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Protein Page:
hnRNP R (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
hnRNP R Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Spliceosome; RNA binding protein; RNA splicing
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: nucleoplasm; spliceosome; cytoplasm; nucleolus; ribonucleoprotein complex
Molecular Function: protein binding; RNA binding; nucleotide binding
Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA processing
Reference #:  O43390 (UniProtKB)
Alt. Names/Synonyms: FLJ25714; Heterogeneous nuclear ribonucleoprotein R; hnRNP R; hnRNP-R; HNRNPR; HNRPR
Gene Symbols: HNRNPR
Molecular weight: 70,943 Da
Basal Isoelectric point: 8.23  Predict pI for various phosphorylation states
Select Structure to View Below

hnRNP R

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S22-p EEEPMDTssVTHTEH
0 1 S23-p EEPMDTssVTHTEHY
0 1 T32-p THTEHYKtLIEAGLP
0 1 K41-ub IEAGLPQkVAERLDE
0 1 T52-p RLDEIFQtGLVAYVD
0 1 S78-p FNEEGALsVLQQFKE
0 8 K103-ac AFLCGVMkTYRQREK
0 2 K103-ub AFLCGVMkTYRQREK
0 1 K126-m3 TKGPDEAkIkALLER
0 1 K128-m3 GPDEAkIkALLERTG
0 2 K171-ub GTEVFVGkIPRDLyE
0 1 Y177-p GkIPRDLyEDELVPL
0 21 K187-ub ELVPLFEkAGPIWDL
0 2 Y208-p LSGQNRGyAFITFCG
0 1 K224-ub EAAQEAVkLCDsyEI
0 1 S228-p EAVkLCDsyEIRPGk
0 2 Y229-p AVkLCDsyEIRPGkH
0 1 K235-m1 syEIRPGkHLGVCIS
0 5 S252-p NNRLFVGsIPKNKTk
0 1 K259-m1 sIPKNKTkENILEEF
0 1 Y296-p RGFCFLEyEDHKSAA
0 1 K313-ub RRRLMSGkVKVWGNV
0 6 K341-ub PEVMAKVkVLFVRNL
0 9 K359-ub VTEEILEkSFsEFGk
0 1 S362-p EILEkSFsEFGkLER
0 3 K366-ac kSFsEFGkLERVKKL
0 36 K366-ub kSFsEFGkLERVKKL
0 1 K374-ub LERVKKLkDyAFVHF
0 2 Y376-p RVKKLkDyAFVHFED
0 1 K389-ac EDRGAAVkAMDEMNG
0 1 K389-ub EDRGAAVkAMDEMNG
0 1 K397-ac AMDEMNGkEIEGEEI
0 7 S426-p RQAARQAsRstAyED
0 3 S428-p AARQAsRstAyEDyy
0 1 T429-p ARQAsRstAyEDyyy
0 41 Y431-p QAsRstAyEDyyyHP
0 172 Y434-p RstAyEDyyyHPPPR
0 186 Y435-p stAyEDyyyHPPPRM
0 53 Y436-p tAyEDyyyHPPPRMP
0 1 R441 yyyHPPPRMPPPIRG
0 1 Y490 RGGYEDPYYGYDDGY
0 4 R500-m1 YDDGYAVrGrGGGRG
0 2 R502-m1 DGYAVrGrGGGRGGR
0 3 Y529-p PPRGRAGysQrGAPL
0 3 S530-p PRGRAGysQrGAPLG
0 1 R532-m1 GRAGysQrGAPLGPP
0 1 S542-p PLGPPRGsRGGRGGP
0 12 K584-ac GYNQPDSkRRQtNNQ
0 2 T588-p PDSkRRQtNNQQNWG
0 1 Y614-p GGDYSGNyGyNNDNQ
