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Protein Page:
Desmoplakin-3 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Desmoplakin-3 Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: desmosome; internal side of plasma membrane; apicolateral plasma membrane; basolateral plasma membrane; intermediate filament; intercellular junction; catenin complex; zonula adherens; fascia adherens; cytosol; beta-catenin destruction complex; Z disc; actin cytoskeleton; cytoskeleton; cell-cell adherens junction; membrane; cytoplasm; plasma membrane; nucleus; cell junction; lateral plasma membrane
Molecular Function: protein binding; cadherin binding; transcription coactivator activity; structural molecule activity; protein kinase binding; protein phosphatase binding; alpha-catenin binding
Biological Process: skin development; nervous system development; cell migration; cytoskeletal anchoring; protein heterooligomerization; cell morphogenesis; detection of mechanical stimulus; gastrulation; regulation of cell proliferation; cell-cell adhesion; morphogenesis of embryonic epithelium; positive regulation of protein import into nucleus; ectoderm development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; cell adhesion; oocyte development
Reference #:  Q02257 (UniProtKB)
Alt. Names/Synonyms: AL022715; AW545708; D930025P04Rik; Desmoplakin III; Desmoplakin-3; gamma-catenin; Junction plakoglobin; Jup; OTTMUSP00000006595; OTTMUSP00000006596; PG; PLAK; plakoglobin
Gene Symbols: Jup
Molecular weight: 81,801 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Desmoplakin-3

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 T14 IEQPIKVTEWQQTYT
0 1 T19 KVTEWQQTYTYDSGI
0 122 Y20 VTEWQQTYTYDSGIH
0 8 T21 TEWQQTYTYDSGIHS
0 55 Y22 EWQQTYTYDSGIHSG
0 1 S24 QQTYTYDSGIHSGVN
0 1 K40 CVPSVSSKGIMDEDD
0 13 Y53-p DDACGRQytLkkTTT
0 26 T54-p DACGRQytLkkTTTY
0 1 K56-ac CGRQytLkkTTTYTQ
0 1 K57-ub GRQytLkkTTTYTQG
0 3 T58 RQytLkkTTTYTQGV
0 3 T59 QytLkkTTTYTQGVP
0 3 T60 ytLkkTTTYTQGVPQ
0 8 Y61 tLkkTTTYTQGVPQN
0 3 T62 LkkTTTYTQGVPQNQ
0 10 N68 YTQGVPQNQGDLEYQ
0 114 Y74 QNQGDLEYQMsTTAR
0 1 S77-p GDLEYQMsTTARAKR
0 2 S99 GVSGEDSSLLLATQV
0 1 S120 LQRLAEPSQLLkSAI
0 3 K124-ub AEPSQLLkSAIVHLI
0 1 S125 EPSQLLkSAIVHLIN
1 1 Y133 AIVHLINYQDDAELA
0 1 T141 QDDAELATRALPELT
0 1 K149 RALPELTKLLNDEDP
0 1 T160 DEDPVVVTKAAMIVN
0 2 K161 EDPVVVTKAAMIVNQ
0 1 K171-ub MIVNQLSkKEASRRA
0 14 S182-p SRRALMGsPQLVAAV
0 7 T196 VVRTMQNTSDLDTAR
0 1 T205-p DLDTARCtTSILHNL
0 3 K224-ub EGLLAIFkSGGIPAL
0 1 K345 LSVCPSNKPAIVEAG
0 1 K385 NLSDVATKQEGLESV
0 1 T430 SKNKTLVTQNSGVEA
0 1 K448-ub AILRAGDkDDITEPA
0 1 T463 VCALRHLTSRHPEAE
0 104 Y480-p QNSVRLNyGIPAIVK
0 8 K499 PNQWPLVKATIGLIR
1 137 Y550 AAGTQQPYTDGVRME
0 1 T551 AGTQQPYTDGVRMEE
0 1 S596 FVQLLYSSVENIQRV
1 30 Y644 RNEGTATYAAAVLFR
0 147 Y660 SEDKNPDYRKRVsVE
0 14 S665-p PDYRKRVsVELTNsL
0 1 T669 KRVsVELTNsLFKHD
0 1 S671-p VsVELTNsLFKHDPA
0 1 Y693 MIPINEPYADDMDAT
0 4 Y701 ADDMDATYRPMYSSD
0 5 Y724 HMDLDGDYPMDTYSD
0 3 T728 DGDYPMDTYSDGLRP
0 4 Y729 GDYPMDTYSDGLRPP
0 1 S730 DYPMDTYSDGLRPPY
  human

