Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
IL28A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IL28A Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Cellular Component: extracellular space
Molecular Function: cytokine activity
Biological Process: positive regulation of immune response; mucosal immune response; JAK-STAT cascade; defense response to virus
Reference #:  Q8IZJ0 (UniProtKB)
Alt. Names/Synonyms: Cytokine Zcyto20; IFN-lambda-2; IFNL2; IL-28A; IL28A; interferon lambda 2; Interferon lambda-2; interferon-lambda 2; interleukin 28A (interferon, lambda 2); Interleukin-28A; ZCYTO20
Gene Symbols: IFNL2
Molecular weight: 22,288 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below

IL28A

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R59 QELQAFKRAKDALEE
0 1 K61 LQAFKRAKDALEESL
0 1 E66 RAKDALEESLLLKDC
  mouse

 
K53-ub KELQAFKkAkDAIEk
K55-ub LQAFKkAkDAIEkRL
K60-ub kAkDAIEkRLLEKDL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.