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Protein Page:
PUMA (mouse)

Overview
PUMA Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial
Cellular Component: mitochondrial envelope; mitochondrion; endoplasmic reticulum; intracellular; cytosol
Molecular Function: protein binding
Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of protein homooligomerization; positive regulation of apoptosis; apoptosis; determination of adult life span; reduction of endoplasmic reticulum calcium ion concentration; release of sequestered calcium ion into cytosol; positive regulation of neuron apoptosis; negative regulation of cell growth; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to DNA damage stimulus; negative regulation of growth
Reference #:  Q99ML1 (UniProtKB)
Alt. Names/Synonyms: Bbc3; Bcl-2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; BH3-only; OTTMUSP00000025190; p53 up-regulated modulator of apoptosis; Puma; PUMA/JFY1
Gene Symbols: Bbc3
Molecular weight: 20,749 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PUMA

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
2 4 S10-p RARQEGSsPEPVEGL
0 1 S21-p VEGLARDsPRPFPLG
1 0 Y58 PALLPAAYLCAPTAP
1 0 S96 RPDGPQPSLSPAQQH
1 0 S106 PAQQHLESPVPSAPE
1 0 Y152 ADDLNAQYERRRQEE
0 1 S166 EQHRHRPSPWRVMYN
1 1 Y172 PSPWRVMYNLFMGLL
  human

 
S10-p RARQEGSsPEPVEGL
G21 VEGLARDGPRPFPLG
Y58-p PTLLPAAyLCAPTAP
S96-p RPDGPQPsLSLAEQH
S106-p LAEQHLEsPVPSAPG
Y152-p ADDLNAQyERRRQEE
S166-p EQQRHRPsPWRVLyN
Y172-p PsPWRVLyNLIMGLL
  rat

 
S10 RARQEGSSPEPVEGL
S21 VEGLARDSPRPFPLG
Y58 PALLPAAYLCAPTAP
S96 RPDGPQPSLSPAQQH
S106 PAQQHLESPVPSAPE
Y152 ADDLNAQYERRRQEE
S166 EQHRHRPSPWRVMYN
Y172 PSPWRVMYNLFMGLL
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