Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ARPP-19 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARPP-19 a protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at S62 by MASTL during mitosis, specifically interacts with PPP2R2D and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP43 expression. Interacts with SNCA. Two isoforms of the human protein, ARPP-19 and ARPP-16, are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Phosphatase, regulatory subunit
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: phosphatase inhibitor activity; potassium channel regulator activity; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity; protein phosphatase inhibitor activity; receptor binding
Biological Process: mitosis; positive regulation of glucose import; positive regulation of gluconeogenesis; regulation of catalytic activity; negative regulation of catalytic activity; mitotic cell cycle; G2/M transition of mitotic cell cycle
Reference #:  P56211 (UniProtKB)
Alt. Names/Synonyms: ARP19; ARPP-16; ARPP-19; ARPP16; ARPP19; cAMP-regulated phosphoprotein 19; cAMP-regulated phosphoprotein, 19kDa; cyclic AMP phosphoprotein, 19 kD; endosulfine alpha-like; ENSAL; FLJ41622
Gene Symbols: ARPP19
Molecular weight: 12,323 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Select Structure to View Below

ARPP-19

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsAEVPEAA
0 1 S10 AEVPEAASAEEQKEM
0 1 T22-p KEMEDKVtsPEkAEE
0 11 S23-p EMEDKVtsPEkAEEA
0 4 K26-ac DKVtsPEkAEEAkLk
0 3 K31-ac PEkAEEAkLkARyPH
0 1 K33-ac kAEEAkLkARyPHLG
0 22 Y36-p EAkLkARyPHLGQkP
0 2 K42-ac RyPHLGQkPGGSDFL
0 13 K58-ac KRLQKGQkyFDsGDy
0 2 K58-ub KRLQKGQkyFDsGDy
0 319 Y59-p RLQKGQkyFDsGDyN
0 79 S62-p KGQkyFDsGDyNMAk
0 533 Y65-p kyFDsGDyNMAkAkM
0 3 K69-ub sGDyNMAkAkMKNKQ
0 1 K71-ub DyNMAkAkMKNKQLP
0 1 T79-p MKNKQLPtAAPDkTE
0 1 K84-ac LPtAAPDkTEVTGDH
0 2 T94-p VTGDHIPtPQDLPQR
1 103 S104-p DLPQRKPsLVAskLA
0 6 S108-p RKPsLVAskLAG___
0 1 K109-ac KPsLVAskLAG____
5240 : Phospho-ENSA (Ser67)/ARPP19 (Ser62) Antibody
  mouse

 
S2 ______MSAEVPEAA
S10-p AEVPEAAsAEEQKEM
T22-p KEMEDKVtsPEKAEE
S23-p EMEDKVtsPEKAEEA
K26 DKVtsPEKAEEAKLK
K31 PEKAEEAKLKARYPH
K33 KAEEAKLKARYPHLG
Y36 EAKLKARYPHLGQKP
K42 RYPHLGQKPGGSDFL
K58-ac KRLQKGQkyFDsGDy
K58-ub KRLQKGQkyFDsGDy
Y59-p RLQKGQkyFDsGDyN
S62-p KGQkyFDsGDyNMAK
Y65-p kyFDsGDyNMAKAKM
K69 sGDyNMAKAKMKNKQ
K71 DyNMAKAKMKNKQLP
A79 MKNKQLPAAAPDKTE
K84 LPAAAPDKTEVTGDH
T94 VTGDHIPTPQDLPQR
S104-p DLPQRKPsLVAsKLA
S108-p RKPsLVAsKLAG___
K109 KPsLVAsKLAG____
5240 : Phospho-ENSA (Ser67)/ARPP19 (Ser62) Antibody
  rat

 
S2 ______MSAEVPEAA
S10 AEVPEAASAEEQKEM
T22 KEMEDKVTSPEKAEE
S23 EMEDKVTSPEKAEEA
K26 DKVTSPEKAEEAKLK
K31 PEKAEEAKLKARYPH
K33 KAEEAKLKARYPHLG
Y36 EAKLKARYPHLGQKP
K42 RYPHLGQKPGGSDFL
K58 KRLQKGQKyFDsGDy
K58 KRLQKGQKyFDsGDy
Y59-p RLQKGQKyFDsGDyN
S62-p KGQKyFDsGDyNMAK
Y65-p KyFDsGDyNMAKAKM
K69 sGDyNMAKAKMKNKQ
K71 DyNMAKAKMKNKQLP
A79 MKNKQLPAAAPDKTE
K84 LPAAAPDKTEVTGDH
T94 VTGDHIPTPQDLPQR
S104-p DLPQRKPsLVASKLA
S108 RKPsLVASKLAG___
K109 KPsLVASKLAG____
5240 : Phospho-ENSA (Ser67)/ARPP19 (Ser62) Antibody
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.