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MYL4 (human)

Overview MYL4 Regulatory light chain of myosin. Does not bind calcium. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Contractile protein; Actin binding protein Cellular Component: muscle myosin complex; cytosol; A band Molecular Function: actin filament binding; actin monomer binding; structural constituent of muscle; myosin II heavy chain binding; calcium ion binding Biological Process: muscle development; positive regulation of ATPase activity; regulation of the force of heart contraction; muscle filament sliding; cardiac muscle contraction Reference #:  P12829 (UniProtKB) Alt. Names/Synonyms: ALC1; AMLC; atrial, embryonic; atrial/embryonic alkali myosin light chain; GT1; MLC1; MYL4; Myosin light chain 1, embryonic muscle/atrial isoform; Myosin light chain 4; Myosin light chain alkali GT-1 isoform; myosin, atrial/fetal muscle, light chain; myosin, light chain 4, alkali; myosin, light polypeptide 4, alkali; PRO1957 Gene Symbols: MYL4 Molecular weight: 21,565 Da Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics

Select Structure to View Below MYL4

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K10	PKKPEPKKEAAKPAP
0	1		K35	APAPEAPKEPAFDPK
0	1		K42	KEPAFDPKSVKIDFT
0	66		Y75-p	TGEMKITyGQCGDVL
0	1		K127	LQHISRNKEQGTYED
0	1		K144	EGLRVFDKEsNGtVM
0	1		K144	EGLRVFDKEsNGtVM
0	1		S146-p	LRVFDKEsNGtVMGA
0	1		T149-p	FDKEsNGtVMGAELR
0	8		K165-a	VLATLGEkMTEAEVE

	mouse
K10-a	PKKPEPKkEAAKPAA
K31-u	SAAPEPLkDSAFDPk
K38-u	kDSAFDPkSVKIDFS
Y71-p	TGEMKITyGQCGDVL
K123-u	LQHISRNkEQGTYED
K140-u	EGLRVFDkESNGTVM
K140-a	EGLRVFDkESNGTVM
S142	LRVFDkESNGTVMGA
T145	FDkESNGTVMGAELR
K161	VLATLGEKMSEAEVE

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