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Protein Page:
PUMA (human)

Overview
PUMA Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial
Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol
Molecular Function: protein binding
Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of protein homooligomerization; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of neuron apoptosis; release of sequestered calcium ion into cytosol; determination of adult life span; response to DNA damage stimulus; negative regulation of growth
Reference #:  Q9BXH1 (UniProtKB)
Alt. Names/Synonyms: BBC3; Bcl-2-binding component 3; BCL2 binding component 3; FLJ42994; JFY-1; JFY1; p53 up-regulated modulator of apoptosis; PUMA
Gene Symbols: BBC3
Molecular weight: 20,532 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PUMA

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S10‑p
protein degradation: S10‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 4 S10-p RARQEGSsPEPVEGL
0 1 G21 VEGLARDGPRPFPLG
1 0 Y58-p PTLLPAAyLCAPTAP
1 0 S96-p RPDGPQPsLSLAEQH
1 0 S106-p LAEQHLEsPVPSAPG
1 0 Y152-p ADDLNAQyERRRQEE
0 1 S166-p EQQRHRPsPWRVLyN
1 1 Y172-p PsPWRVLyNLIMGLL
  mouse

 
S10-p RARQEGSsPEPVEGL
S21-p VEGLARDsPRPFPLG
Y58 PALLPAAYLCAPTAP
S96 RPDGPQPSLSPAQQH
S106 PAQQHLESPVPSAPE
Y152 ADDLNAQYERRRQEE
S166 EQHRHRPSPWRVMYN
Y172 PSPWRVMYNLFMGLL
  rat

 
S10 RARQEGSSPEPVEGL
S21 VEGLARDSPRPFPLG
Y58 PALLPAAYLCAPTAP
S96 RPDGPQPSLSPAQQH
S106 PAQQHLESPVPSAPE
Y152 ADDLNAQYERRRQEE
S166 EQHRHRPSPWRVMYN
Y172 PSPWRVMYNLFMGLL
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