Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
prolactin (human)

Overview
prolactin Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Cytokine; Motility/polarity/chemotaxis; Secreted, signal peptide
Cellular Component: extracellular region
Molecular Function: protein binding; prolactin receptor binding; hormone activity
Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; female pregnancy
Reference #:  P01236 (UniProtKB)
Alt. Names/Synonyms: PRL; Prolactin
Gene Symbols: PRL
Molecular weight: 25,876 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
Select Structure to View Below

prolactin

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell cycle regulation: S179‑p
protein conformation: S207‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S54 FDRAVVLSHYIHNLS
1 0 S62 HYIHNLSSEMFSEFD
1 1 T88 KAINSCHTSSLATPE
1 1 T93 CHTSSLATPEDKEQA
2 0 S118 LIVSILRSWNEPLYH
1 1 S163-p EGMELIVsQVHPETK
9 0 S179-p NEIYPVWsGLPSLQM
1 1 S194-p ADEESRLsAYYNLLH
3 1 S207-p LHCLRRDsHKIDNYL
  mouse

 
S53 FDRVVILSHYIHTLY
T61 HYIHTLYTDMFIEFD
T87 KVINDCPTSSLATPE
T92 CPTSSLATPEDKEQA
S117 LILSLVQSSSDPLFQ
S162 EGVEKIISQAYPEAK
S178 NGIYFVWSQLPSLQG
L193 VDEESKILSLRNTIR
S206 IRCLRRDSHKVDNFL
  rat

 
S53 FDRVVMLSHYIHTLY
T61 HYIHTLYTDMFIEFD
T87-p KAINDCPtSSLAtPE
T92-p CPtSSLAtPEDKEQA
S117 LILSLVHSWNDPLFQ
S162 EGIEKIISQAYPEAK
S178 NEIYLVWSQLPSLQG
L193 VDEESKDLAFYNNIR
S206-p IRCLRRDsHKVDNYL
  sheep

 
S56 FDRAVMVSHYIHNLS
S64 HYIHNLSSEMFNEFD
T90 MALNSCHTSSLPTPE
T95 CHTSSLPTPEDKEQA
S120 LILGLLRSWNDPLYH
G165 EGMEMIFGQVIPGAK
S181-p TEPYPVWsGLPSLQT
S196 KDEDARHSAFYNLLH
S209 LHCLRRDSSKIDTYL
  cow

 
S56-p FDRAVMVsHYIHDLS
S64-p HYIHDLSsEMFNEFD
T90 MALNSCHTSSLPTPE
T95 CHTSSLPTPEDKEQA
S120-p LILGLLRsWNDPLYH
G165 EGMEMIFGQVIPGAK
S181 TEPYPVWSGLPSLQT
S196 KDEDARYSAFYNLLH
S209 LHCLRRDSSKIDTYL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.