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FOXP3
Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Cell cycle regulation; C2H2-type zinc finger protein; Transcription factor |
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Cellular Component: transcription factor complex; protein complex; cytoplasm; nucleus
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Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein homodimerization activity; NFAT protein binding; zinc ion binding; histone deacetylase binding; histone acetyltransferase binding; NF-kappaB binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; double-stranded DNA binding; chromatin binding; DNA bending activity; transcription factor activity; transcription corepressor activity
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Biological Process: caudate nucleus development; negative regulation of interleukin-10 production; positive regulation of transcription, DNA-dependent; negative regulation of cytokine secretion; myeloid cell homeostasis; T cell receptor signaling pathway; negative regulation of interleukin-2 production; post-embryonic development; positive regulation of mesenchymal cell proliferation; negative regulation of interleukin-6 production; cerebellum development; T cell homeostasis; tolerance induction to self antigen; skeletal muscle development; camera-type eye development; negative regulation of transcription factor activity; response to virus; putamen development; negative regulation of immune response; cytokine production; negative regulation of T cell cytokine production; positive regulation of peripheral T cell tolerance induction; inhibition of NF-kappaB transcription factor; negative regulation of interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; inhibition of CREB transcription factor; negative regulation of transcription, DNA-dependent; alveolus development; negative regulation of cytokine biosynthetic process; negative regulation of interleukin-4 production; T cell activation; negative regulation of activated T cell proliferation; vocal learning; negative regulation of interferon-gamma biosynthetic process; negative regulation of histone acetylation; positive regulation of interleukin-4 production; negative regulation of cell proliferation; smooth muscle development; negative regulation of isotype switching to IgE isotypes; negative regulation of T cell proliferation; B cell homeostasis; regulation of transcription, DNA-dependent; negative regulation of interferon-gamma production; regulation of isotype switching to IgG isotypes; positive regulation of T cell anergy; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of transforming growth factor-beta1 production; negative regulation of chronic inflammatory response; negative regulation of histone deacetylation; righting reflex; T cell mediated immunity; positive regulation of immature T cell proliferation in the thymus; negative regulation of tumor necrosis factor production; pattern specification process; chromatin remodeling; embryonic development; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; negative regulation of interleukin-2 biosynthetic process; positive regulation of histone acetylation; growth
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Reference #:
Q9BZS1 (UniProtKB)
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| Alt. Names/Synonyms: AIID; DIETER; forkhead box P3; Forkhead box protein P3; FOXP3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; Scurfin; XPID |
| Gene Symbols: FOXP3 |
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Molecular weight: 47,244 Da
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Basal Isoelectric point: 9.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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