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FGF2 (mouse)

Overview FGF2 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Activator protein Cellular Component: extracellular space; cytoplasm; extracellular region; cytosol; nucleus Molecular Function: heparin binding; protein binding; fibroblast growth factor binding; ligand-dependent nuclear receptor transcription coactivator activity; growth factor activity; cytokine activity; fibroblast growth factor receptor binding; chemoattractant activity Biological Process: activation of MAPKK activity; regulation of cell cycle; positive regulation of transcription, DNA-dependent; multicellular organismal development; adrenocorticotropin hormone secreting cell differentiation; hyaluronan catabolic process; substantia nigra development; positive chemotaxis; induction of an organ; positive regulation of cardiac muscle cell proliferation; fibroblast growth factor receptor signaling pathway; positive regulation of cell fate specification; positive regulation of blood vessel endothelial cell migration; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; nuclear translocation of MAPK; cell migration during sprouting angiogenesis; positive regulation of cell division; phosphatidylinositol biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; apoptosis; protein kinase cascade; thyroid stimulating hormone secreting cell differentiation; cardiac muscle cell proliferation; signal transduction; negative regulation of cell proliferation; glial cell differentiation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; regulation of retinal cell programmed cell death; angiogenesis; response to axon injury; cell differentiation; positive regulation of granule cell precursor proliferation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of osteoblast differentiation; stem cell development; embryonic development; ureteric bud branching; release of sequestered calcium ion into cytosol; C21-steroid hormone biosynthetic process; negative regulation of cell growth; positive regulation of protein amino acid phosphorylation; inositol phosphate biosynthetic process; lung development Reference #:  P15655 (UniProtKB) Alt. Names/Synonyms: Basic fibroblast growth factor; BFGF; Fgf-2; Fgf2; Fgfb; fibroblast growth factor 2; HBGF-2; Heparin-binding growth factor 2 Gene Symbols: Fgf2 Molecular weight: 17,153 Da Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states

Select Structure to View Below FGF2 1BAS - A=2-155 (human) 1BFB - A=9-155 (human) 1BFC - A=9-155 (human) 1BFF - A=27-155 (human) 1BFG - A=10-155 (human) 1BLA - A=1-155 (human) 1BLD - A=1-155 (human) 1FGA - A=10-155 (human) 2BFH - A=28-155 (human) 2FGF - A=10-155 (human) 4FGF - A=10-155 (human)

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	Sites Implicated In
intracellular localization: Y81‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		-	gap
0	1		-	gap
1	0		-	gap
1	0		-	gap
1	0		-	gap
1	0		-	gap
1	0		-	gap
1	0		-	gap
1	0		-	gap
1	0		-	gap
0	1		S4	____MAASGITSLPA
0	1		S8	MAASGITSLPALPED
2	0		K34	DPKRLYCKNGGFFLR
1	0		S72	AEERGVVSIKGVCAN
1	0		Y81-p	KGVCANRyLAMKEDG
0	1		K94	DGRLLASKCVTEECF
1	2		Y111-p	ERLESNNyNTYRSRK
1	0		S116	NNyNTYRSRKYSSWy
1	0		S120	TYRSRKYSSWyVALK
1	0		Y123-p	SRKYSSWyVALKRTG
2	0		K127	SSWyVALKRTGQYKL
1	0		K133	LKRTGQYKLGSKTGP
1	0		K137	GQYKLGSKTGPGQKA
2	0		K143	SKTGPGQKAILFLPM
0	1		S151	AILFLPMSAKS____

	human
S62-p	PRSRAAGsPRtRGRR
T65-p	RAAGsPRtRGRRTEE
R82-m2	SGSRLGDrGrGrALP
R84-m2	SRLGDrGrGrALPGG
R86-m2	LGDrGrGrALPGGRL
R96-m2	PGGRLGGrGrGRAPE
R98-m2	GRLGGrGrGRAPERV
R108-m2	APERVGGrGrGrGTA
R110-m2	ERVGGrGrGrGTAAP
R112-m2	VGGrGrGrGTAAPRA
S138-p	AGTMAAGsITtLPAL
T141-p	MAAGsITtLPALPED
K168-a	DPKRLYCkNGGFFLR
S206-p	AEERGVVsIKGVCAN
Y215	KGVCANRYLAMKEDG
K228-u	DGRLLASkCVTDECF
Y245-p	ERLESNNyNTYRsRK
S250-p	NNyNTYRsRKYtSWY
T254-p	TYRsRKYtSWYVALk
Y257	sRKYtSWYVALkRTG
K261-a	tSWYVALkRTGQYkL
K267-a	LkRTGQYkLGSkTGP
K271-a	GQYkLGSkTGPGQkA
K277-a	SkTGPGQkAILFLPM
S285-p	AILFLPMsAKS____

	rat
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S5	___MAAGSITSLPAL
S8	MAAGSITSLPALPED
K34	DPKRLYCKNGGFFLR
S72	AEERGVVSIKGVCAN
Y81	KGVCANRYLAMKEDG
K94	DGRLLASKCVTEECF
Y111	ERLESNNYNTYRSRK
S116	NNYNTYRSRKYSSWY
S120	TYRSRKYSSWYVALK
Y123	SRKYSSWYVALKRTG
K127	SSWYVALKRTGQYKL
K133	LKRTGQYKLGSKTGP
K137	GQYKLGSKTGPGQKA
K143	SKTGPGQKAILFLPM
S151	AILFLPMSAKS____

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