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Protein Page:
Desmoplakin-3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Desmoplakin-3 Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: desmosome; internal side of plasma membrane; basolateral plasma membrane; apicolateral plasma membrane; intermediate filament; fascia adherens; zonula adherens; intercellular junction; catenin complex; Z disc; cytosol; actin cytoskeleton; transcription factor complex; cell-cell adherens junction; cytoskeleton; hemidesmosome; cytoplasm; plasma membrane; nucleus; lateral plasma membrane
Molecular Function: protein binding; protein homodimerization activity; structural constituent of cell wall; cadherin binding; transcription coactivator activity; structural molecule activity; protein phosphatase binding; protein kinase binding; alpha-catenin binding
Biological Process: skin development; nervous system development; intercellular junction assembly and maintenance; cell migration; cytoskeletal anchoring; protein heterooligomerization; cell morphogenesis; detection of mechanical stimulus; gastrulation; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; cell-cell adhesion; morphogenesis of embryonic epithelium; positive regulation of protein import into nucleus; ectoderm development; positive regulation of transcription factor activity; oocyte development
Reference #:  P14923 (UniProtKB)
Alt. Names/Synonyms: ARVD12; catenin (cadherin-associated protein), gamma (80kD); catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; gamma-catenin; Junction plakoglobin; JUP; PDGB; PKGB; PLAK
Gene Symbols: JUP
Molecular weight: 81,745 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Desmoplakin-3

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: Y133‑p, Y550‑p, Y644‑p
molecular association, regulation: Y133‑p, Y550‑p, Y644‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T14-gl MEQPIKVtEWQQTyt
0 125 Y20-p VtEWQQTytyDSGIH
0 8 T21-p tEWQQTytyDSGIHS
0 53 Y22-p EWQQTytyDSGIHSG
0 1 K40-u CVPSVSSkGIMEEDE
0 13 Y53-p DEACGRQytLKKttt
0 26 T54-p EACGRQytLKKttty
0 1 K57 GRQytLKKtttytQG
0 3 T58-p RQytLKKtttytQGV
0 2 T59-p QytLKKtttytQGVP
0 3 T60-p ytLKKtttytQGVPP
0 8 Y61-p tLKKtttytQGVPPs
0 2 T62-p LKKtttytQGVPPsQ
0 10 S68-p ytQGVPPsQGDLEyQ
0 115 Y74-p PsQGDLEyQMsTTAR
0 1 S77-p GDLEyQMsTTARAKR
0 1 S120-p LQRLAEPsQLLkSAI
0 3 K124-u AEPsQLLkSAIVHLI
1 1 Y133-p AIVHLINyQDDAELA
0 1 T141-p QDDAELAtRALPELT
0 1 K149-u RALPELTkLLNDEDP
0 2 K161-u EDPVVVTkAAMIVNQ
0 1 K171 MIVNQLSKKEASRRA
0 11 S182-p SRRALMGsPQLVAAV
0 7 T196-p VVRTMQNtSDLDTAR
0 3 K224-u EGLLAIFkSGGIPAL
0 1 K385-u NLSDVATkQEGLESV
0 1 T430-p SKNKTLVtQNSGVEA
0 1 K448 AILRAGDKDDITEPA
0 1 T463-p VCALRHLtSRHPEAE
0 101 Y480-p QNSVRLNyGIPAIVK
0 8 K499-u PNQWPLVkATIGLIR
1 141 Y550-p AAGTQQPyTDGVRME
0 1 S596-p FVQLLYSsVENIQRV
1 28 Y644-p RNEGTATyAAAVLFR
0 143 Y660-p SEDKNPDyRKRVsVE
0 11 S665-p PDyRKRVsVELTNSL
0 1 S671 VsVELTNSLFKHDPA
0 4 Y701-p GDDMDATyRPMYSSD
0 5 Y724-p HMDMDGDyPIDtySD
0 2 T728-p DGDyPIDtySDGLRP
0 4 Y729-p GDyPIDtySDGLRPP
  mouse

