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Protein Page:
GPNMB (human)

Overview
GPNMB Could be a melanogenic enzyme. Belongs to the PMEL/NMB family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: integral to plasma membrane; integral to membrane; melanosome
Molecular Function: heparin binding; integrin binding
Biological Process: osteoblast differentiation; negative regulation of cell proliferation; cell adhesion; bone mineralization
Reference #:  Q14956 (UniProtKB)
Alt. Names/Synonyms: glycoprotein (transmembrane) nmb; glycoprotein NMB; glycoprotein nmb-like protein; GPNMB; HGFIN; NMB; osteoactivin; Transmembrane glycoprotein HGFIN; Transmembrane glycoprotein NMB
Gene Symbols: GPNMB
Molecular weight: 63,923 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GPNMB

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 P358 PGPAGDNPLELSRIP
0 2 S542 VVRSKGLSVFLNRAK
  mouse

 
S362-p LMPTGYKsMELSDIS
S546-p TVKGKGLsVLLSHAK
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