Home

GHF-1 (human)

Overview GHF-1 Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3'. Belongs to the POU transcription factor family. Class- 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function: sequence-specific DNA binding; chromatin binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; B cell differentiation; positive regulation of cell proliferation; somatotropin secreting cell development; positive regulation of transcription from RNA polymerase II promoter; cell fate specification; positive regulation of inositol trisphosphate biosynthetic process; determination of adult life span; positive regulation of multicellular organism growth Reference #:  P28069 (UniProtKB) Alt. Names/Synonyms: CPHD1; GHF-1; GHF1; Growth hormone factor 1; PIT-1; PIT1; Pituitary-specific positive transcription factor 1; pituitary-specific transcription factor 1; POU class 1 homeobox 1; POU domain, class 1, transcription factor 1; POU1F1 Gene Symbols: POU1F1 Molecular weight: 32,912 Da Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states

Select Structure to View Below GHF-1 1AU7 - A/B=130-273 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 173110 262600  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		S115	KQELRRKSKLVEEPI
0	1		T219-p	ERKRKRRtTISIAAK
3	0		T220	RKRKRRtTISIAAKD

	mouse
S115	KQELRRKSKLVEEPI
T219	ERKRKRRTTISVAAK
T220	RKRKRRTTISVAAKD

	rat
S115-p	KQELRRKsKLVEEPI
T219	ERKRKRRTtISIAAK
T220-p	RKRKRRTtISIAAKD

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.