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Protein Page:
PIR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIR Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro). May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA. Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract. Highly expressed in a subset of melanomas. Detected at very low levels in most tissues. Expressed in all tissues, with highest level of expression in heart and liver. Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. Belongs to the pirin family. Note: This description may include information from UniProtKB.
Protein type: EC 1.13.11.24
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding; transcription cofactor activity; quercetin 2,3-dioxygenase activity
Biological Process: transcription from RNA polymerase II promoter; monocyte differentiation; regulation of transcription, DNA-dependent
Reference #:  O00625 (UniProtKB)
Alt. Names/Synonyms: PIR; Pirin; pirin (iron-binding nuclear protein)
Gene Symbols: PIR
Molecular weight: 32,113 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PIR

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T8-gl MGSSKKVtLSVLSRE
0 1 K34-ub SIGRPELkNLDPFLL
0 2 R97-m1 LQWMTAGrGILHAEM
0 1 Y131-p EKMVEPQyQELKSEE
0 1 S161-p GEALGIKsKVYTRTP
0 1 S183-p LDPGAKHsQPIPKGW
0 1 K234-ac QVENKDPkRSHFVLI
  mouse

 
T8 MASSKKVTLSVLSRE
K34 SIGRPELKNLDPFLL
R97 LQWMTAGRGILHAEM
Y131 EKMVAPQYQELKSEE
S161 GEALGIKSKVYTRTP
S183 LDQGAKHSQPIPKGW
K234 QLENKDPKRSHFVLI
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