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Protein Page:
TyroBP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TyroBP Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Belongs to the TYROBP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: identical protein binding; protein binding; receptor signaling protein activity; receptor binding
Biological Process: integrin-mediated signaling pathway; axon guidance; regulation of immune response; neutrophil activation during immune response; macrophage activation during immune response; innate immune response; cellular defense response; signal transduction
Reference #:  O43914 (UniProtKB)
Alt. Names/Synonyms: DAP12; DNAX-activation protein 12; KAR-associated protein; KARAP; killer activating receptor associated protein; Killer-activating receptor-associated protein; PLOSL; TYOBP; TYRO protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein; TYROBP
Gene Symbols: TYROBP
Molecular weight: 12,179 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TyroBP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K81 AAEAATRKQRITETE
0 14 S89-p QRITETEsPyQELQG
1 255 Y91-p ITETEsPyQELQGQR
1 20 Y102-p QGQRSDVySDLNTQR
0 1 S103 GQRSDVySDLNTQRP
0 1 Y111-p DLNTQRPyyK_____
0 2 Y112-p LNTQRPyyK______
  TyroBP iso2  
K80 GAAEATRKQRITETE
S88 QRITETESPyQELQG
Y90-p ITETESPyQELQGQR
Y101-p QGQRSDVySDLNTQR
S102 GQRSDVySDLNTQRP
Y110-p DLNTQRPyyK_____
Y111-p LNTQRPyyK______
  mouse

 
K82-ub GTAEGTRkQHIAETE
S90-p QHIAETEsPyQELQG
Y92-p IAETEsPyQELQGQR
Y103-p QGQRPEVysDLNTQR
S104-p GQRPEVysDLNTQRQ
Y112 DLNTQRQYYR_____
Y113 LNTQRQYYR______
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