLPSSGRssLGSHQL
S201-p LPSSGRssLGSHQLP
S204 SGRssLGSHQLPRGY
Y211 SHQLPRGYIPIPVIH
P213 QLPRGYIPIPVIHEQ
Y239 HQAQKTHYPAQQGEy
Y246-p YPAQQGEyQPQQPVy
P248 AQQGEyQPQQPVyHk
Y253-p yQPQQPVyHkIQGDD
K255-u PQQPVyHkIQGDDWE
R267-m1 DWEPRPLrAAsPFRs
S270-p PRPLrAAsPFRsPVr
S274-p rAAsPFRsPVrGAss
P275 AAsPFRsPVrGAssR
R277-m1 sPFRsPVrGAssREG
S280-p RsPVrGAssREGsPA
S281-p sPVrGAssREGsPAR
S285-p GAssREGsPARsGtP
S289-p REGsPARsGtPVHCP
G290 EGsPARsGtPVHCPs
T291-p GsPARsGtPVHCPsP
C295 RsGtPVHCPsPIRVH
S297-p GtPVHCPsPIRVHTV
S353-p VIRREADsKPVsQKs
S357-p EADsKPVsQKsPPPA
S360-p sKPVsQKsPPPAEKV
S380-p SAPIPCPsPsPAPsA
S382-p PIPCPsPsPAPsAVP
S386-p PsPsPAPsAVPsPPK
S390-p PAPsAVPsPPKNVAA
P391 APsAVPsPPKNVAAE
A397 sPPKNVAAEQKAAPs
S404-p AEQKAAPsPAPAEPA
A411 sPAPAEPAAPKSGEA
K450-u AVDSFEGkKTDKkyL
K455-u EGkKTDKkyLMIEEy
Y456-p GkKTDKkyLMIEEyL
Y462-p kyLMIEEyLTKELLA
Y513 VPGQVQVYELQPSNL
  rat

 
Y88 AREGHPIYPQLRPGY
Y95 YPQLRPGYIPIPVHH
Y116 QPHLFHAYSQPGVQR
S117 PHLFHAYSQPGVQRF
R123 YSQPGVQRFRTEAAA
R123 YSQPGVQRFRTEAAA
S136 AAAAPQRSQSPLRGG
S138 AAPQRSQSPLRGGVT
R141 QRSQSPLRGGVTETT
S174-p TAHGPERsQsPAASD
S176-p HGPERsQsPAASDCS
S180 RsQsPAASDCSSSSS
S183 sPAASDCSSSSSSAS
S190 SSSSSSASLGSSGRS
S197 SLGSSGRSSLGSHQL
S198 LGSSGRSSLGSHQLP
S201 SGRSSLGSHQLPRGY
Y208 SHQLPRGYIPIPVIH
P210 QLPRGYIPIPVIHEQ
Y236 HQAQKTHYPAQQGEy
Y243-p YPAQQGEyQPQQPVy
P245 AQQGEyQPQQPVyHK
Y250-p yQPQQPVyHKIQGDD
K252 PQQPVyHKIQGDDWE
R264 DWEPRPLRATSPFRS
S267 PRPLRATSPFRSPVR
S271 RATSPFRSPVRGASS
P272 ATSPFRSPVRGASSR
R274 SPFRSPVRGASSREG
S277 RSPVRGASSREGSPA
S278 SPVRGASSREGSPAR
S282 GASSREGSPARSGTP
S286 REGSPARSGTPVHCP
G287 EGSPARSGTPVHCPs
T288 GSPARSGTPVHCPsP
C292 RSGTPVHCPsPIRVH
S294-p GTPVHCPsPIRVHTV
S350 VIRREADSKPVFQKP
F354 EADSKPVFQKPPPPA
P357 SKPVFQKPPPPAEKV
S377 SAPIPCPSPGPAPSA
G379 PIPCPSPGPAPSAVP
S383 PSPGPAPSAVPSSPK
S387 PAPSAVPSSPKNVAA
S388 APSAVPSSPKNVAAE
A394 SSPKNVAAEPKAAPs
S401-p AEPKAAPsPAPAEAA
A408 sPAPAEAAPLKSGDS
K447 AVDNFEGKKTDKKYL
K452 EGKKTDKKYLMIEEY
Y453 GKKTDKKYLMIEEYL
Y459 KYLMIEEYLTKELLA
Y510 VPGQVQVYELQPSNL
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