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Protein Page:
ADCY6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ADCY6 a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Nucleotide Metabolism - purine; Lyase; Transporter, aquaporin family; EC 4.6.1.1; Adenylyl cyclase; Membrane protein, multi-pass; Transporter
Cellular Component: membrane; integral to membrane; plasma membrane; cilium
Molecular Function: protein binding; metal ion binding; protein kinase binding; ATP binding; adenylate cyclase activity
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; phospholipase C activation; dopamine receptor signaling pathway; energy reserve metabolic process; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport
Reference #:  O43306 (UniProtKB)
Alt. Names/Synonyms: AC6; ADCY6; adenylate cyclase 6; Adenylate cyclase type 6; Adenylate cyclase type VI; Adenylyl cyclase 6; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase; DKFZp779F075; KIAA0422
Gene Symbols: ADCY6
Molecular weight: 130,615 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Select Structure to View Below

ADCY6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 - gap
0 1 T40-p TRAGGFCtPRYMSCL
0 10 S54-p LRDAEPPsPTPAGPP
0 2 T98 FEDTEVTTTAGGTAE
0 2 K129-ub LVQVFQSkQFRSAKL
0 1 S207-p RHSFRQDsMWVVsYV
0 1 S212-p QDsMWVVsYVVLGIL
1 0 S556 TFLILGASQKRKEEK
0 1 K568 EEKAMLAKLQRtRAN
0 3 T572-p MLAKLQRtRANsMEG
0 143 S576-p LQRtRANsMEGLMPR
1 0 S591 WVPDRAFSRTKDSKA
1 0 S596 AFSRTKDSKAFRQMG
0 1 S607-p RQMGIDDssKDNRGT
0 1 S608-p QMGIDDssKDNRGTQ
0 1 K609 MGIDDssKDNRGTQD
0 1 S636 SRAIDARSIDQLRKD
2 0 S662 EDLEKKYSRKVDPRF
2 0 S732 PKALQRLSRSIVRSR
2 0 S734 ALQRLSRSIVRSRAH
2 0 S738 LSRSIVRSRAHSTAV
2 0 S742 IVRSRAHSTAVGIFS
1 0 T919 HAQQVESTARLDFLW
0 1 K934 KLQATGEKEEMEELQ
0 1 K1101 AGVIGARKPQYDIWG
  mouse

 
- gap
A39 NRASGFCAPRYMSCL
S53-p LKNAEPPsPTPAAHT
T97-p FDDTEVTtPMGTAEV
K127-ub LVQVFQSkQFRSAKL
S205 RHSFRQDSMWVVSYV
S210 QDSMWVVSYVVLGIL
S553 TFLILGASQKRKEEK
K565-ub EEKAMLAkLQRtRAN
T569-p MLAkLQRtRANsMEG
S573-p LQRtRANsMEGLMPR
S588 WVPDRAFSRTKDSKA
S593 AFSRTKDSKAFRQMG
S604 RQMGIDDSSkDNRGA
S605 QMGIDDSSkDNRGAQ
K606-ub MGIDDSSkDNRGAQD
S633-p GRAIDARsIDQLRKD
S659 EDLEKKYSRKVDPRF
S729 PKALQRLSRNIVRSR
N731 ALQRLSRNIVRSRVH
S735 LSRNIVRSRVHSTAV
S739 IVRSRVHSTAVGIFS
T916 HAQQVESTARLDFLW
K931-ub KLQATGEkEEMEELQ
K1098-ub AGVIGARkPQYDIWG
  rat

 
S10-p LPVARSGsGRSSMSW
A53 TRARGFCAPRYMSCL
S67-p LKNVEPPsPTPAART
T111 FDDTEVTTPMGTAEV
K141 LAQVFQSKQFPSAKL
S219 RHSFRQDSMWVVSYV
S224 QDSMWVVSYVVLGIL
S568-p TFLILGAsQKRKEEK
K580 EEKAMLVKLQRTRAN
T584 MLVKLQRTRANsMEG
S588-p LQRTRANsMEGLMPR
S603-p WVPDRAFsRTKDsKA
S608-p AFsRTKDsKAFRQMG
S619 RQMGIDDSSKENRGA
S620 QMGIDDSSKENRGAQ
K621 MGIDDSSKENRGAQD
S648 GRAIDARSIDQLRKD
S674-p EDLEKKYsRKVDPRF
S744-p PNALQRLsRsIVRsR
S746-p ALQRLsRsIVRsRVH
S750-p LsRsIVRsRVHsTAV
S754-p IVRsRVHsTAVGVFS
T931-p HAQQVEStARLDFLW
K946 KLQATGEKEEMEELQ
K1113 AGVIGARKPQYDIWG
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