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Protein Page:
TPH1 (human)

Overview
TPH1 an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.14.16.4; Amino Acid Metabolism - tryptophan
Cellular Component: neuron projection; cytosol
Molecular Function: amino acid binding; tryptophan 5-monooxygenase activity; iron ion binding
Biological Process: circadian rhythm; indolalkylamine biosynthetic process; aromatic amino acid family metabolic process; negative regulation of ossification; bone remodeling; serotonin biosynthetic process
Reference #:  P17752 (UniProtKB)
Alt. Names/Synonyms: indoleacetic acid-5-hydroxylase; L-tryptophan hydroxylase; MGC119994; TPH; TPH1; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; tryptophan hydroxylase (tryptophan 5-monooxygenase); tryptophan hydroxylase 1
Gene Symbols: TPH1
Molecular weight: 50,985 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TPH1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
3 0 S58 RKSKRRNSEFEIFVD
0 1 T225-p SNFLKERtGFsIRPV
0 1 S228-p LKERtGFsIRPVAGY
0 1 S243 LSPRDFLSGLAFRVF
0 1 Y373-p ITTFQDVyFVSESFE
0 1 Y401-p KRPFGVKyNPyTRSI
0 1 Y404-p FGVKyNPyTRSIQIL
0 1 S407 KyNPyTRSIQILKDT
  mouse

 
S61 RKSKQRNSEFEIFVD
T228 SNFLKERTGFSIRPV
S231 LKERTGFSIRPVAGY
S246-p LSPRDFLsGLAFRVF
Y376 ITSFQDVYFVSESFE
Y404 KRPFGLKYNPYTQsV
Y407 FGLKYNPYTQsVQVL
S410-p KYNPYTQsVQVLRDT
  rat

 
S58-p RKSKRRNsEFEIFVD
T225 SNFLKERTGFSIRPV
S228 LKERTGFSIRPVAGY
S243 LSPRDFLSGLAFRVF
Y373 ITSFQDVYFVSESFE
Y401 KRPFGVKYNPYTQSI
Y404 FGVKYNPYTQSIQVL
S407 KYNPYTQSIQVLRDS
  rabbit

 
S58-p RKSKRRNsEFEIFVD
T225 SNFLKERTGFSIRPV
S228 LKERTGFSIRPVAGY
S243 LSPRDFLSGLAFRVF
Y373 ITTFQDVYFVSESFE
Y401 KRPFGVKYNPYTRSI
Y404 FGVKYNPYTRSIQIL
S407 KYNPYTRSIQILKDA
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