 
T14 IEQPIKVTEWQQTYT
Y20 VTEWQQTYTYDSGIH
T21 TEWQQTYTYDSGIHS
Y22 EWQQTYTYDSGIHSG
K40 CVPSVSSKGIMDEDD
Y53-p DDACGRQytLKkTTT
T54-p DACGRQytLKkTTTY
K57-u GRQytLKkTTTYTQG
T58 RQytLKkTTTYTQGV
T59 QytLKkTTTYTQGVP
T60 ytLKkTTTYTQGVPQ
Y61 tLKkTTTYTQGVPQN
T62 LKkTTTYTQGVPQNQ
N68 YTQGVPQNQGDLEYQ
Y74 QNQGDLEYQMsTTAR
S77-p GDLEYQMsTTARAKR
S120 LQRLAEPSQLLkSAI
K124-u AEPSQLLkSAIVHLI
Y133 AIVHLINYQDDAELA
T141 QDDAELATRALPELT
K149 RALPELTKLLNDEDP
K161 EDPVVVTKAAMIVNQ
K171-u MIVNQLSkKEASRRA
S182-p SRRALMGsPQLVAAV
T196 VVRTMQNTSDLDTAR
K224-u EGLLAIFkSGGIPAL
K385 NLSDVATKQEGLESV
T430 SKNKTLVTQNSGVEA
K448-u AILRAGDkDDITEPA
T463 VCALRHLTSRHPEAE
Y480-p QNSVRLNyGIPAIVK
K499 PNQWPLVKATIGLIR
Y550 AAGTQQPYTDGVRME
S596 FVQLLYSSVENIQRV
Y644 RNEGTATYAAAVLFR
Y660 SEDKNPDYRKRVsVE
S665-p PDYRKRVsVELTNsL
S671-p VsVELTNsLFKHDPA
Y701 ADDMDATYRPMYSSD
Y724 HMDLDGDYPMDTYSD
T728 DGDYPMDTYSDGLRP
Y729 GDYPMDTYSDGLRPP
  rat

 
T14 IEQPIKVTEWQQTYT
Y20 VTEWQQTYTYDSGIH
T21 TEWQQTYTYDSGIHS
Y22 EWQQTYTYDSGIHSG
K40 CVPSVSSKGLLDEDD
Y53 DDTCGRQYTLKKTTT
T54 DTCGRQYTLKKTTTY
K57 GRQYTLKKTTTYTQG
T58 RQYTLKKTTTYTQGV
T59 QYTLKKTTTYTQGVP
T60 YTLKKTTTYTQGVPQ
Y61 TLKKTTTYTQGVPQS
T62 LKKTTTYTQGVPQSQ
S68 YTQGVPQSQGDLEYQ
Y74 QSQGDLEYQMSTTAR
S77 GDLEYQMSTTARAKR
S120 LQRLAEPSQLLKSAI
K124 AEPSQLLKSAIVHLI
Y133 AIVHLINYQDDAELA
T141 QDDAELATRALPELT
K149 RALPELTKLLNDEDP
K161 EDPVVVTKAAMIVNQ
K171 MIVNQLSKKEASRRA
S182-p SRRALMGsPQLVAAV
T196 VVRTMQNTSDLDTAR
K224 EGLLAIFKSGGIPAL
K385 NLSDVATKQEGLENV
T430 SKNKTLVTQNSGVEA
K448 AILRAGDKDDITEPA
T463 VCALRHLTSRHPEAE
Y480 QNSVRLNYGIPAIVK
K499 PNQWPLVKATIGLIR
Y550 AAGTQQPYTDGVRME
S596 FVQLLYSSVENIQRV
Y644-p RNEGTATyAAAVLFR
Y660-p SEDKNPDyRKRVSVE
S665 PDyRKRVSVELTNSL
S671 VSVELTNSLFKHDPA
Y701-p ADDMDATyRPMYSSD
Y724 HMDMDGDYPMDTYSD
T728 DGDYPMDTYSDGLRP
Y729 GDYPMDTYSDGLRPP
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