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Protein Page:
p63 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
p63 Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Belongs to the p53 family. 12 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; dendrite; cytoplasm; nuclear chromatin; nucleolus; cytosol; nucleus; chromatin
Molecular Function: identical protein binding; protein binding; DNA binding; sequence-specific DNA binding; p53 binding; metal ion binding; double-stranded DNA binding; WW domain binding; damaged DNA binding; chromatin binding; transcription factor activity
Biological Process: G1 DNA damage checkpoint; ectoderm and mesoderm interaction; apoptosis; positive regulation of transcription, DNA-dependent; cloacal septation; epidermal cell division; negative regulation of transcription from RNA polymerase II promoter; protein homotetramerization; smooth muscle development; polarized epithelial cell differentiation; sympathetic nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of mesenchymal cell proliferation; regulation of neuron apoptosis; epithelial cell development; response to gamma radiation; establishment of planar polarity; skeletal development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; female genitalia morphogenesis; positive regulation of Notch signaling pathway; proximal/distal pattern formation; embryonic limb morphogenesis; response to X-ray; Notch signaling pathway; regulation of epidermal cell division; hair follicle morphogenesis; urinary bladder development; transcription, DNA-dependent; negative regulation of keratinocyte differentiation; multicellular organismal aging; cell aging; keratinocyte proliferation; odontogenesis of dentine-containing teeth; chromatin remodeling; keratinocyte differentiation; positive regulation of osteoblast differentiation; neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; negative regulation of apoptosis
Reference #:  Q9H3D4 (UniProtKB)
Alt. Names/Synonyms: AIS; amplified in squamous cell carcinoma; B(p51A); B(p51B); Chronic ulcerative stomatitis protein; CUSP; EEC3; Keratinocyte transcription factor KET; KET; LMS; NBP; OFC8; p40; p51; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L; Transformation-related protein 63; Tumor protein 63; tumor protein p53-competing protein; tumor protein p53-like; tumor protein p63; tumor protein p63 deltaN isoform delta; Tumor protein p73-like
Gene Symbols: TP63
Molecular weight: 76,785 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p63

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: Y149‑p
transcription, inhibited: S43‑p, S51‑p
molecular association, regulation: S43‑p, S51‑p
protein degradation: S477‑p, S479‑p, T491‑p, S560‑p
protein stabilization: Y149‑p, Y171‑p, Y290‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y13-p SRCATLQyCPDPyIQ
0 1 Y18-p LQyCPDPyIQRFVET
0 1 Y36-p FSWKESYyRSTMSQs
1 0 S41 SYyRSTMSQsTQTNE
1 1 S43-p yRSTMSQsTQTNEFL
1 1 S51-p TQTNEFLsPEVFQHI
1 0 Y149-p SVTAPSPyAQPSSTF
1 0 S160 SSTFDALSPSPAIPS
1 0 S162 TFDALSPSPAIPSNT
1 0 Y171-p AIPSNTDyPGPHSFD
0 1 Y231-p VIRAMPVyKKAEHVT
0 1 K242-m1 EHVTEVVkRCPNHEL
1 0 Y290-p RQSVLVPyEPPQVGT
0 1 T326-p RPILIIVtLEtRDGQ
0 1 T329-p LIIVtLEtRDGQVLG
0 2 S358-p DRKADEDsIRKQQVS
1 0 S395-p TSIKKRRsPDDELLY
0 1 T451-p QHLLQKQtSIQsPSS
1 0 S455-p QKQtSIQsPSSYGNs
0 1 S462-p sPSSYGNsSPPLNKM
1 0 S477-p NSMNKLPsVsQLINP
2 1 S479-p MNKLPsVsQLINPQQ
3 1 T491-p PQQRNALtPTTIPDG
1 0 T522 DMNGLSPTQALPPPL
1 1 S560-p LARLGCSsCLDYFTT
1 0 T567 sCLDYFTTQGLTTIY
1 0 K588-sm MDDLASLkIPEQFRH
0 2 K599-ub QFRHAIWkGILDHRQ
0 1 S630 ASTVSVGSSETRGER
0 1 S631 STVSVGSSETRGERV
0 1 R643 ERVIDAVRFTLRQTI
2 0 K676-sm RNKQQRIkEEGE___
4665 : Phospho-p73 (Tyr99) Antibody
4981 : Phospho-p63 (Ser160/162) Antibody
4981 : Phospho-p63 (Ser160/162) Antibody
  p63 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
Y55 SVTAPSPYAQPSSTF
S66-p SSTFDALsPsPAIPS
S68-p TFDALsPsPAIPSNT
Y77 AIPSNTDYPGPHSFD
Y137 VIRAMPVYKKAEHVT
K148 EHVTEVVKRCPNHEL
Y196 RQSVLVPYEPPQVGT
T232 RPILIIVTLETRDGQ
T235 LIIVTLETRDGQVLG
S264 DRKADEDSIRKQQVS
S301 TSIKKRRSPDDELLY
T357 QHLLQKQTSIQSPSS
S361 QKQTSIQSPSSYGNS
S368 SPSSYGNSSPPLNKM
S383 NSMNKLPSVSQLINP
S385 MNKLPSVSQLINPQQ
T397 PQQRNALTPTTIPDG
T428 DMNGLSPTQALPPPL
S466 LARLGCSSCLDYFTT
T473 SCLDYFTTQGLTTIY
K494 MDDLASLKIPEQFRH
K505 QFRHAIWKGILDHRQ
S536 ASTVSVGSSETRGER
S537 STVSVGSSETRGERV
R549 ERVIDAVRFTLRQTI
K582 RNKQQRIKEEGE___
  mouse

