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Protein Page:
POLR1D (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
POLR1D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. Defects in POLR1D are the cause of Treacher Collins syndrome type 2 (TCS2). A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; cytosol; DNA-directed RNA polymerase I complex
Molecular Function: protein dimerization activity; DNA binding
Biological Process: transcription from RNA polymerase III promoter; termination of RNA polymerase III transcription; positive regulation of interferon type I production; innate immune response; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; RNA elongation from RNA polymerase III promoter
Reference #:  Q9Y2S0 (UniProtKB)
Alt. Names/Synonyms: AC19; DNA-directed RNA polymerase I subunit D; DNA-directed RNA polymerases I and III subunit RPAC2; FLJ20616; hRPA19; MGC9850; POLR1C; POLR1D; polymerase (RNA) I polypeptide D, 16kDa; RNA polymerase I 16 kDa subunit; RNA polymerases I and III subunit AC2; RPA16; RPA9; RPAC2; RPC16; RPO1-3
Gene Symbols: POLR1D
Molecular weight: 15,237 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Select Structure to View Below

POLR1D

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K10 EDQELERKIsGLktS
0 5 S12-p QELERKIsGLktSMA
0 1 K15-ub ERKIsGLktSMAEGE
0 1 T16-p RKIsGLktSMAEGER
0 1 T25-p MAEGERKtALEMVQA
0 1 T35-p EMVQAAGtDRHCVTF
0 1 K122 EASIKDYKDQKASRN
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 8 - gap
0 6 - gap
0 16 - gap
  POLR1D iso2  
K10 EDQELERKAIEELLK
- gap
- gap
- under review  
- gap
- gap
- gap
T28 RGKTRAETMGPMGWM
K70-ac HEQKEGDkEPAkSQA
K74-ac EGDkEPAkSQAQkEE
K79-ac PAkSQAQkEENPKKH
S94-p RSHPYKHsFRARGSA
S102-p FRARGSAsYsPPRKR
S104-p ARGSAsYsPPRKRSS
  mouse

► Hide Isoforms
 
K10-ac DDQELERkISGLKTS
S12 QELERkISGLKTSMA
K15 ERkISGLKTSMAEGE
T16 RkISGLKTSMAEGER
T25 MAEGERKTALEMVQA
T35 EMVQAAGTDRQCVTF
K122-ac EASIKDYkAKKASKK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  POLR1D iso2  
K10 DDQELERKAIEELLK
- gap
- gap
- under review  
- gap
- gap
- gap
T28-p RGKTRAEtMGPMGWM
K70 HEQKEGSKEPGKSQD
K74 EGSKEPGKSQDQKEA
K79 PGKSQDQKEASGKKY
S94 RSHSYKRSLHSSRGS
G103 HSSRGSAGCsPPRKR
S105-p SRGSAGCsPPRKRTS
  rat

 
K10 DDQELERKAIEELLK
- gap
- gap
- under review  
- gap
- gap
- gap
T28 RGKTRAETMGPMGWM
K70 HEQKEGSKEPGKSQD
K74 EGSKEPGKSQDQKET
K79 PGKSQDQKETSGKKH
S94 RSHSYKRSLHSARGS
G103 HSARGSVGCsPPRKR
S105-p ARGSVGCsPPRKRAS
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