0 1 Y616-p DYSGNyGyNNDNQEF
0 15 Y624-p NNDNQEFyQDtyGQQ
0 1 T627-p NQEFyQDtyGQQWK_
0 5 Y628-p QEFyQDtyGQQWK__
  hnRNP R iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K171 GTEVFVGKIPRDLYE
Y177 GKIPRDLYEDELVPL
K187 ELVPLFEKAGPIWDL
Y208 LSGQNRGYAFITFCG
K224 EAAQEAVKLCDSYEI
S228 EAVKLCDSYEIRPGK
Y229 AVKLCDSYEIRPGKH
K235 SYEIRPGKHLGVCIS
S252 NNRLFVGSIPKNKTK
K259 SIPKNKTKENILEEF
Y299 RGFCFLEYEDHKSAA
K316 RRRLMSGKVKVWGNV
K344 PEVMAKVKVLFVRNL
K362 VTEEILEKSFSEFGK
S365 EILEKSFSEFGKLER
K369 KSFSEFGKLERVKKL
K369 KSFSEFGKLERVKKL
K377 LERVKKLKDYAFVHF
Y379 RVKKLKDYAFVHFED
K392 EDRGAAVKAMDEMNG
K392 EDRGAAVKAMDEMNG
K400 AMDEMNGKEIEGEEI
S429 RQAARQASRSTAYED
S431 AARQASRSTAYEDYY
T432 ARQASRSTAYEDYYY
Y434 QASRSTAYEDYYYHP
Y437 RSTAYEDYYYHPPPR
Y438 STAYEDYYYHPPPRM
Y439 TAYEDYYYHPPPRMP
R444 YYYHPPPRMPPPIRG
Y493 RGGYEDPYYGYDDGY
R503 YDDGYAVRGRGGGRG
R505 DGYAVRGRGGGRGGR
Y532 PPRGRAGYSQRGAPL
S533 PRGRAGYSQRGAPLG
R535 GRAGYSQRGAPLGPP
S545 PLGPPRGSRGGRGGP
K587 GYNQPDSKRRQTNNQ
T591 PDSKRRQTNNQQNWG
Y617 GGDYSGNYGYNNDNQ
Y619 DYSGNYGYNNDNQEF
Y627 NNDNQEFYQDTYGQQ
T630 NQEFYQDTYGQQWK_
Y631 QEFYQDTYGQQWK__
  hnRNP R iso3  
S22 EEEPMDTSSVTHTEH
S23 EEPMDTSSVTHTEHY
T32 THTEHYKTLIEAGLP
K41 IEAGLPQKVAERLDE
T52 RLDEIFQTGLVAYVD
S78 FNEEGALSVLQQFKE
K103 AFLCGVMKTYRQREK
K103 AFLCGVMKTYRQREK
K126 TKGPDEAKIKVFVGK
K128 GPDEAKIKVFVGKIP
K133 KIKVFVGKIPRDLYE
Y139 GKIPRDLYEDELVPL
K149 ELVPLFEKAGPIWDL
Y170 LSGQNRGYAFITFCG
K186 EAAQEAVKLCDSYEI
S190 EAVKLCDSYEIRPGK
Y191 AVKLCDSYEIRPGKH
K197 SYEIRPGKHLGVCIS
S214 NNRLFVGSIPKNKTK
K221 SIPKNKTKENILEEF
Y258 RGFCFLEYEDHKSAA
K275 RRRLMSGKVKVWGNV
K303 PEVMAKVKVLFVRNL
K321 VTEEILEKSFSEFGK
S324 EILEKSFSEFGKLER
K328 KSFSEFGKLERVKKL
K328 KSFSEFGKLERVKKL
K336 LERVKKLKDYAFVHF
Y338 RVKKLKDYAFVHFED
K351 EDRGAAVKAMDEMNG
K351 EDRGAAVKAMDEMNG
K359 AMDEMNGKEIEGEEI
S388 RQAARQASRSTAYED
S390 AARQASRSTAYEDYY
T391 ARQASRSTAYEDYYY
Y393 QASRSTAYEDYYYHP
Y396 RSTAYEDYYYHPPPR
Y397 STAYEDYYYHPPPRM
Y398 TAYEDYYYHPPPRMP
R403 YYYHPPPRMPPPIRG
Y452 RGGYEDPYYGYDDGY
R462 YDDGYAVRGRGGGRG
R464 DGYAVRGRGGGRGGR
Y491 PPRGRAGYSQRGAPL
S492 PRGRAGYSQRGAPLG
R494 GRAGYSQRGAPLGPP
S504 PLGPPRGSRGGRGGP
K546 GYNQPDSKRRQTNNQ
T550 PDSKRRQTNNQQNWG
Y576 GGDYSGNYGYNNDNQ
Y578 DYSGNYGYNNDNQEF
Y586 NNDNQEFYQDTYGQQ
T589 NQEFYQDTYGQQWK_
