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Protein Page:
IL28A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
IL28A Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Cytokine
Cellular Component: extracellular space
Molecular Function: cytokine activity
Biological Process: defense response to virus
Reference #:  Q8IZJ0 (UniProtKB)
Alt. Names/Synonyms: Cytokine Zcyto20; IFN-lambda-2; IFNL2; IL-28A; IL28A; interferon lambda 2; Interferon lambda-2; interferon-lambda 2; interleukin 28A (interferon, lambda 2); Interleukin-28A; ZCYTO20
Gene Symbols: IFNL2
Molecular weight: 22,288 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below

IL28A
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 R59 QELQAFKRAKDALEE
0 1 K61 LQAFKRAKDALEESL
0 1 E66 RAKDALEESLLLKDC
  mouse

 
K53-u KELQAFKkAkDAIEk
K55-u LQAFKkAkDAIEkRL
K60-u kAkDAIEkRLLEKDL
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