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Protein Page:
ENSA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ENSA a cytoplasmic, highly conserved cAMP-regulated phosphoprotein (ARPP) and regulator of ATP-sensitive potassium (KATP) channels. An endogenous ligand for the sulfonylurea receptor, ABCC8, the regulatory subunit of the KATP channel located on the plasma membrane of pancreatic beta cells. Modulates insulin secretion through the interaction with ABCC8, and may be associated with type 2 diabetes. Eight alternatively spliced isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: phosphatase inhibitor activity; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity; protein phosphatase inhibitor activity; potassium channel inhibitor activity; ion channel inhibitor activity; receptor binding
Biological Process: mitosis; regulation of catalytic activity; transport; negative regulation of catalytic activity; response to glucose stimulus; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of insulin secretion; response to nutrient
Reference #:  O43768 (UniProtKB)
Alt. Names/Synonyms: Alpha-endosulfine; ARPP-19e; endosulfine alpha; ENSA; MGC4319; MGC78563; MGC8394
Gene Symbols: ENSA
Molecular weight: 13,389 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ENSA

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S109‑p
protein conformation: S109‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 9 S2-p ______MsQKQEEEN
0 2 T14-p EENPAEEtGEEKQDt
0 1 T21-p tGEEKQDtQEKEGIL
0 7 Y41-p EAKLKAKyPsLGQkP
0 20 S43-p KLKAKyPsLGQkPGG
0 1 K47-ac KyPsLGQkPGGsDFL
0 2 S51-p LGQkPGGsDFLMKRL
0 1 - gap
0 13 K63-ac KRLQKGQkyFDsGDy
0 2 K63-ub KRLQKGQkyFDsGDy
0 320 Y64-p RLQKGQkyFDsGDyN
1 81 S67-p KGQkyFDsGDyNMAk
0 534 Y70-p kyFDsGDyNMAkAkM
0 3 K74-ub sGDyNMAkAkMKNKQ
0 1 K76-ub DyNMAkAkMKNKQLP
0 1 S84-p MKNKQLPsAGPDkNL
0 1 K89-ac LPsAGPDkNLVtGDH
0 1 T93-gl GPDkNLVtGDHIPtP
0 4 T99-p VtGDHIPtPQDLPQR
0 1 T99-gl VtGDHIPtPQDLPQR
0 10 S108-p QDLPQRKssLVtsKL
1 70 S109-p DLPQRKssLVtsKLA
0 2 T112-p QRKssLVtsKLAGGQ
0 3 S113-p RKssLVtsKLAGGQV
5240 : Phospho-ENSA (Ser67)/ARPP19 (Ser62) Antibody
  ENSA iso3  
S2 ______MSQKQEEEN
T14 EENPAEETGEEKQDT
T21 TGEEKQDTQEKEGIL
Y41 EAKLKAKYPSLGQKP
S43 KLKAKYPSLGQKPGG
K47 KYPSLGQKPGGSDFL
S51 LGQKPGGSDFLMKRL
Y63-p KRLQKGDyKSLHWSV
K79 LCADEMQKyFDsGDy
K79 LCADEMQKyFDsGDy
Y80-p CADEMQKyFDsGDyN
S83-p EMQKyFDsGDyNMAK
Y86-p KyFDsGDyNMAKAKM
K90 sGDyNMAKAKMKNKQ
K92 DyNMAKAKMKNKQLP
S100 MKNKQLPSAGPDKNL
K105 LPSAGPDKNLVTGDH
T109 GPDKNLVTGDHIPTP
T115 VTGDHIPTPQDLPQR
T115 VTGDHIPTPQDLPQR
S124 QDLPQRKSSLVTSKL
S125 DLPQRKSSLVTSKLA
T128 QRKSSLVTSKLAGGQ
S129 RKSSLVTSKLAGGQV
  mouse

 
S2-p ______MsQKQEEEN
T14 EENPAEETGEEKQDT
T21 TGEEKQDTQEKEGIL
Y41 EAKLKAKYPsLGQKP
S43-p KLKAKYPsLGQKPGG
K47 KYPsLGQKPGGSDFL
S51 LGQKPGGSDFLMKRL
- gap
K63-ac KRLQKGQkyFDsGDy
K63-ub KRLQKGQkyFDsGDy
Y64-p RLQKGQkyFDsGDyN
S67-p KGQkyFDsGDyNMAK
Y70-p kyFDsGDyNMAKAKM
K74 sGDyNMAKAKMKNKQ
K76 DyNMAKAKMKNKQLP
S84 MKNKQLPSAGADKNL
K89 LPSAGADKNLVTGDH
T93 GADKNLVTGDHIPTP
T99 VTGDHIPTPQDLPQR
T99 VTGDHIPTPQDLPQR
S108-p QDLPQRKssLVTsKL
S109-p DLPQRKssLVTsKLA
T112 QRKssLVTsKLAGGQ
S113-p RKssLVTsKLAGGQV
5240 : Phospho-ENSA (Ser67)/ARPP19 (Ser62) Antibody
  rat

 
S2-p ______MsQKQEEEN
T14 EENPAEETGEEKQDT
T21 TGEEKQDTQEKEGIL
Y41 EAKLKAKYPSLGQkP
S43 KLKAKYPSLGQkPGG
K47-ac KYPSLGQkPGGSDFL
S51 LGQkPGGSDFLMKRL
- gap
K63-ac KRLQKGQkyFDsGDy
K63 KRLQKGQKyFDsGDy
Y64-p RLQKGQkyFDsGDyN
S67-p KGQkyFDsGDyNMAK
Y70-p kyFDsGDyNMAKAKM
K74 sGDyNMAKAKMKNKQ
K76 DyNMAKAKMKNKQLP
S84 MKNKQLPSAGADKNL
K89 LPSAGADKNLVTGDH
T93 GADKNLVTGDHIPTP
T99 VTGDHIPTPQDLPQR
T99 VTGDHIPTPQDLPQR
S108 QDLPQRKSsLVTSKL
S109-p DLPQRKSsLVTSKLA
T112 QRKSsLVTSKLAGGQ
S113 RKSsLVTSKLAGGQV
5240 : Phospho-ENSA (Ser67)/ARPP19 (Ser62) Antibody
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