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PUMA (mouse)

Overview PUMA Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Mitochondrial Cellular Component: mitochondrial envelope; mitochondrion Molecular Function: BH domain binding; protein binding Biological Process: caspase activation; release of cytochrome c from mitochondria; apoptosis; positive regulation of protein homooligomerization; positive regulation of apoptosis; determination of adult life span; positive regulation of neuron apoptosis; release of sequestered calcium ion into cytosol; reduction of endoplasmic reticulum calcium ion concentration; induction of apoptosis; negative regulation of cell growth; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of growth Reference #:  Q99ML1 (UniProtKB) Alt. Names/Synonyms: Bbc3; Bcl-2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; BH3-only; OTTMUSP00000025190; p53 up-regulated modulator of apoptosis; Puma; PUMA/JFY1 Gene Symbols: Bbc3 Molecular weight: 20,749 Da Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Mitochondrial Control of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PUMA 2ROC - B=130-155 (mouse) 2VOF - D/B=130-155 (mouse) 2M04 - A=1-209 (human) 4HNJ - A/B=1-209 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2ROC 2VOF  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
2	2		S10	RARQEGSSPEPVEGL
0	1		S21-p	VEGLARDsPRPFPLG
1	0		S96	RPDGPQPSLSPAQQH
1	0		S106	PAQQHLESPVPSAPE

	human
S10-p	RARQEGSsPEPVEGL
G21	VEGLARDGPRPFPLG
S96-p	RPDGPQPsLSLAEQH
S106-p	LAEQHLEsPVPSAPG

	rat
S10	RARQEGSSPEPVEGL
S21	VEGLARDSPRPFPLG
S96	RPDGPQPSLSPAQQH
S106	PAQQHLESPVPSAPE

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