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Protein Page:
MIG-6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MIG-6 Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. Interacts with ERBB2. Interacts with EGFR. Levels are very low in quiescent cells. Up-regulated by mitogens. Belongs to the MIG6 family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein
Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; nucleus
Molecular Function: protein binding; Rho GTPase activator activity; protein kinase binding
Biological Process: negative regulation of epidermal growth factor receptor activity; skin morphogenesis; response to stress; negative regulation of protein amino acid autophosphorylation; alveolus development; regulation of keratinocyte differentiation; positive regulation of Rho GTPase activity
Reference #:  Q9UJM3 (UniProtKB)
Alt. Names/Synonyms: ERBB receptor feedback inhibitor 1; ERRFI; ERRFI1; GENE-33; MIG-6; MIG6; Mitogen-inducible gene 6 protein; RALT; receptor-associated late transducer
Gene Symbols: ERRFI1
Molecular weight: 50,560 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MIG-6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 7 Y33-p MGNMRKTyWSSRSEF
0 2 K116-ac DQVVCGFkKLTVNGV
0 2 A125 LTVNGVCAstPPLtP
0 6 S126-p TVNGVCAstPPLtPI
0 19 T127-p VNGVCAstPPLtPIK
0 11 T131-p CAstPPLtPIKNsPS
0 3 S136-p PLtPIKNsPSLFPCA
0 1 S138 tPIKNsPSLFPCAPL
0 1 S176-p CEVEFLTsSDTDFLL
0 1 Y193-p STLSDFKyDVPGRRS
0 1 Y224-p VSAADLSyVSDQNGG
2 5 S249-p THRRLRRsHsGPAGS
2 59 S251-p RRLRRsHsGPAGSFN
0 1 S256 sHsGPAGSFNKPAIR
0 1 I269 IRISNCCIHRAsPNs
1 5 S273-p NCCIHRAsPNsDEDK
0 1 N275 CIHRAsPNsDEDKPE
1 2 S276-p IHRAsPNsDEDKPEV
1 6 S302-p KPDYRRWsAEVTSST
1 2 S326-p VPPREPLsPSNSRTP
0 1 S328 PREPLsPSNSRTPsP
1 1 S334-p PSNSRTPsPKSLPSy
0 1 S340 PsPKSLPSyLNGVMP
0 11 Y341-p sPKSLPSyLNGVMPP
0 1 S351 GVMPPTQSFAPDPKy
0 3 Y358-p SFAPDPKyVSsKALQ
0 1 S361-p PDPKyVSsKALQRQN
0 9 N368 sKALQRQNsEGsAsK
1 36 S369-p KALQRQNsEGsAsKV
0 5 S372-p QRQNsEGsAsKVPCI
0 1 S374-p QNsEGsAsKVPCILP
1 5 S390-p IENGKKVsstHyyLL
1 6 S391-p ENGKKVsstHyyLLP
0 13 T392-p NGKKVsstHyyLLPE
1 244 Y394-p KKVsstHyyLLPERP
1 143 Y395-p KVsstHyyLLPERPP
0 8 Y403-p LLPERPPyLDKyEKF
0 11 Y407-p RPPyLDKyEKFFREA
0 2 S457-p HVKRKHLsyVVsP__
0 5 Y458-p VKRKHLsyVVsP___
0 7 S461-p KHLsyVVsP______
  mouse

 
C32 ALGNMKSCWGSHSEF
K115 DQVMCGFKKLSVNGV
T124-p LSVNGVCtstPPLtP
S125-p SVNGVCtstPPLtPI
T126-p VNGVCtstPPLtPIK
T130-p CtstPPLtPIKSCPs
C135 PLtPIKSCPsPFPCA
S137-p tPIKSCPsPFPCAAL
S176 EVELLTTSSDTDLLL
Y193 SAPSDFKYDAPGRRS
C224 VSVADLSCASDQNRV
S249 SHRRLRRSHsGPAGs
S251-p RRLRRSHsGPAGsFN
S256-p SHsGPAGsFNKPAIR
T268-p AIRISSCtHRAsPss
S272-p SSCtHRAsPssDEDK
S274-p CtHRAsPssDEDKPE
S275-p tHRAsPssDEDKPEV
S301-p KPDYRRWsAEVTSNT
S325 VPPREPLSRsNSRTP
S327-p PREPLSRsNSRTPsP
S333-p RsNSRTPsPKSLPSY
S339 PsPKSLPSYLNGVMP
Y340 sPKSLPSYLNGVMPP
S350 GVMPPTQSFAPDPKY
Y357 SFAPDPKYVSSKALQ
S360 PDPKYVSSKALQRQs
S367-p SKALQRQssEGsANK
S368-p KALQRQssEGsANKV
S371-p QRQssEGsANKVPCI
N373 QssEGsANKVPCILP
S389 IENGKKVSSTHyyLL
S390 ENGKKVSSTHyyLLP
T391 NGKKVSSTHyyLLPE
Y393-p KKVSSTHyyLLPERP
Y394-p KVSSTHyyLLPERPP
Y402 LLPERPPYLDKYEKY
Y406 RPPYLDKYEKYFKEA
S456 HGKRKHLSYVVsP__
Y457 GKRKHLSYVVsP___
S460-p KHLSYVVsP______
  rat

 
C32 ALGNMKTCWGSRNEF
K115 DQVLCGFKKLSVNGV
A124 LSVNGVCASTPPLTP
S125 SVNGVCASTPPLTPI
T126 VNGVCASTPPLTPIQ
T130 CASTPPLTPIQSCSS
C135 PLTPIQSCSSPFPCA
S137 TPIQSCSSPFPCAAP
S175 CEVEFLTSADTDFLL
Y192 CVPSDFKYDVPGRRS
C223 VSVADLSCASDQNRV
S248-p SHRRLRRsHsGPAGS
S250-p RRLRRsHsGPAGSFN
S255 sHsGPAGSFNKPAIR
T267 AIRISSCTHRASPSS
S271 SSCTHRASPSSDEDK
S273 CTHRASPSSDEDKPE
S274 THRASPSSDEDKPEI
S300 KPDYRRWSAEVTSNT
S324 VPPREPLSRSNSRTP
S326 PREPLSRSNSRTPSP
S332 RSNSRTPSPKSLPsY
S338-p PSPKSLPsYLNGVMP
Y339 SPKSLPsYLNGVMPP
S349-p GVMPPTQsFAPDPKY
Y356 sFAPDPKYVSSKALQ
S359 PDPKYVSSKALQRQS
S366 SKALQRQSSEGSAKA
S367 KALQRQSSEGSAKAP
S370 QRQSSEGSAKAPCIL
- under review  
S387-p IENGKKVssTHYYLL
S388-p ENGKKVssTHYYLLP
T389 NGKKVssTHYYLLPE
Y391 KKVssTHYYLLPERP
Y392 KVssTHYYLLPERPP
Y400 LLPERPPYLDKYEKY
Y404 RPPYLDKYEKYFREA
S454 HGKRKHLSYVVSP__
Y455 GKRKHLSYVVSP___
S458 KHLSYVVSP______
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