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TNFRSF6B (human)

Overview TNFRSF6B Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted Cellular Component: extracellular space Molecular Function: protein binding; receptor activity Biological Process: apoptosis; negative regulation of apoptosis Reference #:  O95407 (UniProtKB) Alt. Names/Synonyms: DCR3; Decoy receptor 3; Decoy receptor for Fas ligand; DJ583P15.1.1; M68; TNF6B; TNFRSF6B; TR6; Tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily, member 6b, decoy Gene Symbols: TNFRSF6B Molecular weight: 32,680 Da Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TNFRSF6B 3K51 - B=30-195 (human) 3MHD - D=30-195 (human) 3MI8 - D=30-195 (human) 4J6G - D/C=30-195 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 3K51 3MHD 3MI8 4J6G  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		R284-m1	LQALRVArMPGLErS
0	1		R290-m1	ArMPGLErSVRErFL
0	1		R295-m1	LErSVRErFLPVH__

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