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Protein Page:
ALDOB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ALDOB Defects in ALDOB are the cause of hereditary fructose intolerance (HFI). HFI is an autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. Belongs to the class I fructose-bisphosphate aldolase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose; Lyase; EC 4.1.2.13; Carbohydrate Metabolism - pentose phosphate pathway
Cellular Component: microtubule organizing center; cytosol
Molecular Function: identical protein binding; protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; ATPase binding
Biological Process: fructose 1,6-bisphosphate metabolic process; NADH oxidation; glycolysis; positive regulation of ATPase activity; carbohydrate metabolic process; glucose metabolic process; fructose catabolic process; gluconeogenesis; fructose metabolic process
Reference #:  P05062 (UniProtKB)
Alt. Names/Synonyms: ALDB; ALDO2; ALDOB; aldolase 2; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; Fructose-bisphosphate aldolase B; Liver-type aldolase
Gene Symbols: ALDOB
Molecular weight: 39,473 Da
Basal Isoelectric point: 8.01  Predict pI for various phosphorylation states
Select Structure to View Below

ALDOB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K13-ac PALTQEQkKELSEIA
0 1 K13 PALTQEQKKELSEIA
0 1 K14 ALTQEQkKELSEIAQ
0 1 K14 ALTQEQkKELSEIAQ
0 1 K14 ALTQEQkKELSEIAQ
0 1 K28 QSIVANGKGILAADE
0 6 S36-p GILAADEsVGtMGNR
0 6 T39-p AADEsVGtMGNRLQR
0 2 K48 GNRLQRIKVENTEEN
0 1 S89-p ETLYQKDsQGKLFRN
0 1 K101 FRNILKEKGIVVGIK
0 2 K108 KGIVVGIKLDQGGAP
0 2 K108 KGIVVGIKLDQGGAP
0 1 K108 KGIVVGIKLDQGGAP
0 1 T119-p GGAPLAGtNKEttIQ
0 2 K121 APLAGtNKEttIQGL
0 2 K121 APLAGtNKEttIQGL
0 1 K121 APLAGtNKEttIQGL
0 2 T123-p LAGtNKEttIQGLDG
0 2 T124-p AGtNKEttIQGLDGL
0 1 S132-p IQGLDGLsERCAQYk
0 9 K139-ac sERCAQYkKDGVDFG
0 1 K140 ERCAQYkKDGVDFGk
0 9 K147-ac KDGVDFGkWRAVLRI
0 1 K147 KDGVDFGKWRAVLRI
0 1 K147 KDGVDFGKWRAVLRI
0 2 S161-p IADQCPSsLAIQENA
0 171 Y204-p HDLEHCQyVtEkVLA
0 9 T206-p LEHCQyVtEkVLAAV
0 2 K208-ac HCQyVtEkVLAAVYK
0 28 K208-ub HCQyVtEkVLAAVYK
0 11 Y223-p ALNDHHVyLEGTLLK
0 1 K230 yLEGTLLKPNMVTAG
0 1 K230 yLEGTLLKPNMVTAG
0 1 T241-p VTAGHACtkkYTPEQ
0 7 K242-ac TAGHACtkkYTPEQV
0 1 K242 TAGHACtKkYTPEQV
0 4 K243-ac AGHACtkkYTPEQVA
0 1 K243 AGHACtkKYTPEQVA
0 2 S272-p VPGICFLsGGMsEED
0 1 S276-p CFLsGGMsEEDATLN
0 8 Y302-p PWKLSFSyGRALQAs
0 2 S309-p yGRALQAsALAAWGG
0 1 K317 ALAAWGGKAANKEAT
0 1 K317 ALAAWGGKAANKEAT
0 1 E322 GGKAANKEATQEAFM
0 7 K330-ac ATQEAFMkRAMANCQ
0 2 K330 ATQEAFMKRAMANCQ
0 1 K330 ATQEAFMKRAMANCQ
1 1 Y362-p QSLFTACytY_____
0 1 T363-p SLFTACytY______
  mouse

 
K13-ac PALTPEQkkELSEIA
K13-sc PALTPEQkkELSEIA
K14-ac ALTPEQkkELSEIAQ
K14-ub ALTPEQkkELSEIAQ
K14-sc ALTPEQkkELSEIAQ
K28-ub QRIVANGkGILAADE
S36-p GILAADEsVGtMGNR
T39-p AADEsVGtMGNRLQR
K48-ub GNRLQRIkVENTEEN
S89 ETLYQKDSQGNLFRN
K101-ub FRNVLKEkGIVVGIk
K108-ac kGIVVGIkLDQGGAP
K108-ub kGIVVGIkLDQGGAP
K108-sc kGIVVGIkLDQGGAP
T119 GGAPLAGTNkETTIQ
K121-ac APLAGTNkETTIQGL
K121-ub APLAGTNkETTIQGL
K121-sc APLAGTNkETTIQGL
T123 LAGTNkETTIQGLDG
T124 AGTNkETTIQGLDGL
S132 IQGLDGLSERCAQYk
K139-ac SERCAQYkkDGVDFG
K140-ub ERCAQYkkDGVDFGk
K147-ac kDGVDFGkWRAVLRI
K147-ub kDGVDFGkWRAVLRI
K147-sc kDGVDFGkWRAVLRI
S161-p IADQCPSsLAIQENA
Y204-p HDLEHCQyVsEKVLA
S206-p LEHCQyVsEKVLAAV
K208 HCQyVsEKVLAAVYK
K208 HCQyVsEKVLAAVYK
Y223-p ALNDHHVyLEGTLLk
K230-ac yLEGTLLkPNMVTAG
K230-ub yLEGTLLkPNMVTAG
T241 VTAGHACTkkYTPEQ
K242-ac TAGHACTkkYTPEQV
K242-ub TAGHACTkkYTPEQV
K243-ac AGHACTkkYTPEQVA
K243-ub AGHACTkkYTPEQVA
S272-p VPGICFLsGGMSEED
S276 CFLsGGMSEEDATLN
Y302 PWKLSFSYGRALQAS
S309 YGRALQASALAAWGG
K317-ub ALAAWGGkAANKkAT
K317-sc ALAAWGGkAANKkAT
K322-ub GGkAANKkATQEAFM
K330-ac ATQEAFMkRAMANCQ
K330-ub ATQEAFMkRAMANCQ
K330-sc ATQEAFMkRAMANCQ
Y362 QSLFTASYTY_____
T363 SLFTASYTY______
  rat

