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ARPP-19 (human)

Overview ARPP-19 a cytoplasmic, highly conserved cAMP-regulated phosphoprotein (ARPP). An RNA binding phosphoprotein that can regulate mRNA stability. Two alternatively spliced isoforms (ARPP-19 and ARPP-16) have been described. ARPP-19 is ubiquitously expressed. ARPP-16 appears in the brain at the end of the first post-natal week and is enriched in dopamine-responsive medium spiny neurons in the striatum. The phosphorylation of ARPP-16 was increased in response to activation of D(1)-dopamine receptors, and decreased in response to activation of D(2)-dopamine receptors in striatal neurons. ARPP-16 may play a specific role in dopamine-dependent signal transduction. Note: This description may include information from UniProtKB. Protein type: GTPase activating protein, Ras; RNA binding protein Cellular Component: cytoplasm Molecular Function: phosphatase inhibitor activity; potassium channel regulator activity; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity; protein phosphatase inhibitor activity; receptor binding Biological Process: positive regulation of gluconeogenesis; mitosis; positive regulation of glucose import; cell division; G2/M transition of mitotic cell cycle Reference #:  P56211 (UniProtKB) Alt. Names/Synonyms: ARP19; ARPP-16; ARPP-19; ARPP16; ARPP19; cAMP-regulated phosphoprotein 19; cAMP-regulated phosphoprotein, 19kDa; cyclic AMP phosphoprotein, 19 kD; endosulfine alpha-like; ENSAL; FLJ41622 Gene Symbols: ARPP19 Molecular weight: 12,323 Da Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states

Select Structure to View Below ARPP-19

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S10	AEVPEAASAEEQKEM
0	8		S23-p	EMEDKVTsPEkAEEA
0	4		K26-a	DKVTsPEkAEEAkLk
0	3		K31-a	PEkAEEAkLkARyPH
0	1		K33-a	kAEEAkLkARyPHLG
0	12		Y36-p	EAkLkARyPHLGQkP
0	2		K42-a	RyPHLGQkPGGSDFL
0	12		K58-a	KRLQKGQkyFDsGDy
0	2		K58-u	KRLQKGQkyFDsGDy
0	332		Y59-p	RLQKGQkyFDsGDyN
0	68		S62-p	KGQkyFDsGDyNMAk
0	548		Y65-p	kyFDsGDyNMAkAkM
0	3		K69-u	sGDyNMAkAkMKNKQ
0	1		K71-u	DyNMAkAkMKNKQLP
0	1		T79-p	MKNKQLPtAAPDKTE
0	2		T94-p	VTGDHIPtPQDLPQR
1	96		S104-p	DLPQRKPsLVAskLA
0	5		S108-p	RKPsLVAskLAG___
0	1		K109-a	KPsLVAskLAG____

	mouse
S10-p	AEVPEAAsAEEQKEM
S23-p	EMEDKVTsPEKAEEA
K26	DKVTsPEKAEEAKLK
K31	PEKAEEAKLKARYPH
K33	KAEEAKLKARYPHLG
Y36	EAKLKARYPHLGQKP
K42	RYPHLGQKPGGSDFL
K58-a	KRLQKGQkyFDsGDy
K58-u	KRLQKGQkyFDsGDy
Y59-p	RLQKGQkyFDsGDyN
S62-p	KGQkyFDsGDyNMAK
Y65-p	kyFDsGDyNMAKAKM
K69	sGDyNMAKAKMKNKQ
K71	DyNMAKAKMKNKQLP
A79	MKNKQLPAAAPDKTE
T94	VTGDHIPTPQDLPQR
S104-p	DLPQRKPsLVAsKLA
S108-p	RKPsLVAsKLAG___
K109	KPsLVAsKLAG____

	rat
S10	AEVPEAASAEEQKEM
S23	EMEDKVTSPEKAEEA
K26	DKVTSPEKAEEAKLK
K31	PEKAEEAKLKARYPH
K33	KAEEAKLKARYPHLG
Y36	EAKLKARYPHLGQKP
K42	RYPHLGQKPGGSDFL
K58	KRLQKGQKyFDsGDy
K58	KRLQKGQKyFDsGDy
Y59-p	RLQKGQKyFDsGDyN
S62-p	KGQKyFDsGDyNMAK
Y65-p	KyFDsGDyNMAKAKM
K69	sGDyNMAKAKMKNKQ
K71	DyNMAKAKMKNKQLP
A79	MKNKQLPAAAPDKTE
T94	VTGDHIPTPQDLPQR
S104-p	DLPQRKPsLVASKLA
S108	RKPsLVASKLAG___
K109	KPsLVASKLAG____

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