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Protein Page:
METTL11A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
METTL11A Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. Belongs to the methyltransferase superfamily. NTM1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.244; EC 2.1.1.-; Methyltransferase, protein N-term; Methyltransferase
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein methyltransferase activity
Biological Process: N-terminal peptidyl-proline di-methylation; spindle organization and biogenesis; chromosome segregation; N-terminal peptidyl-alanine tri-methylation
Reference #:  Q9BV86 (UniProtKB)
Alt. Names/Synonyms: AD-003; C9orf32; ME11A; methyltransferase like 11A; Methyltransferase-like protein 11A; METTL11A; NRMT; NTMT1
Gene Symbols: NTMT1
Molecular weight: 25,387 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

METTL11A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T2-p ______MtsEVIEDE
0 2 S3-p _____MtsEVIEDEk
0 1 K10-ub sEVIEDEkQFYSKAK
0 11 K59-ub FLREGPNkTGTSCAL
0 4 Y103-p FLVQAKTyLGEEGkR
0 7 K109-ub TyLGEEGkRVRNYFC
  mouse

 
T2 ______MTSEVIEDE
S3 _____MTSEVIEDEK
K10 SEVIEDEKQFYSKAK
K59 FLREGPNKTGTSCAL
Y103 FLAKAKTYLGEEGKR
K109 TYLGEEGKRVRNYFC
  rat

 
T2 ______MTSEVIEDE
S3 _____MTSEVIEDEK
K10 SEVIEDEKQFYSKAK
K59 FLREGPNKTGTSCAL
Y103 FLAKAKTYLGEEGKR
K109 TYLGEEGKRVRNYFC
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