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hnRNP R (human)

Overview hnRNP R Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: RNA splicing; RNA binding protein Cellular Component: nucleoplasm; cytoplasm; nucleolus; ribonucleoprotein complex; nucleus Molecular Function: protein binding; RNA binding; nucleotide binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA processing Reference #:  O43390 (UniProtKB) Alt. Names/Synonyms: FLJ25714; Heterogeneous nuclear ribonucleoprotein R; hnRNP R; hnRNP-R; HNRNPR; HNRPR Gene Symbols: HNRNPR Molecular weight: 70,943 Da Basal Isoelectric point: 8.23  Predict pI for various phosphorylation states

Select Structure to View Below hnRNP R 2DK2 - A=333-416 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K41-u	IEAGLPQkVAERLDE
0	7		K103-a	AFLCGVMkTYRQREK
0	2		K103-u	AFLCGVMkTYRQREK
0	1		K126-m3	TKGPDEAkIkALLER
0	1		K128-m3	GPDEAkIkALLERTG
0	2		K171-u	GTEVFVGkIPRDLYE
0	21		K187-u	ELVPLFEkAGPIWDL
0	2		Y208-p	LSGQNRGyAFITFCG
0	1		K224-u	EAAQEAVkLCDSyEI
0	2		Y229-p	AVkLCDSyEIRPGKH
0	3		S252-p	NNRLFVGsIPKNKTk
0	1		K259-m1	sIPKNKTkENILEEF
0	1		K313-u	RRRLMSGkVKVWGNV
0	6		K341-u	PEVMAKVkVLFVRNL
0	10		K359-u	VTEEILEkSFSEFGk
0	2		K366-a	kSFSEFGkLERVKKL
0	37		K366-u	kSFSEFGkLERVKKL
0	1		K374-u	LERVKKLkDyAFVHF
0	1		Y376-p	RVKKLkDyAFVHFED
0	1		K389-a	EDRGAAVkAMDEMNG
0	1		K389-u	EDRGAAVkAMDEMNG
0	1		K397-a	AMDEMNGkEIEGEEI
0	7		S426-p	RQAARQAsRstAyED
0	3		S428-p	AARQAsRstAyEDyy
0	1		T429-p	ARQAsRstAyEDyyy
0	51		Y431-p	QAsRstAyEDyyyHP
0	198		Y434-p	RstAyEDyyyHPPPR
0	214		Y435-p	stAyEDyyyHPPPRM
0	68		Y436-p	tAyEDyyyHPPPRMP
0	1		Y490	RGGYEDPYYGYDDGY
0	4		R500-m1	YDDGYAVrGrGGGRG
0	2		R502-m1	DGYAVrGrGGGRGGR
0	3		Y529-p	PPRGRAGysQrGAPL
0	3		S530-p	PRGRAGysQrGAPLG
0	1		R532-m1	GRAGysQrGAPLGPP
0	1		S542-p	PLGPPRGsRGGRGGP
0	12		K584-a	GYNQPDSkRRQtNNQ
0	2		T588-p	PDSkRRQtNNQQNWG
0	1		Y614-p	GGDYSGNyGyNNDNQ
0	1		Y616-p	DYSGNyGyNNDNQEF
0	14		Y624-p	NNDNQEFyQDtyGQQ
0	1		T627-p	NQEFyQDtyGQQWK_
0	6		Y628-p	QEFyQDtyGQQWK__

	mouse
K41	IEAGLPQKVAERLDE
K103	AFLCGVMKTYRQREK
K103-u	AFLCGVMkTYRQREK
K126	TKGPDEAKIKALLER
K128	GPDEAKIKALLERTG
K171	GTEVFVGKIPRDLYE
K187-u	ELVPLFEkAGPIWDL
Y208	LSGQNRGYAFITFCG
K224	EAAQEAVKLCDSYEI
Y229	AVKLCDSYEIRPGKH
S252-p	NNRLFVGsIPKNKTK
K259	sIPKNKTKENILEEF
K313	RRRLMSGKVKVWGNV
K341	PEVMAKVKVLFVRNL
K359-u	VTEEILEkSFSEFGk
K366	kSFSEFGKLERVKKL
K366-u	kSFSEFGkLERVKKL
K374	LERVKKLKDYAFVHF
Y376	RVKKLKDYAFVHFED
K389	EDRGAAVKAMDEMNG
K389	EDRGAAVKAMDEMNG
K397	AMDEMNGKEIEGEEI
S426	RQAARQASRSTAYED
S428	AARQASRSTAYEDYY
T429	ARQASRSTAYEDYYY
Y431	QASRSTAYEDYYYHP
Y434	RSTAYEDYYYHPPPR
Y435	STAYEDYYYHPPPRM
Y436	TAYEDYYYHPPPRMP
Y489-p	RGGYEDPyYGYDDGY
R499	YDDGYAVRGRGGGRG
R501	DGYAVRGRGGGRGGR
Y528	PPRGRAGYSQRGAPL
S529	PRGRAGYSQRGAPLG
R531	GRAGYSQRGAPLGPP
S541	PLGPPRGSRGGRGGP
K583	GYNQPDSKRRQTNNQ
T587	PDSKRRQTNNQQNWG
Y613	GGDYSGNYGYNNDNQ
Y615	DYSGNYGYNNDNQEF
Y623	NNDNQEFYQDTYGQQ
T626	NQEFYQDTYGQQWK_
Y627	QEFYQDTYGQQWK__

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