 
T14-gl MEQPIKVtEWQQtyt
T19-p KVtEWQQtytyDsGI
Y20-p VtEWQQtytyDsGIH
T21-p tEWQQtytyDsGIHS
Y22-p EWQQtytyDsGIHSG
S24-p QQtytyDsGIHSGAN
K40-ub CVPSVSSkGIMEEDE
Y53-p DEACGRQytLKKttt
T54-p EACGRQytLKKttty
K56 CGRQytLKKtttytQ
K57 GRQytLKKtttytQG
T58-p RQytLKKtttytQGV
T59-p QytLKKtttytQGVP
T60-p ytLKKtttytQGVPP
Y61-p tLKKtttytQGVPPs
T62-p LKKtttytQGVPPsQ
S68-p ytQGVPPsQGDLEyQ
Y74-p PsQGDLEyQMsTTAR
S77-p GDLEyQMsTTARAKR
S99-p GVSGEDSsLLLATQV
S120-p LQRLAEPsQLLksAI
K124-ub AEPsQLLksAIVHLI
S125-p EPsQLLksAIVHLIN
Y133-p AIVHLINyQDDAELA
T141-p QDDAELAtRALPELT
K149-ub RALPELTkLLNDEDP
T160-p DEDPVVVtkAAMIVN
K161-ub EDPVVVtkAAMIVNQ
K171 MIVNQLSKKEASRRA
S182-p SRRALMGsPQLVAAV
T196-p VVRTMQNtSDLDTAR
T205 DLDTARCTTSILHNL
K224-ub EGLLAIFkSGGIPAL
K345-ub LSVCPSNkPAIVEAG
K385-ub NLSDVATkQEGLESV
T430-p SKNKTLVtQNSGVEA
K448 AILRAGDKDDITEPA
T463-p VCALRHLtSRHPEAE
Y480-p QNSVRLNyGIPAIVK
K499-ub PNQWPLVkATIGLIR
Y550-p AAGTQQPytDGVRME
T551-p AGTQQPytDGVRMEE
S596-p FVQLLYSsVENIQRV
Y644-p RNEGTATyAAAVLFR
Y660-p SEDKNPDyRKRVsVE
S665-p PDyRKRVsVELtNSL
T669-p KRVsVELtNSLFKHD
S671 VsVELtNSLFKHDPA
Y693 MIPINEPYGDDMDAT
Y701-p GDDMDATyRPMYSSD
Y724-p HMDMDGDyPIDtysD
T728-p DGDyPIDtysDGLRP
Y729-p GDyPIDtysDGLRPP
S730-p DyPIDtysDGLRPPY
  rat

 
T14 IEQPIKVTEWQQTYT
T19 KVTEWQQTYTYDSGI
Y20 VTEWQQTYTYDSGIH
T21 TEWQQTYTYDSGIHS
Y22 EWQQTYTYDSGIHSG
S24 QQTYTYDSGIHSGVN
K40 CVPSVSSKGLLDEDD
Y53 DDTCGRQYTLKKTTT
T54 DTCGRQYTLKKTTTY
K56 CGRQYTLKKTTTYTQ
K57 GRQYTLKKTTTYTQG
T58 RQYTLKKTTTYTQGV
T59 QYTLKKTTTYTQGVP
T60 YTLKKTTTYTQGVPQ
Y61 TLKKTTTYTQGVPQS
T62 LKKTTTYTQGVPQSQ
S68 YTQGVPQSQGDLEYQ
Y74 QSQGDLEYQMSTTAR
S77 GDLEYQMSTTARAKR
S99 GVSGEDSSLLLATQV
S120 LQRLAEPSQLLKSAI
K124 AEPSQLLKSAIVHLI
S125 EPSQLLKSAIVHLIN
Y133 AIVHLINYQDDAELA
T141 QDDAELATRALPELT
K149 RALPELTKLLNDEDP
T160 DEDPVVVTKAAMIVN
K161 EDPVVVTKAAMIVNQ
K171 MIVNQLSKKEASRRA
S182-p SRRALMGsPQLVAAV
T196 VVRTMQNTSDLDTAR
T205 DLDTARCTTSILHNL
K224 EGLLAIFKSGGIPAL
K345 LSVCPSNKPAIVEAG
K385 NLSDVATKQEGLENV
T430 SKNKTLVTQNSGVEA
K448 AILRAGDKDDITEPA
T463 VCALRHLTSRHPEAE
Y480 QNSVRLNYGIPAIVK
K499 PNQWPLVKATIGLIR
Y550 AAGTQQPYTDGVRME
T551 AGTQQPYTDGVRMEE
S596 FVQLLYSSVENIQRV
Y644-p RNEGTATyAAAVLFR
Y660-p SEDKNPDyRKRVSVE
S665 PDyRKRVSVELTNSL
T669 KRVSVELTNSLFKHD
S671 VSVELTNSLFKHDPA
Y693-p MIPINEPyADDMDAT
Y701-p ADDMDATyRPMYSSD
Y724 HMDMDGDYPMDTYSD
T728 DGDYPMDTYSDGLRP
Y729 GDYPMDTYSDGLRPP
S730 DYPMDTYSDGLRPPY
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