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Protein Page:
Tor1a (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Tor1a May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: nuclear membrane; neuron projection; cytoplasmic vesicle membrane; membrane; intracellular membrane-bound organelle; endoplasmic reticulum lumen; endoplasmic reticulum; cytoplasm
Molecular Function: protein binding; kinesin binding; serine-type endopeptidase activity; unfolded protein binding; ATPase activity; ATP binding
Biological Process: ATP catabolic process; chaperone cofactor-dependent protein folding; protein folding; response to oxidative stress; response to unfolded protein; protein homooligomerization
Reference #:  O14656 (UniProtKB)
Alt. Names/Synonyms: DQ2; Dystonia 1 protein; dystonia 1, torsion (autosomal dominant; DYT1; TOR1A; torsin A); Torsin family 1 member A; torsin family 1, member A (torsin A); Torsin-1A
Gene Symbols: TOR1A
Molecular weight: 37,809 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Tor1a

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K309-u EEMTFFPkEERVFSD
0 1 K325-u GCKTVFTkLDYYYDD
  mouse

 
K310 EEMTFFPKEEKVFSD
K326 GCKTVFTKLDYYLDD
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