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GAD67 (human)

Overview GAD67 Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Lyase; EC 4.1.1.15; Other Amino Acids Metabolism - taurine and hypotaurine; Other Amino Acids Metabolism - beta-alanine Cellular Component: plasma membrane; intracellular; vesicle membrane Molecular Function: protein binding; glutamate decarboxylase activity; pyridoxal phosphate binding Biological Process: response to drug; glutamate catabolic process; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; protein-pyridoxal-5-phosphate linkage; neurotransmitter biosynthetic process Reference #:  Q99259 (UniProtKB) Alt. Names/Synonyms: 67 kDa glutamic acid decarboxylase; DCE1; FLJ45882; GAD; GAD-67; GAD1; GAD67; Glutamate decarboxylase 1; glutamate decarboxylase 1 (brain, 67kDa); Glutamate decarboxylase 67 kDa isoform; SCP Gene Symbols: GAD1 Molecular weight: 66,897 Da Basal Isoelectric point: 7.54  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GAD67 2OKJ - A/B=93-594 (human) 3VP6 - A/B=90-594 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2OKJ 3VP6  |  ENZYME  |  Phospho3D  |  DISEASE 603513 605363  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S56	GFLQRTNSLEEKSRL
0	1		K60	RTNSLEEKSRLVSAF
0	2		S72	SAFKERQSsKNLLSC
0	3		S73-p	AFKERQSsKNLLSCE
0	4		K74	FKERQSsKNLLSCEN
0	6		S78	QSsKNLLSCENSDRD
1	0		T91-p	RDARFRRtETDFSNL
0	35		Y265-p	YSIMAARyKYFPEVK
0	1		K471	FWLMWKAKGTVGFEN
0	1		S571-p	NFFRMVIsNPAATQS

	mouse
S55-p	GFLQRTNsLEEKSRL
K59	RTNsLEEKSRLVSAF
S71-p	SAFRERQssKNLLsC
S72-p	AFRERQssKNLLsCE
K73	FRERQssKNLLsCEN
S77-p	QssKNLLsCENSDQG
T90	QGARFRRTETDFSNL
Y264	YSIMAARYKYFPEVK
K470-u	FWLMWKAkGTVGFEN
S570	NFFRMVISNPAATQS

	rat
S55	GFLQRTNSLEEkSRL
K59-u	RTNSLEEkSRLVSAF
A71	SAFRERQASkNLLSC
S72	AFRERQASkNLLSCE
K73-u	FRERQASkNLLSCEN
S77	QASkNLLSCENSDPG
T90	PGARFRRTETDFSNL
Y264-p	YSIMAARyKYFPEVK
K470	FWLMWKAKGTVGFEN
S570	NFFRMVISNPAATQS

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