 
Y13 SRCATLQYCPDPYIQ
Y18 LQYCPDPYIQRFIET
Y36 FSWKESYYRSAMsQS
S41-p SYYRSAMsQSTQTSE
S43 YRSAMsQSTQTSEFL
S51 TQTSEFLSPEVFQHI
Y149 SVTAPSPYAQPSSTF
S160 SSTFDALSPSPAIPS
S162 TFDALSPSPAIPSNT
Y171 AIPSNTDYPGPHSFD
Y231 VIRAMPVYKKAEHVT
K242 EHVTEVVKRCPNHEL
Y290 RQSVLVPYEPPQVGT
T326 RPILIIVTLETRDGQ
T329 LIIVTLETRDGQVLG
S358 DRKADEDSIRKQQVS
S395 TSIKKRRSPDDELLY
T451 QHLLQKQTSMQSQSS
S455 QKQTSMQSQSSYGNS
S462 SQSSYGNSSPPLNKM
S477 NSMNKLPSVSQLINP
S479 MNKLPSVSQLINPQQ
T491 PQQRNALTPTTMPEG
T522-p DMNGLSPtQALPPPL
S560 LARLGCSSCLDYFTt
T567-p SCLDYFTtQGLTTIY
K588 MDDLASLKIPEQFRH
K599 QFRHAIWKGILDHRQ
S630-p ASTVSVGssETRGER
S631-p STVSVGssETRGERV
R643-m2 ERVIDAVrFTLRQTI
K676 RNKQQRIKEEGE___
4665 : Phospho-p73 (Tyr99) Antibody
4981 : Phospho-p63 (Ser160/162) Antibody
4981 : Phospho-p63 (Ser160/162) Antibody
  rat

 
Y13 SRCATLQYCPDPYIQ
Y18 LQYCPDPYIQRFIET
Y36 FSWKESYYRSAMSQS
S41 SYYRSAMSQSTQTSE
S43 YRSAMSQSTQTSEFL
S51 TQTSEFLSPEVFQHI
Y149 SVTAPSPYAQPSSTF
S160 SSTFDALSPSPAIPS
S162 TFDALSPSPAIPSNT
Y171 AIPSNTDYPGPHSFD
Y231 VIRAMPVYKKAEHVT
K242 EHVTEVVKRCPNHEL
Y290 RQSVLVPYEPPQVGT
T326 RPILIIVTLETRDGQ
T329 LIIVTLETRDGQVLG
S358 DRKADEDSIRKQQVS
S395 TSIKKRRSPDDELLY
T451 QHLLQKQTSMQSQSS
S455 QKQTSMQSQSSYGNS
S462 SQSSYGNSSPPLNKM
S477 NSMNKLPSVSQLINP
S479 MNKLPSVSQLINPQQ
T491 PQQRNALTPTTMPEG
T522 DMNGLSPTQALPPPL
S560 LARLGCSSCLDYFTT
T567 SCLDYFTTQGLTTIY
K588 MDDLASLKIPEQFRH
K599 QFRHAIWKGILDHRQ
S630 ASTVSVGSSETRGER
S631 STVSVGSSETRGERV
R643 ERVIDAVRFTLRQTI
K676 RNKQQRIKEEGE___
4665 : Phospho-p73 (Tyr99) Antibody
4981 : Phospho-p63 (Ser160/162) Antibody
4981 : Phospho-p63 (Ser160/162) Antibody
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