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Protein Page:
FOXP3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXP3 Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell cycle regulation; DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: protein complex; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; NF-kappaB binding; protein binding; protein homodimerization activity; NFAT protein binding; sequence-specific DNA binding; metal ion binding; histone deacetylase binding; transcription corepressor activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; negative regulation of interleukin-4 production; negative regulation of interleukin-10 production; T cell activation; negative regulation of activated T cell proliferation; positive regulation of transcription, DNA-dependent; myeloid cell homeostasis; negative regulation of cytokine secretion; T cell receptor signaling pathway; negative regulation of histone acetylation; negative regulation of interleukin-2 production; negative regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-4 production; negative regulation of cell proliferation; negative regulation of isotype switching to IgE isotypes; negative regulation of T cell proliferation; B cell homeostasis; regulation of transcription, DNA-dependent; negative regulation of interferon-gamma production; negative regulation of interleukin-6 production; T cell homeostasis; regulation of isotype switching to IgG isotypes; positive regulation of T cell anergy; tolerance induction to self antigen; positive regulation of transforming growth factor-beta1 production; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; negative regulation of chronic inflammatory response; negative regulation of histone deacetylation; response to virus; negative regulation of transcription factor activity; T cell mediated immunity; negative regulation of immune response; cytokine production; positive regulation of immature T cell proliferation in the thymus; negative regulation of tumor necrosis factor production; negative regulation of T cell cytokine production; positive regulation of peripheral T cell tolerance induction; chromatin remodeling; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; inhibition of NF-kappaB transcription factor; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-5 production; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; inhibition of CREB transcription factor; negative regulation of cytokine biosynthetic process
Reference #:  Q9BZS1 (UniProtKB)
Alt. Names/Synonyms: AIID; DIETER; forkhead box P3; Forkhead box protein P3; FOXP3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; Scurfin; XPID
Gene Symbols: FOXP3
Molecular weight: 47,244 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXP3

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, inhibited: Y342‑p
cell growth, inhibited: S418‑p
transcription, induced: S418‑p
transcription, inhibited: Y342‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S19 PSLALGPSPGASPsW
0 1 S25-p PSPGASPsWRAAPkA
0 1 R27 PGASPsWRAAPkAsD
2 0 K31-ac PsWRAAPkAsDLLGA
0 1 S33-p WRAAPkAsDLLGARG
0 1 T44-p GARGPGGtFQGRDLR
0 1 T115-p TVDAHARtPVLQVHP
0 1 T138-p LTPPTTAtGVFsLKA
0 1 S142-p TTAtGVFsLKARPGL
1 0 A176 CTFPNPSAPRkDSTL
1 0 K179-ac PNPSAPRkDSTLSAV
1 0 K227-ac ADHLLDEkGRAQCLL
1 0 K250-ac EQQLVLEkEkLSAMQ
1 0 K252-ac QLVLEkEkLSAMQAH
1 0 K263-ac MQAHLAGkMALTkAS
2 0 K268-ac AGkMALTkASSVAss
0 1 S274-p TkASSVAssDKGSCC
0 1 S275-p kASSVAssDKGSCCI
1 0 Y342-p NMRPPFTyATLIRWA
2 0 S418-p LEFRKKRsQRPsRCS
1 0 S422-p KKRsQRPsRCSNPTP
  mouse

 
S19-p PSLALGPsPGVLPSW
S25 PsPGVLPSWkTAPkG
K27-ub PGVLPSWkTAPkGSE
K31-ac PSWkTAPkGSELLGT
S33 WkTAPkGSELLGTRG
P44 GTRGSGGPFQGRDLR
T114 TVDAHAQTPVLQVRP
T137 LPPPSAATGVFSLKA
S141 SAATGVFSLKARPGL
T175-p CTFPRSGtPRKDSNL
K178 PRSGtPRKDSNLLAA
K226 ADHLLDEKGKAQCLL
K249 EQQLELEKEKLGAMQ
K251 QLELEKEKLGAMQAH
K262-ac MQAHLAGkMALAkAP
K267-ac AGkMALAkAPSVASM
S273 AkAPSVASMDKSSCC
M274 kAPSVASMDKSSCCI
Y342 NMRPPFTYATLIRWA
S418 FEFRKKRSQRPNKCS
N422 KKRSQRPNKCSNPCP
  rat

 
S19 PSLAPGPSPGGLPSW
S25 PSPGGLPSWKTAPKG
K27 PGGLPSWKTAPKGSE
K31 PSWKTAPKGSELLGT
S33 WKTAPKGSELLGTRG
P44 GTRGPGGPFQGRDLR
T115 TVDAHGHTPVLQVRP
T138 LPPPTAATGVFSLKA
S142 TAATGVFSLKARPGL
T176 CTFPRSGTPRKDSNL
K179 PRSGTPRKDSNLLAA
K226 under review
K250 EQQLELEKEKLGAMQ
K252 QLELEKEKLGAMQAH
K263 MQAHLAGKMALTKAP
K268 AGKMALTKAPPVASV
S274 TKAPPVASVDKSSCC
V275 KAPPVASVDKSSCCL
Y342 NMRPPFTYATLIRWA
S418 FEFRKKRSQRPSKCS
S422 KKRSQRPSKCSNPCP
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