 
K13 PALTSEQKKELSEIA
K13 PALTSEQKKELSEIA
K14 ALTSEQKKELSEIAQ
K14 ALTSEQKKELSEIAQ
K14 ALTSEQKKELSEIAQ
K28 QRIVANGKGILAADE
S36-p GILAADEsVGtMGNR
T39-p AADEsVGtMGNRLQR
K48 GNRLQRIKVENTEEN
S89 ETLYQKDSQGKLFRN
K101 FRNILKEKGIVVGIK
K108 KGIVVGIKLDQGGAP
K108 KGIVVGIKLDQGGAP
K108 KGIVVGIKLDQGGAP
T119 GGAPLAGTNKETTIQ
K121 APLAGTNKETTIQGL
K121 APLAGTNKETTIQGL
K121 APLAGTNKETTIQGL
T123 LAGTNKETTIQGLDG
T124 AGTNKETTIQGLDGL
S132-p IQGLDGLsERCAQYK
K139 sERCAQYKKDGVDFG
K140 ERCAQYKKDGVDFGK
K147 KDGVDFGKWRAVLRI
K147 KDGVDFGKWRAVLRI
K147 KDGVDFGKWRAVLRI
S161-p ISDQCPSsLAIQENA
Y204 HDLEHCQYVSEKVLA
S206 LEHCQYVSEKVLAAV
K208 HCQYVSEKVLAAVYK
K208 HCQYVSEKVLAAVYK
Y223 ALNDHHVYLEGTLLK
K230 YLEGTLLKPNMLTAG
K230 YLEGTLLKPNMLTAG
T241 LTAGHACTKKYTPEQ
K242 TAGHACTKKYTPEQV
K242 TAGHACTKKYTPEQV
K243 AGHACTKKYTPEQVA
K243 AGHACTKKYTPEQVA
S272 VPSICFLSGGMSEED
S276 CFLSGGMSEEDATLN
Y302 PWKLSFSYGRALQAS
S309 YGRALQASALAAWGG
K317 ALAAWGGKAANKKAT
K317 ALAAWGGKAANKKAT
K322 GGKAANKKATQEAFM
K330 ATQEAFMKRAVANCQ
K330 ATQEAFMKRAVANCQ
K330 ATQEAFMKRAVANCQ
Y362 QSLFTASYTY_____
T363 SLFTASYTY______
  rabbit

 
K13 PALTPEQKKELSDIA
K13 PALTPEQKKELSDIA
K14 ALTPEQKKELSDIAQ
K14 ALTPEQKKELSDIAQ
K14 ALTPEQKKELSDIAQ
K28 QRIVANGKGILAADE
S36 GILAADESVGTMGNR
T39 AADESVGTMGNRLQR
K48 GNRLQRIKVENTEEN
S89 ETLYQKDSQGKLFRN
K101 FRNILKEKGIVVGIK
K108 KGIVVGIKLDQGGAP
K108 KGIVVGIKLDQGGAP
K108 KGIVVGIKLDQGGAP
T119 GGAPLAGTNKETTIQ
K121 APLAGTNKETTIQGL
K121 APLAGTNKETTIQGL
K121 APLAGTNKETTIQGL
T123 LAGTNKETTIQGLDG
T124 AGTNKETTIQGLDGL
S132 IQGLDGLSERCAQYK
K139 SERCAQYKKDGVDFG
K140 ERCAQYKKDGVDFGK
K147 KDGVDFGKWRAVLRI
K147 KDGVDFGKWRAVLRI
K147 KDGVDFGKWRAVLRI
S161 IADQCPSSLAIQENA
Y204 HDLEHCQYVTEKVLA
T206 LEHCQYVTEKVLAAV
K208 HCQYVTEKVLAAVYK
K208 HCQYVTEKVLAAVYK
Y223 ALNDHHVYLEGTLLK
K230 YLEGTLLKPNMVTAG
K230 YLEGTLLKPNMVTAG
T241 VTAGHACTKKYTPEQ
K242 TAGHACTKKYTPEQV
K242 TAGHACTKKYTPEQV
K243 AGHACTKKYTPEQVA
K243 AGHACTKKYTPEQVA
S272 VPGICFLSGGMSEED
S276 CFLSGGMSEEDATLN
Y302 PWKLSFSYGRALQAS
S309 YGRALQASALAAWGG
K317 ALAAWGGKAENKKAT
K317 ALAAWGGKAENKKAT
K322 GGKAENKKATQEAFM
K330 ATQEAFMKRAVVNCQ
K330 ATQEAFMKRAVVNCQ
K330 ATQEAFMKRAVVNCQ
Y362-p QSLFTASyTY_____
T363 SLFTASyTY______
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