Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
FOXP3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FOXP3 Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein; C2H2-type zinc finger protein; Cell cycle regulation
Cellular Component: protein complex; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein homodimerization activity; NFAT protein binding; histone deacetylase binding; metal ion binding; histone acetyltransferase binding; NF-kappaB binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; chromatin binding; transcription factor activity; transcription corepressor activity; DNA bending activity
Biological Process: negative regulation of interleukin-10 production; positive regulation of transcription, DNA-dependent; negative regulation of cytokine secretion; myeloid cell homeostasis; T cell receptor signaling pathway; cardiac muscle cell differentiation; negative regulation of interleukin-2 production; positive regulation of mesenchymal cell proliferation; negative regulation of interleukin-6 production; T cell homeostasis; tolerance induction to self antigen; skeletal muscle development; negative regulation of transcription factor activity; response to virus; negative regulation of immune response; cytokine production; negative regulation of T cell cytokine production; positive regulation of peripheral T cell tolerance induction; inhibition of NF-kappaB transcription factor; negative regulation of interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; inhibition of CREB transcription factor; negative regulation of transcription, DNA-dependent; negative regulation of cytokine biosynthetic process; positive regulation of epithelial cell proliferation; negative regulation of interleukin-4 production; T cell activation; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma biosynthetic process; negative regulation of histone acetylation; positive regulation of interleukin-4 production; negative regulation of cell proliferation; smooth muscle development; negative regulation of isotype switching to IgE isotypes; negative regulation of T cell proliferation; B cell homeostasis; regulation of transcription, DNA-dependent; negative regulation of interferon-gamma production; regulation of isotype switching to IgG isotypes; positive regulation of T cell anergy; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of transforming growth factor-beta1 production; negative regulation of chronic inflammatory response; negative regulation of histone deacetylation; immunoglobulin V(D)J recombination; T cell mediated immunity; positive regulation of immature T cell proliferation in the thymus; negative regulation of tumor necrosis factor production; pattern specification process; chromatin remodeling; positive regulation of immunoglobulin production; pre-B cell differentiation; embryonic development; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; negative regulation of interleukin-2 biosynthetic process; positive regulation of histone acetylation; lung development
Reference #:  Q9BZS1 (UniProtKB)
Alt. Names/Synonyms: AIID; DIETER; forkhead box P3; Forkhead box protein P3; FOXP3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; Scurfin; XPID
Gene Symbols: FOXP3
Molecular weight: 47,244 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXP3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
carcinogenesis, inhibited: Y342‑p
cell growth, inhibited: S418‑p
transcription, induced: S418‑p
transcription, inhibited: Y342‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S19-p PSLALGPsPGASPsW
0 2 S25-p PsPGASPsWRAAPkA
2 0 K31-a PsWRAAPkASDLLGA
1 0 A176 CTFPNPSAPRkDSTL
1 0 K179-a PNPSAPRkDSTLSAV
1 0 K227-a ADHLLDEkGRAQCLL
1 0 K250-a EQQLVLEkEkLSAMQ
1 0 K252-a QLVLEkEkLSAMQAH
1 0 K263-a MQAHLAGkMALTkAS
2 0 K268-a AGkMALTkASSVASS
1 0 Y342-p NMRPPFTyATLIRWA
1 0 S418-p LEFRKKRsQRPSRCS
  mouse

 
S19-p PSLALGPsPGVLPSW
S25 PsPGVLPSWKTAPkG
K31-a PSWKTAPkGSELLGT
T175-p CTFPRSGtPRKDSNL
K178 PRSGtPRKDSNLLAA
K226 ADHLLDEKGKAQCLL
K249 EQQLELEKEKLGAMQ
K251 QLELEKEKLGAMQAH
K262-a MQAHLAGkMALAkAP
K267-a AGkMALAkAPSVASM
Y342 NMRPPFTYATLIRWA
S418 FEFRKKRSQRPNKCS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.