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Tor1a
May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Secreted, signal peptide; Secreted |
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Cellular Component: nuclear membrane; endoplasmic reticulum lumen; endoplasmic reticulum; cytoplasm
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Molecular Function: serine-type endopeptidase activity; unfolded protein binding; ATP binding
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Biological Process: chaperone cofactor-dependent protein folding; protein folding; protein homooligomerization; response to unfolded protein
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Reference #:
O14656 (UniProtKB)
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| Alt. Names/Synonyms: DQ2; Dystonia 1 protein; dystonia 1, torsion (autosomal dominant; DYT1; TOR1A; torsin A); Torsin family 1 member A; torsin family 1, member A (torsin A); Torsin-1A |
| Gene Symbols: TOR1A |
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Molecular weight: 37,809 Da
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Basal Isoelectric point: 6.51
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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