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TPH1 (human)

Overview TPH1 an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: EC 1.14.16.4; Amino Acid Metabolism - tryptophan; Oxidoreductase Cellular Component: neuron projection; cytosol Molecular Function: amino acid binding; tryptophan 5-monooxygenase activity; iron ion binding Biological Process: aromatic amino acid family metabolic process; indolalkylamine biosynthetic process; response to stress; bone remodeling; serotonin biosynthetic process Reference #:  P17752 (UniProtKB) Alt. Names/Synonyms: indoleacetic acid-5-hydroxylase; L-tryptophan hydroxylase; MGC119994; TPH; TPH1; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; tryptophan hydroxylase (tryptophan 5-monooxygenase); tryptophan hydroxylase 1 Gene Symbols: TPH1 Molecular weight: 50,985 Da Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TPH1 1IN9 - A=2-444 (human) 1MLW - A=102-402 (human) 3HF6 - A=104-393 (human) 3HF8 - A=104-393 (human) 3HFB - A=104-393 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1IN9 1MLW 3HF6 3HF8 3HFB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
3	0		S58	RKSKRRNSEFEIFVD
0	1		T225-p	SNFLKERtGFsIRPV
0	1		S228-p	LKERtGFsIRPVAGY
0	1		S243	LSPRDFLSGLAFRVF
0	1		Y373-p	ITTFQDVyFVSESFE
0	1		Y401-p	KRPFGVKyNPyTRSI
0	1		Y404-p	FGVKyNPyTRSIQIL
0	1		S407	KyNPyTRSIQILKDT

	mouse
S61	RKSKQRNSEFEIFVD
T228	SNFLKERTGFSIRPV
S231	LKERTGFSIRPVAGY
S246-p	LSPRDFLsGLAFRVF
Y376	ITSFQDVYFVSESFE
Y404	KRPFGLKYNPYTQsV
Y407	FGLKYNPYTQsVQVL
S410-p	KYNPYTQsVQVLRDT

	rat
S58-p	RKSKRRNsEFEIFVD
T225	SNFLKERTGFSIRPV
S228	LKERTGFSIRPVAGY
S243	LSPRDFLSGLAFRVF
Y373	ITSFQDVYFVSESFE
Y401	KRPFGVKYNPYTQSI
Y404	FGVKYNPYTQSIQVL
S407	KYNPYTQSIQVLRDS

	rabbit
S58-p	RKSKRRNsEFEIFVD
T225	SNFLKERTGFSIRPV
S228	LKERTGFSIRPVAGY
S243	LSPRDFLSGLAFRVF
Y373	ITTFQDVYFVSESFE
Y401	KRPFGVKYNPYTRSI
Y404	FGVKYNPYTRSIQIL
S407	KYNPYTRSIQILKDA

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