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HS1 (mouse)

Overview HS1 Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS. Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54. Expressed only in tissues and cells of hematopoietic origin. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold Cellular Component: mitochondrion; cytoplasm; plasma membrane; nucleus Molecular Function: protein binding; protein complex binding; SH3 domain binding Biological Process: positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of cell proliferation; response to hormone stimulus; erythrocyte differentiation Reference #:  P49710 (UniProtKB) Alt. Names/Synonyms: AW213261; Hcls1; hematopoietic cell specific Lyn substrate 1; Hematopoietic cell-specific LYN substrate 1; Hematopoietic lineage cell-specific protein; Hs1; LckBP1 Gene Symbols: Hcls1 Molecular weight: 54,240 Da Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HS1

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	Sites Implicated In
intracellular localization: Y388‑p, Y405‑p molecular association, regulation: Y388‑p, Y405‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	0		T16	DVSVSVETQGDDWDT
1	13		T23	TQGDDWDTDPDFVND
0	2		S32	PDFVNDISEKEQRWG
0	1		K34	FVNDISEKEQRWGAK
0	1		K41	KEQRWGAKTIEGSGR
0	8		T42	EQRWGAKTIEGSGRT
0	1		K60	NIHQLRNKVSEEHDI
0	4		Y83	GPKASHGYGGRFGVE
0	1		S97	ERDRMDKSAVGHEyV
0	133		Y103-p	KSAVGHEyVADVEKH
0	1		K123	AARGFGGKYGVERDR
0	26		Y124	ARGFGGKYGVERDRA
0	3		S134	ERDRADKSAVGFDyK
0	97		Y140-p	KSAVGFDyKGEVEKH
0	1		K141	SAVGFDyKGEVEKHA
0	12		Y153-p	KHASQKDySHGFGGR
0	6		S154	HASQKDySHGFGGRY
0	3		Y161	SHGFGGRYGVEKDKR
0	165		Y175-p	RDKAALGyDyKGETE
0	118		Y177-p	KAALGyDyKGETEKH
0	1		T181	GyDyKGETEKHESQR
0	1		S186	GETEKHESQRdYAKG
0	1		D189-ca	EKHESQRdYAKGFGG
0	56		Y190	KHESQRdYAKGFGGQ
0	1		K192	ESQRdYAKGFGGQyG
0	276		Y198-p	AKGFGGQyGIQKDRV
0	2		S208	QKDRVDKSAVGFNEM
3	141		Y222-p	MEAPTTAyKKTTPIE
0	2		K223	EAPTTAyKKTTPIEA
0	1		K224	APTTAyKKTTPIEAA
0	1		K239	SSGARGLKAKFESLA
0	1		K241	GARGLKAKFESLAEE
0	26		S275	RKAVVKMSREVQQPS
0	4		S308	EVWPPAESHLPPESQ
0	5		Y323-p	PVRSRREyPVPsLPt
0	1		S327-p	RREyPVPsLPtRQsP
0	1		T330-p	yPVPsLPtRQsPLQN
0	4		S333-p	PsLPtRQsPLQNHLE
0	20		Y364-p	QVVEEPVyEAAPELE
0	1		T384-p	DYEPEPEtEPDyEDV
7	39		Y388-p	EPEtEPDyEDVGELD
8	9		Y405-p	DEDAEGDyEDVLEPE
0	3		Y482	FGLFPANYVKLL___

	human
T16-p	DVSVSVEtQGDDWDt
T23-p	tQGDDWDtDPDFVND
S32-p	PDFVNDIsEkEQRWG
K34-u	FVNDIsEkEQRWGAk
K41-a	kEQRWGAktIEGSGR
T42-p	EQRWGAktIEGSGRT
K60-u	NIHQLRNkVSEEHDV
Y83-p	GPKASHGyGGRFGVE
S97-p	ERDRMDKsAVGHEyV
Y103-p	KsAVGHEyVAEVEKH
K123-a	AAKGFGGkyGVERDR
Y124-p	AKGFGGkyGVERDRA
S134-p	ERDRADKsAVGFDyk
Y140-p	KsAVGFDykGEVEKH
K141-a	sAVGFDykGEVEKHT
Y153-p	KHTSQKDysRGFGGR
S154-p	HTSQKDysRGFGGRy
Y161-p	sRGFGGRyGVEKDKW
Y175-p	WDKAALGyDyKGEtE
Y177-p	KAALGyDyKGEtEKH
T181-p	GyDyKGEtEKHEsQR
S186-p	GEtEKHEsQRDyAkG
D189	EKHEsQRDyAkGFGG
Y190-p	KHEsQRDyAkGFGGQ
K192-a	EsQRDyAkGFGGQyG
Y198-p	AkGFGGQyGIQKDRV
S208-p	QKDRVDKsAVGFNEM
Y222-p	MEAPTTAykkTTPIE
K223-a	EAPTTAykkTTPIEA
K224-a	APTTAykkTTPIEAA
K239-u	SSGTRGLkAkFESMA
K241-a	GTRGLkAkFESMAEE
S275-p	RKAVTKRsPEAPQPV
T308-p	EAWPPVGtPPSSESE
H323	PVRTSREHPVPLLPI
L327	SREHPVPLLPIRQtL
I330	HPVPLLPIRQtLPED
T333-p	PLLPIRQtLPEDNEE
Y360-p	QVEEEPVyEAEPEPE
P374	EPEPEPEPENDyEDV
Y378-p	EPEPENDyEDVEEMD
Y397-p	EDEPEGDyEEVLEPE
Y481-p	FGLFPANyVKLLE__

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