Y590 QEFYQDTYGQQWK__
  hnRNP R iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K70 GTEVFVGKIPRDLYE
Y76 GKIPRDLYEDELVPL
K86 ELVPLFEKAGPIWDL
Y107 LSGQNRGYAFITFCG
K123 EAAQEAVKLCDSYEI
S127 EAVKLCDSYEIRPGK
Y128 AVKLCDSYEIRPGKH
K134 SYEIRPGKHLGVCIS
S151 NNRLFVGSIPKNKTK
K158 SIPKNKTKENILEEF
Y198 RGFCFLEYEDHKSAA
K215 RRRLMSGKVKVWGNV
K243 PEVMAKVKVLFVRNL
K261 VTEEILEKSFSEFGK
S264 EILEKSFSEFGKLER
K268 KSFSEFGKLERVKKL
K268 KSFSEFGKLERVKKL
K276 LERVKKLKDYAFVHF
Y278 RVKKLKDYAFVHFED
K291 EDRGAAVKAMDEMNG
K291 EDRGAAVKAMDEMNG
K299 AMDEMNGKEIEGEEI
S328 RQAARQASRSTAYED
S330 AARQASRSTAYEDYY
T331 ARQASRSTAYEDYYY
Y333 QASRSTAYEDYYYHP
Y336 RSTAYEDYYYHPPPR
Y337 STAYEDYYYHPPPRM
Y338 TAYEDYYYHPPPRMP
R343 YYYHPPPRMPPPIRG
Y392 RGGYEDPYYGYDDGY
R402 YDDGYAVRGRGGGRG
R404 DGYAVRGRGGGRGGR
Y431 PPRGRAGYSQRGAPL
S432 PRGRAGYSQRGAPLG
R434 GRAGYSQRGAPLGPP
S444 PLGPPRGSRGGRGGP
K486 GYNQPDSKRRQTNNQ
T490 PDSKRRQTNNQQNWG
Y516 GGDYSGNYGYNNDNQ
Y518 DYSGNYGYNNDNQEF
Y526 NNDNQEFYQDTYGQQ
T529 NQEFYQDTYGQQWK_
Y530 QEFYQDTYGQQWK__
  mouse

 
S22 EEEPMDTSSVTHTEH
S23 EEPMDTSSVTHTEHY
T32 THTEHYKTLIEAGLP
K41 IEAGLPQKVAERLDE
T52 RLDEIFQTGLVAYVD
S78 FNEEGALSVLQQFKE
K103 AFLCGVMKTYRQREK
K103-ub AFLCGVMkTYRQREK
K126 TKGPDEAKIKALLER
K128 GPDEAKIKALLERTG
K171 GTEVFVGKIPRDLYE
Y177 GKIPRDLYEDELVPL
K187-ub ELVPLFEkAGPIWDL
Y208 LSGQNRGYAFITFCG
K224 EAAQEAVKLCDSYEI
S228 EAVKLCDSYEIRPGK
Y229 AVKLCDSYEIRPGKH
K235 SYEIRPGKHLGVCIS
S252-p NNRLFVGsIPKNKTK
K259 sIPKNKTKENILEEF
Y296 RGFCFLEYEDHKSAA
K313 RRRLMSGKVKVWGNV
K341 PEVMAKVKVLFVRNL
K359-ub VTEEILEkSFSEFGk
S362 EILEkSFSEFGkLER
K366 kSFSEFGKLERVKKL
K366-ub kSFSEFGkLERVKKL
K374 LERVKKLKDYAFVHF
Y376 RVKKLKDYAFVHFED
K389 EDRGAAVKAMDEMNG
K389 EDRGAAVKAMDEMNG
K397 AMDEMNGKEIEGEEI
S426 RQAARQASRSTAYED
S428 AARQASRSTAYEDYY
T429 ARQASRSTAYEDYYY
Y431 QASRSTAYEDYYYHP
Y434 RSTAYEDYYYHPPPr
Y435 STAYEDYYYHPPPrM
Y436 TAYEDYYYHPPPrMP
R441-m1 YYYHPPPrMPPPMRG
Y489-p RGGYEDPyYGYDDGY
R499 YDDGYAVRGRGGGRG
R501 DGYAVRGRGGGRGGR
Y528 PPRGRAGYSQRGAPL
S529 PRGRAGYSQRGAPLG
R531 GRAGYSQRGAPLGPP
S541 PLGPPRGSRGGRGGP
K583 GYNQPDSKRRQTNNQ
T587 PDSKRRQTNNQQNWG
Y613 GGDYSGNYGYNNDNQ
Y615 DYSGNYGYNNDNQEF
Y623 NNDNQEFYQDTYGQQ
T626 NQEFYQDTYGQQWK_
Y627 QEFYQDTYGQQWK__
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