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Protein Page:
GFAT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GFAT2 Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Highest levels of expression in heart, placenta, and spinal cord. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.16; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Transferase
Cellular Component: cytosol
Molecular Function: carbohydrate binding; glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; energy reserve metabolic process; UDP-N-acetylglucosamine biosynthetic process; protein amino acid N-linked glycosylation via asparagine; glutamine metabolic process; post-translational protein modification; fructose 6-phosphate metabolic process; carbohydrate biosynthetic process
Reference #:  O94808 (UniProtKB)
Alt. Names/Synonyms: D-fructose-6-phosphate amidotransferase 2; FLJ10380; GFAT 2; GFAT2; GFPT2; Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine-fructose-6-phosphate transaminase 2; glutamine: fructose-6-phosphate aminotransferase 2; Glutamine:fructose 6 phosphate amidotransferase 2; Hexosephosphate aminotransferase 2
Gene Symbols: GFPT2
Molecular weight: 76,931 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GFAT2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K50-ub DGNNHEVkERHIQLV
0 1 T144-p GYEFESEtDTETIAK
1 1 S202-p AVATRRGsPLLIGVR
0 2 T227-p PILYRTCtLENVKNI
0 87 S244-p TRMKRLDssACLHAV
0 10 S245-p RMKRLDssACLHAVG
0 1 A246 MKRLDssACLHAVGD
0 1 K254-ac CLHAVGDkAVEFFFA
0 1 K328-ub NFSAFMQkEIFEQPE
0 1 T385 SYHAAVATRQVLEEL
0 1 T444-p CKDRGALtVGVTNTV
  mouse

 
K50 DGNNHEVKERHIHLV
T144 GYEFESETDTETIAK
S202-p AVATRRGsPLLIGVR
N227 PVLYPTCNIENVKNI
S244-p TRMKRLDsstCLHAV
S245-p RMKRLDsstCLHAVG
T246-p MKRLDsstCLHAVGD
K254 CLHAVGDKAVEFFFA
K328 NFSAFMQKEIFEQPE
T385-p SYHAAVAtRQVLEEL
T444 CKDRGALTVGITNTV
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