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COX-1 (human)

Overview COX-1 May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Oxidoreductase; EC 1.14.99.1; Lipid Metabolism - arachidonic acid Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nuclear envelope; cytoplasmic part; nucleus Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; prostaglandin-endoperoxide synthase activity; peroxidase activity; metal ion binding; heme binding; lipid binding Biological Process: cyclooxygenase pathway; response to organic nitrogen; prostaglandin biosynthetic process; regulation of cell proliferation; xenobiotic metabolic process; regulation of blood pressure; negative regulation of epinephrine secretion; positive regulation of vasoconstriction; positive regulation of smooth muscle contraction; response to oxidative stress; lipid metabolic process; fatty acid biosynthetic process; aging; response to corticosterone stimulus Reference #:  P23219 (UniProtKB) Alt. Names/Synonyms: COX-1; COX1; cyclooxygenase-1; Cyclooxygenase-1; PCOX1; PGG/HS; PGH synthase 1; PGH1; PGHS-1; PGHS1; PHS 1; PHS1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS; PTGS1; RP11-542K23.6 Gene Symbols: PTGS1 Molecular weight: 68,686 Da Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below COX-1

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  ENZYME  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y54-p	VRFGLDRyQCDCTRT
0	2		T117-p	MLMRLVLtVRSNLIP
0	1		T220-p	GKMGPGFtKALGHGV

	mouse
Y57	VRFGLDNYQCDCTRT
T120	VLMRLVLTVRSNLIP
T223	GKMGPGFTKALGHGV

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