Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein; C2H2-type zinc finger protein; Cell cycle regulation
Cellular Component: protein complex; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein homodimerization activity; NFAT protein binding; histone deacetylase binding; metal ion binding; histone acetyltransferase binding; NF-kappaB binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; chromatin binding; transcription factor activity; transcription corepressor activity; DNA bending activity
Biological Process: negative regulation of interleukin-10 production; positive regulation of transcription, DNA-dependent; negative regulation of cytokine secretion; myeloid cell homeostasis; T cell receptor signaling pathway; cardiac muscle cell differentiation; negative regulation of interleukin-2 production; positive regulation of mesenchymal cell proliferation; negative regulation of interleukin-6 production; T cell homeostasis; tolerance induction to self antigen; skeletal muscle development; negative regulation of transcription factor activity; response to virus; negative regulation of immune response; cytokine production; negative regulation of T cell cytokine production; positive regulation of peripheral T cell tolerance induction; inhibition of NF-kappaB transcription factor; negative regulation of interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; inhibition of CREB transcription factor; negative regulation of transcription, DNA-dependent; negative regulation of cytokine biosynthetic process; positive regulation of epithelial cell proliferation; negative regulation of interleukin-4 production; T cell activation; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma biosynthetic process; negative regulation of histone acetylation; positive regulation of interleukin-4 production; negative regulation of cell proliferation; smooth muscle development; negative regulation of isotype switching to IgE isotypes; negative regulation of T cell proliferation; B cell homeostasis; regulation of transcription, DNA-dependent; negative regulation of interferon-gamma production; regulation of isotype switching to IgG isotypes; positive regulation of T cell anergy; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of transforming growth factor-beta1 production; negative regulation of chronic inflammatory response; negative regulation of histone deacetylation; immunoglobulin V(D)J recombination; T cell mediated immunity; positive regulation of immature T cell proliferation in the thymus; negative regulation of tumor necrosis factor production; pattern specification process; chromatin remodeling; positive regulation of immunoglobulin production; pre-B cell differentiation; embryonic development; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; negative regulation of interleukin-2 biosynthetic process; positive regulation of histone acetylation; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.