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PRF1 (mouse)

Overview PRF1 Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Monomer, as sobluble protein. Homooligomer. Oligomerization is required for pore formation. Repressed by contact with target cells. Belongs to the complement C6/C7/C8/C9 family. Note: This description may include information from UniProtKB. Cellular Component: extracellular space; membrane; cytoplasmic membrane-bound vesicle; plasma membrane; extracellular region; integral to membrane; cytoplasmic vesicle; endosome Molecular Function: metal ion binding; calcium ion binding; wide pore channel activity Biological Process: circadian rhythm; apoptosis; cytolysis; defense response to tumor cell; immune response to tumor cell; defense response to virus; transmembrane transport; protein homooligomerization Reference #:  P10820 (UniProtKB) Alt. Names/Synonyms: Cytolysin; Lymphocyte pore-forming protein; P1; PERF; perforin 1 (pore forming protein); Perforin-1; Pfn; Pfp; pore forming protein; Prf-1; Prf1 Gene Symbols: Prf1 Molecular weight: 62,081 Da Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PRF1 3NSJ - A=21-554 (mouse)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		T289-p	KKQHKMAtSFHQTYR

	human
A290	KKKHKMTASFHQTYR

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