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Protein Page:
DLG3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DLG3 Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: extracellular space; tight junction; growth cone; cell soma; cytoplasm; plasma membrane; synapse; dendritic shaft
Molecular Function: protein C-terminus binding; ionotropic glutamate receptor binding; protein binding; ubiquitin protein ligase binding; protein phosphatase binding; PDZ domain binding; phosphatase binding
Biological Process: establishment and/or maintenance of epithelial cell polarity; axon guidance; negative regulation of cell proliferation; synaptic transmission; establishment of planar polarity
Reference #:  Q92796 (UniProtKB)
Alt. Names/Synonyms: discs, large homolog 3 (Drosophila); Disks large homolog 3; DLG3; KIAA1232; MRX; MRX90; NEDLG; Neuroendocrine-DLG; SAP-102; SAP102; Synapse-associated protein 102; XLMR
Gene Symbols: DLG3
Molecular weight: 90,314 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DLG3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 14 Y14 CCKCPECYEVTRLAA
0 1 T78-p TKAKLIPtGRDVGPV
0 1 T95 KPVPGKSTPKLNGSG
0 1 T112-p WWPECTCtNRDWyEQ
0 1 Y117-p TCtNRDWyEQVNGsD
0 1 S123-p WyEQVNGsDGMFKYE
0 3 S139 IVLERGNSGLGFSIA
0 1 T163-p DDPGIFItKIIPGGA
0 18 K268 IEGGAAQKDGRLQIG
0 18 Y306-p KNTSDMVyLKVAKPG
0 1 - gap
0 1 S458-p ALKRAGQsVTIVAQY
0 3 S487-p LREQMMNssMssGSG
0 1 S488-p REQMMNssMssGSGS
0 1 S490-p QMMNssMssGSGSLR
0 1 S491-p MMNssMssGSGSLRT
0 1 S493 NssMssGSGSLRTSE
0 1 S495 sMssGSGSLRTSEKR
0 1 T515 ALFDYDRTRDSCLPS
0 1 S539 ILHVINASDDEWWQA
0 1 S563 EQIGVIPSKKRVEKK
0 1 T584 TVKFHARTGMIESNR
0 2 S597 NRDFPGLSDDYYGAK
0 16 Y600 FPGLSDDYYGAKNLK
0 10 Y601 PGLSDDYYGAKNLKG
0 1 - gap
0 2 - gap
0 1 - gap
0 4 - gap
0 7 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 1 - gap
0 1 Y626-p VTRQEIHyARPVIIL
0 1 T660-p GSCVPHTtRPRRDNE
0 1014 Y673-p NEVDGQDyHFVVsRE
0 19 S678-p QDyHFVVsREQMEKD
0 32 T759-p MEMNRRQtyEQANkI
0 3 Y760-p EMNRRQtyEQANkIY
0 1 K765-ac QtyEQANkIYDKAMK
0 35 Y808-p IEDQSGHyIWVPSPE
  DLG3 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K6-ub __MERARkFSGSGLA
S121 ALKRAGQSVTIVAQY
S150 LREQMMNSSMSSGSG
S151 REQMMNSSMSSGSGS
S153 QMMNSSMSSGSGSLR
S154 MMNSSMSSGSGSLRT
S156 NSSMSSGSGSLRTSE
S158 SMSSGSGSLRTSEKR
T178 ALFDYDRTRDSCLPS
S202 ILHVINASDDEWWQA
S226 EQIGVIPSKKRVEKK
T247 TVKFHARTGMIESNR
- gap
- gap
- gap
S255-p GMIESNRsIKTKRkK
K261-m1 RsIKTKRkKsFRLSR
K261-m3 RsIKTKRkKsFRLSR
K261-ub RsIKTKRkKsFRLSR
S263-p IKTKRkKsFRLSRKF
K276-ub KFPFYKSkENMAQEs
S283-p kENMAQEssIQEQGV
S284-p ENMAQEssIQEQGVT
T294-p EQGVTSNtSDSESSS
S295 QGVTSNtSDSESSSK
S299 SNtSDSESSSKGQED
Y321 VTRQEIHYARPVIIL
T355 GSCVPHTTRPRRDNE
Y368-p NEVDGQDyHFVVSRE
S373 QDyHFVVSREQMEKD
T454-p MEMNRRQtYEQANKI
Y455 EMNRRQtYEQANKIY
K460 QtYEQANKIYDKAMK
Y503-p IEDQSGHyIWVPSPE
  mouse

