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Protein Page:
AGO1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AGO1 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, EIF2C2/AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA. Belongs to the argonaute family. Ago subfamily. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Translation
Cellular Component: polysome; cytoplasm; cytosol; ribonucleoprotein complex
Molecular Function: endoribonuclease activity; protein binding; RNA binding
Biological Process: epidermal growth factor receptor signaling pathway; Notch signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; transcription, DNA-dependent; miRNA-mediated gene silencing, negative regulation of translation; innate immune response; gene expression
Reference #:  Q9UL18 (UniProtKB)
Alt. Names/Synonyms: AGO1; argonaute 1; Argonaute1; DKFZp686M13167; eIF-2C 1; EIF2C; eIF2C 1; EIF2C1; Eukaryotic translation initiation factor 2C 1; eukaryotic translation initiation factor 2C, 1; GERP95; Golgi Endoplasmic Reticulum protein 95 kDa; hAgo1; Protein argonaute-1; Putative RNA-binding protein Q99; Q99
Gene Symbols: AGO1
Molecular weight: 97,214 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AGO1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y336-p GQEQKHTyLPLEVCN
0 1 K438-ac GVWDMRGkQFYNGIE
0 1 T524-p IVILPGKtPVYAEVK
0 1 S621-p GSMDAHPsRYCAtVR
0 1 T626-p HPsRYCAtVRVQRPR
0 1 Y696 CIKLEKDYQPGITYI
0 1 S822-p LVDKEHDsGEGsHIS
0 2 S826-p EHDsGEGsHISGQSN
  mouse

 
Y336 GQEQKHTYLPLEVCN
K438 GVWDMRGKQFYNGIE
T524 IVILPGKTPVYAEVK
S621 GSMDAHPSRYCATVR
T626 HPSRYCATVRVQRPR
Y696-p CIKLEKDyQPGITYI
S822 LVDKEHDSGEGSHIS
S826 EHDSGEGSHISGQSN
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