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Protein Page:
MYL4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MYL4 Regulatory light chain of myosin. Does not bind calcium. Note: This description may include information from UniProtKB.
Protein type: Contractile protein; Actin binding protein; Motility/polarity/chemotaxis
Cellular Component: cytosol; myosin complex; A band
Molecular Function: actin filament binding; actin monomer binding; myosin II heavy chain binding; calcium ion binding
Biological Process: positive regulation of ATPase activity; regulation of the force of heart contraction; muscle filament sliding; cardiac muscle contraction
Reference #:  P12829 (UniProtKB)
Alt. Names/Synonyms: ALC1; AMLC; atrial, embryonic; atrial/embryonic alkali myosin light chain; GT1; MLC1; MYL4; Myosin light chain 1, embryonic muscle/atrial isoform; Myosin light chain 4; Myosin light chain alkali GT-1 isoform; myosin, atrial/fetal muscle, light chain; myosin, light chain 4, alkali; myosin, light polypeptide 4, alkali; PRO1957
Gene Symbols: MYL4
Molecular weight: 21,565 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

MYL4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K10 PKKPEPKKEAAKPAP
0 1 K35 APAPEAPKEPAFDPK
0 1 K42 KEPAFDPKSVKIDFT
0 75 Y75-p TGEMKITyGQCGDVL
0 1 K127 LQHISRNKEQGTyED
0 1 Y132-p RNKEQGTyEDFVEGL
0 1 K144 EGLRVFDKEsNGtVM
0 1 K144 EGLRVFDKEsNGtVM
0 1 S146-p LRVFDKEsNGtVMGA
0 1 T149-p FDKEsNGtVMGAELR
0 8 K165-ac VLATLGEkMTEAEVE
  mouse

 
K10-ac PKKPEPKkEAAKPAA
K31-ub SAAPEPLkDSAFDPk
K38-ub kDSAFDPkSVKIDFS
Y71-p TGEMKITyGQCGDVL
K123-ub LQHISRNkEQGTYED
Y128 RNkEQGTYEDFVEGL
K140-ub EGLRVFDkESNGTVM
K140-ac EGLRVFDkESNGTVM
S142 LRVFDkESNGTVMGA
T145 FDkESNGTVMGAELR
K161 VLATLGEKMSEAEVE
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