► Hide Isoforms
 
Y14 CCKCPECYEVTRLAA
T78 TKAKLIPTGRDVGPV
T95-p KPVPGKStPKLNGSG
T112 WWPECTCTNRDWYEQ
Y117 TCTNRDWYEQASPAP
S141 PSLSVNGSDGMFKYE
S157-p IVLERGNsGLGFSIA
T181 DDPGIFITKIIPGGA
K286-ub IEGGAAQkDGRLQIG
Y324-p KNTSDMVyLKVAKPG
- gap
S476 ALKRAGQSVTIVAQY
S505-p LREQMMNsSMSSGsG
S506 REQMMNsSMSSGsGs
S508 QMMNsSMSSGsGsLR
S509 MMNsSMSSGsGsLRT
S511-p NsSMSSGsGsLRTSE
S513-p SMSSGsGsLRTSEKR
T533-p ALFDYDRtRDSCLPS
S557-p ILHVINAsDDEWWQA
S581-p EQIGVIPsKKRVEKK
T602 TVKFHARTGMIESNR
S615-p NRDFPGLsDDYYGAK
Y618 FPGLsDDYYGAKNLK
Y619 PGLsDDYYGAKNLKG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T631 LKGVTSNTsDSEsSS
S632-p KGVTSNTsDSEsSSK
S636-p SNTsDSEsSSKGQED
Y658 VTRQEIHYARPVIIL
T692 GSCVPHTTRPRRDNE
Y705-p NEVDGQDyHFVVSRE
S710 QDyHFVVSREQMEKD
T791 MEMNRRQTYEQANKI
Y792 EMNRRQTYEQANKIF
K797 QTYEQANKIFDKAMK
Y840 IEDQSGHYIWVPSPE
  DLG3 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K6 __METARKFSGSSLA
S121 ALKRAGQSVTIVAQY
S150 LREQMMNSSMSSGSG
S151 REQMMNSSMSSGSGS
S153 QMMNSSMSSGSGSLR
S154 MMNSSMSSGSGSLRT
S156 NSSMSSGSGSLRTSE
S158 SMSSGSGSLRTSEKR
T178 ALFDYDRTRDSCLPS
S202 ILHVINASDDEWWQA
S226 EQIGVIPSKKRVEKK
T247 TVKFHARTGMIESNR
- gap
- gap
- gap
S255 GMIESNRSIKTKRkK
K261 RSIKTKRKKSFRLSR
K261 RSIKTKRKKSFRLSR
K261-ub RSIKTKRkKSFRLSR
S263 IKTKRkKSFRLSRKF
K276 KFPFYKSKENMAQEN
N283 KENMAQENSIQEQGV
S284 ENMAQENSIQEQGVT
T294 EQGVTSNTsDSESSS
S295-p QGVTSNTsDSESSSK
S299 SNTsDSESSSKGQED
Y321 VTRQEIHYARPVIIL
T355 GSCVPHTTRPRRDNE
Y368 NEVDGQDYHFVVSRE
S373 QDYHFVVSREQMEKD
T454 MEMNRRQTYEQANKI
Y455 EMNRRQTYEQANKIF
K460 QTYEQANKIFDKAMK
Y503 IEDQSGHYIWVPSPE
  rat

 
Y14-p CCKCPECyEVTRLAA
T78 TKAKLIPTGRDVGPV
T95 KPVPGKNTPKLNGSG
T112 WWPECTCTNRDWYEQ
Y117 TCTNRDWYEQASPAP
S141 PSLSVNGSDGMFKYE
S157 IVLERGNSGLGFSIA
T181 DDPGIFITKIIPGGA
K286-ub IEGGAAQkDGRLQIG
Y324-p KNTSDMVyLKVAKPG
- gap
S476 ALKRAGQSVTIVAQY
S505 LREQMMNSSMSSGSG
S506 REQMMNSSMSSGSGS
S508 QMMNSSMSSGSGSLR
S509 MMNSSMSSGSGSLRT
S511 NSSMSSGSGSLRTSE
S513 SMSSGSGSLRTSEKR
T533 ALFDYDRTRDSCLPS
S557 ILHVINASDDEWWQA
S581 EQIGVIPSKKRVEKK
T602-p TVKFHARtGMIESNR
S615-p NRDFPGLsDDyyGAK
Y618-p FPGLsDDyyGAKNLK
Y619-p PGLsDDyyGAKNLKG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T631 LKGVTSNTSDSESSS
S632 KGVTSNTSDSESSSK
S636 SNTSDSESSSKGQED
Y658 VTRQEIHYARPVIIL
T692 GSCVPHTTRPRRDNE
Y705-p NEVDGQDyHFVVSRE
S710 QDyHFVVSREQMEKD
T791 MEMNRRQTYEQANKI
Y792 EMNRRQTYEQANKIF
K797 QTYEQANKIFDKAMK
Y840 IEDQSGHYIWVPSPE
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