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Protein Page:
hnRNP R (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
hnRNP R Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; RNA splicing; Spliceosome
Cellular Component: nucleoplasm; spliceosome; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex
Molecular Function: protein binding; RNA binding; nucleotide binding
Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA processing
Reference #:  O43390 (UniProtKB)
Alt. Names/Synonyms: FLJ25714; Heterogeneous nuclear ribonucleoprotein R; hnRNP R; hnRNP-R; HNRNPR; HNRPR
Gene Symbols: HNRNPR
Molecular weight: 70,943 Da
Basal Isoelectric point: 8.23  Predict pI for various phosphorylation states
Select Structure to View Below

hnRNP R

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S22-p EEEPMDTsSVTHTEH
0 1 K41-ub IEAGLPQkVAERLDE
0 1 S78-p FNEEGALsVLQQFKE
0 8 K103-ac AFLCGVMkTYRQREK
0 2 K103-ub AFLCGVMkTYRQREK
0 1 K126-m3 TKGPDEAkIkALLER
0 1 K128-m3 GPDEAkIkALLERTG
0 2 K171-ub GTEVFVGkIPRDLyE
0 1 Y177-p GkIPRDLyEDELVPL
0 21 K187-ub ELVPLFEkAGPIWDL
0 2 Y208-p LSGQNRGyAFITFCG
0 1 K224-ub EAAQEAVkLCDSyEI
0 2 Y229-p AVkLCDSyEIRPGkH
0 1 K235-m1 SyEIRPGkHLGVCIS
0 5 S252-p NNRLFVGsIPKNKTk
0 1 K259-m1 sIPKNKTkENILEEF
0 1 K313-ub RRRLMSGkVKVWGNV
0 6 K341-ub PEVMAKVkVLFVRNL
0 10 K359-ub VTEEILEkSFsEFGk
0 1 S362-p EILEkSFsEFGkLER
0 3 K366-ac kSFsEFGkLERVKKL
0 37 K366-ub kSFsEFGkLERVKKL
0 1 K374-ub LERVKKLkDyAFVHF
0 1 Y376-p RVKKLkDyAFVHFED
0 1 K389-ac EDRGAAVkAMDEMNG
0 1 K389-ub EDRGAAVkAMDEMNG
0 1 K397-ac AMDEMNGkEIEGEEI
0 7 S426-p RQAARQAsRstAyED
0 3 S428-p AARQAsRstAyEDyy
0 1 T429-p ARQAsRstAyEDyyy
0 38 Y431-p QAsRstAyEDyyyHP
0 167 Y434-p RstAyEDyyyHPPPR
0 180 Y435-p stAyEDyyyHPPPRM
0 53 Y436-p tAyEDyyyHPPPRMP
0 1 R441 yyyHPPPRMPPPIRG
0 1 Y490 RGGYEDPYYGYDDGY
0 4 R500-m1 YDDGYAVrGrGGGRG
0 2 R502-m1 DGYAVrGrGGGRGGR
0 3 Y529-p PPRGRAGysQrGAPL
0 3 S530-p PRGRAGysQrGAPLG
0 1 R532-m1 GRAGysQrGAPLGPP
0 1 S542-p PLGPPRGsRGGRGGP
0 12 K584-ac GYNQPDSkRRQtNNQ
0 2 T588-p PDSkRRQtNNQQNWG
0 1 Y614-p GGDYSGNyGyNNDNQ
0 1 Y616-p DYSGNyGyNNDNQEF
0 13 Y624-p NNDNQEFyQDtyGQQ
0 1 T627-p NQEFyQDtyGQQWK_
0 5 Y628-p QEFyQDtyGQQWK__
  mouse

 
S22 EEEPMDTSSVTHTEH
K41 IEAGLPQKVAERLDE
S78 FNEEGALSVLQQFKE
K103 AFLCGVMKTYRQREK
K103-ub AFLCGVMkTYRQREK
K126 TKGPDEAKIKALLER
K128 GPDEAKIKALLERTG
K171 GTEVFVGKIPRDLYE
Y177 GKIPRDLYEDELVPL
K187-ub ELVPLFEkAGPIWDL
Y208 LSGQNRGYAFITFCG
K224 EAAQEAVKLCDSYEI
Y229 AVKLCDSYEIRPGKH
K235 SYEIRPGKHLGVCIS
S252-p NNRLFVGsIPKNKTK
K259 sIPKNKTKENILEEF
K313 RRRLMSGKVKVWGNV
K341 PEVMAKVKVLFVRNL
K359-ub VTEEILEkSFSEFGk
S362 EILEkSFSEFGkLER
K366 kSFSEFGKLERVKKL
K366-ub kSFSEFGkLERVKKL
K374 LERVKKLKDYAFVHF
Y376 RVKKLKDYAFVHFED
K389 EDRGAAVKAMDEMNG
K389 EDRGAAVKAMDEMNG
K397 AMDEMNGKEIEGEEI
S426 RQAARQASRSTAYED
S428 AARQASRSTAYEDYY
T429 ARQASRSTAYEDYYY
Y431 QASRSTAYEDYYYHP
Y434 RSTAYEDYYYHPPPr
Y435 STAYEDYYYHPPPrM
Y436 TAYEDYYYHPPPrMP
R441-m1 YYYHPPPrMPPPMRG
Y489-p RGGYEDPyYGYDDGY
R499 YDDGYAVRGRGGGRG
R501 DGYAVRGRGGGRGGR
Y528 PPRGRAGYSQRGAPL
S529 PRGRAGYSQRGAPLG
R531 GRAGYSQRGAPLGPP
S541 PLGPPRGSRGGRGGP
K583 GYNQPDSKRRQTNNQ
T587 PDSKRRQTNNQQNWG
Y613 GGDYSGNYGYNNDNQ
Y615 DYSGNYGYNNDNQEF
Y623 NNDNQEFYQDTYGQQ
T626 NQEFYQDTYGQQWK_
Y627 QEFYQDTYGQQWK__
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