Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
GHF-1 (human)

Overview
GHF-1 Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3'. Belongs to the POU transcription factor family. Class- 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: sequence-specific DNA binding; chromatin binding; transcription factor activity; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; nuclear transport; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; cell fate specification; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; determination of adult life span; negative regulation of cell proliferation; B cell differentiation; somatotropin secreting cell development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P28069 (UniProtKB)
Alt. Names/Synonyms: CPHD1; GHF-1; GHF1; Growth hormone factor 1; PIT-1; PIT1; Pituitary-specific positive transcription factor 1; pituitary-specific transcription factor 1; POU class 1 homeobox 1; POU domain, class 1, transcription factor 1; POU1F1
Gene Symbols: POU1F1
Molecular weight: 32,912 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
Select Structure to View Below

GHF-1

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S115 KQELRRKSKLVEEPI
0 1 T219-p ERKRKRRtTISIAAK
3 0 T220 RKRKRRtTISIAAKD
0 1 T274-p QREKRVKtsLNQSLF
0 1 S275-p REKRVKtsLNQSLFS
  mouse

 
S115 KQELRRKSKLVEEPI
T219 ERKRKRRTTISVAAK
T220 RKRKRRTTISVAAKD
T274 QREKRVKTSLNQSLF
S275 REKRVKTSLNQSLFS
  rat

 
S115-p KQELRRKsKLVEEPI
T219 ERKRKRRTtISIAAK
T220-p RKRKRRTtISIAAKD
T274 QREKRVKTSLNQSLF
S275 REKRVKTSLNQSLFS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.