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Protein Page:
prolactin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
prolactin Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Cytokine
Cellular Component: extracellular region
Molecular Function: protein binding; prolactin receptor binding; hormone activity
Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; female pregnancy
Reference #:  P01236 (UniProtKB)
Alt. Names/Synonyms: PRL; Prolactin
Gene Symbols: PRL
Molecular weight: 25,876 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
Select Structure to View Below

prolactin

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S179‑p
protein conformation: S207‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S54 FDRAVVLSHYIHNLS
1 0 S62 HYIHNLSSEMFSEFD
1 1 T88 KAINSCHTSSLATPE
1 1 T93 CHTSSLATPEDKEQA
2 0 S118 LIVSILRSWNEPLYH
1 1 S163-p EGMELIVsQVHPETK
9 0 S179-p NEIYPVWsGLPSLQM
1 1 S194-p ADEESRLsAYYNLLH
3 1 S207-p LHCLRRDsHKIDNYL
0 1 K209 CLRRDsHKIDNYLKL
  mouse

 
S53 FDRVVILSHYIHTLY
T61 HYIHTLYTDMFIEFD
T87 KVINDCPTSSLATPE
T92 CPTSSLATPEDKEQA
S117 LILSLVQSSSDPLFQ
S162 EGVEKIISQAYPEAK
S178 NGIYFVWSQLPSLQG
L193 VDEESKILSLRNTIR
S206 IRCLRRDSHkVDNFL
K208-ub CLRRDSHkVDNFLKV
  rat

 
S53 FDRVVMLSHYIHTLY
T61 HYIHTLYTDMFIEFD
T87-p KAINDCPtSSLAtPE
T92-p CPtSSLAtPEDKEQA
S117 LILSLVHSWNDPLFQ
S162 EGIEKIISQAYPEAK
S178 NEIYLVWSQLPSLQG
L193 VDEESKDLAFYNNIR
S206-p IRCLRRDsHKVDNYL
K208 CLRRDsHKVDNYLKF
  sheep

 
S56 FDRAVMVSHYIHNLS
S64 HYIHNLSSEMFNEFD
T90 MALNSCHTSSLPTPE
T95 CHTSSLPTPEDKEQA
S120 LILGLLRSWNDPLYH
G165 EGMEMIFGQVIPGAK
S181-p TEPYPVWsGLPSLQT
S196 KDEDARHSAFYNLLH
S209 LHCLRRDSSKIDTYL
K211 CLRRDSSKIDTYLKL
  cow

 
S56-p FDRAVMVsHYIHDLS
S64-p HYIHDLSsEMFNEFD
T90 MALNSCHTSSLPTPE
T95 CHTSSLPTPEDKEQA
S120-p LILGLLRsWNDPLYH
G165 EGMEMIFGQVIPGAK
S181 TEPYPVWSGLPSLQT
S196 KDEDARYSAFYNLLH
S209 LHCLRRDSSKIDTYL
K211 CLRRDSSKIDTYLKL
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