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Protein Page:
COX-1 (human)

Overview
COX-1 May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.99.1
Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus
Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding
Biological Process: xenobiotic metabolic process; regulation of blood pressure; cyclooxygenase pathway; arachidonic acid metabolic process; response to oxidative stress; lipid metabolic process; prostaglandin biosynthetic process; regulation of cell proliferation
Reference #:  P23219 (UniProtKB)
Alt. Names/Synonyms: COX-1; COX1; cyclooxygenase-1; Cyclooxygenase-1; PCOX1; PGG/HS; PGH synthase 1; PGH1; PGHS-1; PGHS1; PHS 1; PHS1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS; PTGS1; RP11-542K23.6
Gene Symbols: PTGS1
Molecular weight: 68,686 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

COX-1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y54-p VRFGLDRyQCDCTRT
0 2 T117-p MLMRLVLtVRSNLIP
0 1 T220-p GKMGPGFtKALGHGV
  mouse

 
Y57 VRFGLDNYQCDCTRT
T120 VLMRLVLTVRSNLIP
T223 GKMGPGFTKALGHGV
  sheep

 
Y55 VRFGLDRYQCDCTRT
T118 TLMRLVLTVRSNLIP
T221 GKMGPGFTKALGHGV
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