Home

Ago1 (human)

Overview Ago1 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, EIF2C2/AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA. Belongs to the argonaute family. Ago subfamily. Note: This description may include information from UniProtKB. Protein type: Translation; RNA binding protein Cellular Component: polysome; cytoplasm; cytosol; ribonucleoprotein complex Molecular Function: protein binding; RNA binding Biological Process: Notch signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; miRNA-mediated gene silencing, negative regulation of translation; gene expression Reference #:  Q9UL18 (UniProtKB) Alt. Names/Synonyms: AGO1; argonaute 1; Argonaute1; DKFZp686M13167; eIF-2C 1; EIF2C; eIF2C 1; EIF2C1; Eukaryotic translation initiation factor 2C 1; eukaryotic translation initiation factor 2C, 1; GERP95; Golgi Endoplasmic Reticulum protein 95 kDa; hAgo1; Protein argonaute-1; Putative RNA-binding protein Q99; Q99 Gene Symbols: EIF2C1 Molecular weight: 97,214 Da Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Ago1 1SI2 - A=225-369 (human) 1SI3 - A=225-369 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1SI2 1SI3  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		Y336-p	GQEQKHTyLPLEVCN
0	1		K438-a	GVWDMRGkQFYNGIE
0	1		T524-p	IVILPGKtPVYAEVK
0	1		S621-p	GSMDAHPsRYCAtVR
0	1		T626-p	HPsRYCAtVRVQRPR
0	1		Y696	CIKLEKDYQPGITYI
0	1		S822-p	LVDKEHDsGEGsHIS
0	1		S826-p	EHDsGEGsHISGQSN

	mouse
Y336	GQEQKHTYLPLEVCN
K438	GVWDMRGKQFYNGIE
T524	IVILPGKTPVYAEVK
S621	GSMDAHPSRYCATVR
T626	HPSRYCATVRVQRPR
Y696-p	CIKLEKDyQPGITYI
S822	LVDKEHDSGEGSHIS
S826	EHDSGEGSHISGQSN

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.