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RARA
is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor; DNA binding protein; Transcription factor |
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Cellular Component: nucleoplasm; cell surface; cell soma; cytoplasm; dendrite; nuclear chromatin; nucleus
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Molecular Function: protein domain specific binding; protein kinase B binding; retinoic acid binding; zinc ion binding; chromatin DNA binding; transcription coactivator activity; transcription factor binding; protein binding; enzyme binding; sequence-specific DNA binding; protein heterodimerization activity; protein kinase A binding; steroid hormone receptor activity; retinoic acid receptor activity; transcription corepressor activity; transcription factor activity; receptor binding
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Biological Process: retinoic acid receptor signaling pathway; negative regulation of translational initiation; estrogen receptor signaling pathway; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; protein amino acid phosphorylation; response to estradiol stimulus; germ cell development; negative regulation of granulocyte differentiation; positive regulation of interleukin-4 production; Sertoli cell fate commitment; positive regulation of T-helper 2 cell differentiation; ureteric bud development; negative regulation of interferon-gamma production; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; transcription initiation from RNA polymerase II promoter; response to retinoic acid; multicellular organism growth; positive regulation of cell cycle; negative regulation of tumor necrosis factor production; positive regulation of binding; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; gene expression; negative regulation of transcription, DNA-dependent; apoptotic cell clearance
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Reference #:
P10276 (UniProtKB)
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| Alt. Names/Synonyms: NR1B1; Nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR; RAR-alpha; RARA; Retinoic acid receptor alpha; retinoic acid receptor, alpha; Retinoic acid receptor, alpha polypeptide |
| Gene Symbols: RARA |
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Molecular weight: 50,771 Da
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Basal Isoelectric point: 8.21
Predict pI for various phosphorylation states
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CST Pathways:
Signaling Pathways Activating p38 MAPK
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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