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ENSA (human)

Overview ENSA a cytoplasmic, highly conserved cAMP-regulated phosphoprotein (ARPP) and regulator of ATP-sensitive potassium (KATP) channels. An endogenous ligand for the sulfonylurea receptor, ABCC8, the regulatory subunit of the KATP channel located on the plasma membrane of pancreatic beta cells. Modulates insulin secretion through the interaction with ABCC8, and may be associated with type 2 diabetes. Eight alternatively spliced isoforms have been observed. Note: This description may include information from UniProtKB. Protein type: Inhibitor protein Cellular Component: cytoplasm Molecular Function: phosphatase inhibitor activity; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity; protein phosphatase inhibitor activity; ion channel inhibitor activity; receptor binding Biological Process: mitosis; cell division; transport; G2/M transition of mitotic cell cycle; response to nutrient Reference #:  O43768 (UniProtKB) Alt. Names/Synonyms: Alpha-endosulfine; ARPP-19e; endosulfine alpha; ENSA; MGC4319; MGC78563; MGC8394 Gene Symbols: ENSA Molecular weight: 13,389 Da Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ENSA

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	Sites Implicated In
molecular association, regulation: S109‑p protein conformation: S109‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	6		S2-p	______MsQKQEEEN
0	1		T14-p	EENPAEEtGEEKQDT
0	6		Y41-p	EAKLKAKyPsLGQKP
0	17		S43-p	KLKAKyPsLGQKPGG
0	2		S51-p	LGQKPGGsDFLMKRL
0	12		K63-a	KRLQKGQkyFDsGDy
0	2		K63-u	KRLQKGQkyFDsGDy
0	332		Y64-p	RLQKGQkyFDsGDyN
0	66		S67-p	KGQkyFDsGDyNMAk
0	547		Y70-p	kyFDsGDyNMAkAkM
0	3		K74-u	sGDyNMAkAkMKNKQ
0	1		K76-u	DyNMAkAkMKNKQLP
0	1		S84-p	MKNKQLPsAGPDKNL
0	2		T99-p	VTGDHIPtPQDLPQR
0	9		S108-p	QDLPQRKssLVTsKL
1	61		S109-p	DLPQRKssLVTsKLA
0	1		S113-p	RKssLVTsKLAGGQV

	mouse
S2-p	______MsQKQEEEN
T14	EENPAEETGEEKQDT
Y41	EAKLKAKYPsLGQKP
S43-p	KLKAKYPsLGQKPGG
S51	LGQKPGGSDFLMKRL
K63-a	KRLQKGQkyFDsGDy
K63-u	KRLQKGQkyFDsGDy
Y64-p	RLQKGQkyFDsGDyN
S67-p	KGQkyFDsGDyNMAK
Y70-p	kyFDsGDyNMAKAKM
K74	sGDyNMAKAKMKNKQ
K76	DyNMAKAKMKNKQLP
S84	MKNKQLPSAGADKNL
T99	VTGDHIPTPQDLPQR
S108-p	QDLPQRKssLVTSKL
S109-p	DLPQRKssLVTSKLA
S113	RKssLVTSKLAGGQV

	rat
S2	______MSQKQEEEN
T14	EENPAEETGEEKQDT
Y41	EAKLKAKYPSLGQKP
S43	KLKAKYPSLGQKPGG
S51	LGQKPGGSDFLMKRL
K63	KRLQKGQKyFDsGDy
K63	KRLQKGQKyFDsGDy
Y64-p	RLQKGQKyFDsGDyN
S67-p	KGQKyFDsGDyNMAK
Y70-p	KyFDsGDyNMAKAKM
K74	sGDyNMAKAKMKNKQ
K76	DyNMAKAKMKNKQLP
S84	MKNKQLPSAGADKNL
T99	VTGDHIPTPQDLPQR
S108	QDLPQRKSsLVTSKL
S109-p	DLPQRKSsLVTSKLA
S113	RKSsLVTSKLAGGQV

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