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Protein Page:
Tor1a (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Tor1a May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: synaptic vesicle; transport vesicle; nuclear membrane; growth cone; cytoplasmic vesicle membrane; cytoskeleton; intracellular membrane-bound organelle; membrane; endoplasmic reticulum lumen; nuclear envelope; cell junction; secretory granule
Molecular Function: protein binding; kinesin binding; cytoskeletal protein binding; ATPase activity; unfolded protein binding; ATP binding
Biological Process: ATP catabolic process; protein deneddylation; chaperone cofactor-dependent protein folding; organelle organization and biogenesis; synaptic vesicle transport; regulation of dopamine uptake; intermediate filament cytoskeleton organization and biogenesis; response to oxidative stress; cell adhesion; nuclear membrane organization and biogenesis; neurite development; protein homooligomerization
Reference #:  O14656 (UniProtKB)
Alt. Names/Synonyms: DQ2; Dystonia 1 protein; dystonia 1, torsion (autosomal dominant; DYT1; TOR1A; torsin A); Torsin family 1 member A; torsin family 1, member A (torsin A); Torsin-1A
Gene Symbols: TOR1A
Molecular weight: 37,809 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Tor1a

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K63 LSREALQKDLDDNLF
0 1 N68 LQKDLDDNLFGQHLA
0 1 K76 LFGQHLAKKIILNAV
0 1 S250 SVFNNKNSGFWHSSL
0 1 S255 KNSGFWHSSLIDRNL
0 1 S256 NSGFWHSSLIDRNLI
0 1 K309-ub EEMTFFPkEERVFSD
0 1 K325-ub GCKTVFTkLDYYYDD
  mouse

 
K64-ac LSREALQkDLDNkLF
K69-ac LQkDLDNkLFGQHLA
K77-ac LFGQHLAkKVILNAV
S251-p SVFNNKNsGFWHssL
S256-p KNsGFWHssLIDRNL
S257-p NsGFWHssLIDRNLI
K310 EEMTFFPKEEKVFSD
K326 GCKTVFTKLDYYLDD
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