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Protein Page:
GFAT2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GFAT2 Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Highest levels of expression in heart, placenta, and spinal cord. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.16; Transferase
Cellular Component: cytosol
Molecular Function: glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate binding
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; energy reserve metabolic process; UDP-N-acetylglucosamine biosynthetic process; glutamine metabolic process; protein amino acid N-linked glycosylation via asparagine; fructose 6-phosphate metabolic process; post-translational protein modification; carbohydrate biosynthetic process
Reference #:  O94808 (UniProtKB)
Alt. Names/Synonyms: D-fructose-6-phosphate amidotransferase 2; FLJ10380; GFAT 2; GFAT2; GFPT2; Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine-fructose-6-phosphate transaminase 2; glutamine: fructose-6-phosphate aminotransferase 2; Glutamine:fructose 6 phosphate amidotransferase 2; Hexosephosphate aminotransferase 2
Gene Symbols: GFPT2
Molecular weight: 76,931 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GFAT2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S202-p AVATRRGsPLLIGVR
0 2 T227-p PILYRTCtLENVKNI
0 86 S244-p TRMKRLDssACLHAV
0 8 S245-p RMKRLDssACLHAVG
0 1 K328-u NFSAFMQkEIFEQPE
  mouse

 
S202-p AVATRRGsPLLIGVR
N227 PVLYPTCNIENVKNI
S244-p TRMKRLDssTCLHAV
S245-p RMKRLDssTCLHAVG
K328 NFSAFMQKEIFEQPE
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