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desmoplakin 3
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis |
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Cellular Component: desmosome; internal side of plasma membrane; basolateral plasma membrane; apicolateral plasma membrane; fascia adherens; intercellular junction; catenin complex; zonula adherens; cytosol; Z disc; actin cytoskeleton; transcription factor complex; cell-cell adherens junction; cytoskeleton; hemidesmosome; cytoplasm; plasma membrane; nucleus; lateral plasma membrane
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Molecular Function: protein binding; protein homodimerization activity; structural constituent of cell wall; cadherin binding; transcription coactivator activity; structural molecule activity; protein kinase binding; protein phosphatase binding; alpha-catenin binding
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Biological Process: skin development; intercellular junction assembly and maintenance; nervous system development; cell migration; cytoskeletal anchoring; cell morphogenesis; detection of mechanical stimulus; gastrulation; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of apoptosis; cell-cell adhesion; morphogenesis of embryonic epithelium; positive regulation of protein import into nucleus; ectoderm development; positive regulation of transcription factor activity; oocyte development
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Reference #:
P14923 (UniProtKB)
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| Alt. Names/Synonyms: ARVD12; catenin (cadherin-associated protein), gamma (80kD); catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; gamma-catenin; Junction plakoglobin; JUP; PDGB; PKGB; PLAK |
| Gene Symbols: JUP |
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Molecular weight: 81,745 Da
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Basal Isoelectric point: 5.75
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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