is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: nucleoplasm; cell surface; cell soma; perinuclear region of cytoplasm; nuclear chromatin; cytoplasm; dendrite; nucleus
Molecular Function: protein domain specific binding; protein kinase B binding; retinoic acid binding; zinc ion binding; chromatin DNA binding; translation repressor activity, nucleic acid binding; transcription coactivator activity; phosphoinositide 3-kinase regulator activity; drug binding; transcription factor binding; protein binding; enzyme binding; protein heterodimerization activity; sequence-specific DNA binding; protein kinase A binding; steroid hormone receptor activity; mRNA 5'-UTR binding; retinoic acid receptor activity; transcription factor activity; transcription corepressor activity; receptor binding
Biological Process: retinoic acid receptor signaling pathway; prostate gland development; negative regulation of translational initiation; estrogen receptor signaling pathway; regulation of myelination; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell differentiation; regulation of synaptic plasticity; female pregnancy; negative regulation of transcription from RNA polymerase II promoter; signal transduction; protein amino acid phosphorylation; regulation of phosphoinositide 3-kinase activity; response to estradiol stimulus; negative regulation of granulocyte differentiation; germ cell development; response to vitamin A; positive regulation of interleukin-4 production; regulation of apoptosis; negative regulation of cell proliferation; Sertoli cell fate commitment; positive regulation of T-helper 2 cell differentiation; ureteric bud development; negative regulation of interferon-gamma production; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; transcription initiation from RNA polymerase II promoter; response to retinoic acid; multicellular organism growth; positive regulation of cell cycle; negative regulation of tumor necrosis factor production; positive regulation of binding; liver development; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; response to ethanol; response to cytokine stimulus; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; spermatogenesis; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; apoptotic cell clearance
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.