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Protein Page:
GPNMB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GPNMB Could be a melanogenic enzyme. Belongs to the PMEL/NMB family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: integral to plasma membrane; melanosome; integral to membrane
Molecular Function: heparin binding; integrin binding
Biological Process: osteoblast differentiation; negative regulation of cell proliferation; cell adhesion; bone mineralization
Reference #:  Q14956 (UniProtKB)
Alt. Names/Synonyms: glycoprotein (transmembrane) nmb; glycoprotein NMB; glycoprotein nmb-like protein; GPNMB; HGFIN; NMB; osteoactivin; Transmembrane glycoprotein HGFIN; Transmembrane glycoprotein NMB
Gene Symbols: GPNMB
Molecular weight: 63,923 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GPNMB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 P358 PGPAGDNPLELSRIP
0 1 S499-p SPLRMANsALIsVGC
0 1 S503-p MANsALIsVGCLAIF
0 3 S542 VVRSKGLSVFLNRAK
0 1 K559 FFPGNQEKDPLLKNQ
0 1 Q566 KDPLLKNQEFKGVS_
0 1 V571 KNQEFKGVS______
  mouse

 
S362-p LMPTGYKsMELSDIS
G503 SPLRAVNGVLISIGC
S507 AVNGVLISIGCLAVL
S546-p TVKGKGLsVLLSHAK
K563-ub FFRGDQEkDPLLQDk
K570-ub kDPLLQDkPRtL___
T573-p LLQDkPRtL______
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